Rétinoblastome : résultats préliminaires du protocole national de prise en charge au CHU de Casablanca

Kettani, A. El; Aderdour, S.; Daghouj, Ghizlane; Knari, S; Zaghloul, K.; Zafad, S.; Harif, Mhamed; Benchekroun, Saïd

doi:10.1016/j.jfo.2013.05.027

Cited by 13 publications

(7 citation statements)

References 16 publications

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“…Retinoblastoma is the most frequent childhood intraocular tumor with an approximately incidence of 1/15000-20000 birth in the world [ 1 ]. In north Africa, it is the most important ocular malignancy, It is bilateral in about 25-35% of cases [ 2 ]. The recent advances for early detection and treatment like identification of genetic mutations, use of chemoreduction to minimize the size of the tumor, identification of histopathologic high risk features following enucleation and provision of adjuvant therapy to reduce the incidence of systemic metastasis, and aggressive multimodal therapy in the management of orbital retinoblastoma have contributed to improve outcomes in terms of better survival [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Though it is a rare clinical presentation in developed countries ranging from 6.3% to 7.6% [ 7 ], it is not an unusual feature in developing and under developed world [ 8 ], mortality linked to orbital retinoblastoma in these countries is still high owing to late presentations compounded by socio-economic factors with the mortality reported as high as 50-90% [ 9 , 10 ]. Previous studies in morocco had reported epidemiological and clinical characteristics of retinoblastoma [ 2 , 3 ]. The aim of our study is to present data over three years about clinical presentation, therapeutic care and outcomes of children presenting orbital retinoblastoma treated at the Mohamed VI university hospital of Marrakech, which is a referral and tertiary care center in the south of morocco, to understand various reasons for the delayed presentation and to compare our results with those reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech

Soltani¹,

Hajji²,

Hafsa³

et al. 2016

Pan Afr Med J

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Retinoblastoma is the most frequent childhood intraocular tumor. The aim of our study is to evaluate the clinical features and management of extra-ocular retinoblastoma in the Mohamed VI university hospital of Marrakech. Retrospective case series, the patient's records were reviewed for patient and tumor features, ocular management, histopathological findings, and patient survival. Over a period of three years, 35 eyes were diagnosed with retinoblastoma; 12 children (16 eyes) (46%) had extra-ocular retinoblastoma. Mean age was 27 months, 60% were males. Six cases had unilateral tumor, five bilateral and one case of trilateral retinoblastoma. There was no positive family history, proptosis was the mean mode of presentation (41,6%) followed by staphyloma (25%) orbital cellulitis (25%) and hyphema(8,3%). The median lag period was 18 months. On imaging and histopathological analysis, there was extrascleral involvement in 41.6%, involvement of orbital part of optic nerve (75%), of orbital muscles (50%) and eyelids in 16.6%. the surgical treatment included according to the degree of extension enucleation (75%) or exenteration (25%) associated to chemotherapy in all cases and one case of external beam radiation. There were 2 cases of orbital recurrence, one death and no metastases at 30 months follow-up.Orbital retinoblastoma still stands as a tall challenge requiring multi-modal and multi-disciplinary approach. Although the survival has increased over the last few years, lack of access to medical facilities, lack of education about the need for early medical attention and cultural resistance to enucleation continue to contribute to an epidemic of extra ocular disease at diagnosis in the developing world.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech

Soltani¹,

Hajji²,

Hafsa³

et al. 2016

Pan Afr Med J

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“…On the other hand, in a study carried out in Morocco in 2014, the rate of ocular conservative treatments was 85.7% and the rate survival was 81.2% at 5 years. It should also be noted that we have a fairly high loss of follow-up rate compared to other studies, including Senegal 11.9%[6] and Morocco 6.2%[17].…”

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confidence: 44%

Management of retinoblastoma in children in Madagascar

Randrianarisoa

Rakotoarisoa

Miray

et al. 2022

World Journal of Current Med and Pharm Research

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Introduction: Retinoblastoma is the most common intraocular tumor in child. The treatment is well codified combining chemotherapy, surgery, radiotherapy and conservative treatment. It involves both the visual and vital prognosis. The aim of this study was to describe epidemiological aspect of retinoblastoma and evaluate therapeutic aspects and evolution of retinoblastoma in Madagascar. Method: We report in this retrospective study 52 cases found during 5 years, from January 2010 to December 2015. We have collected information about epidemiological and clinical aspect. Delay of diagnosis, treatment done in children and evolution. Data was collected with excel software and analysis was done with Epi info 7.0 software. The quantitative variables were expressed as an average and the qualitative variables as a proportion and percentage. Result: We had collected 52 cases. The incidence was 10.4 cases per year. Mean age was 3 years, with no gender predominance. More than half or 53.8% (n=28) of children presented minor signs: including leucocoria in 25 children and strabismus in 3 children. Exophthalmos was found in 46.5% (n=24) of cases. Exophthalmia and leukocoria were associated in 6 (10%) children. The delay time before diagnosis was 11 months and 2 days. 39 pieces were sent for examination. Result of Anatomo-pathological study was: 51% (n=20) was undifferentiated retinoblastoma, 36% (n=14) differentiated retinoblastoma, 13% diffused retinoblastoma (n=5) Optic nerve was affected in 7.69% of cases (n=3). Before diagnosis, 55.8% (n=29) of our patients received non-specialized medical treatment and 44.2% (n=23) used traditional treatment. Four patients had primitive enucleation without first chemotherapy. Nine children or 18.75% didn’t have surgical treatment. Neoadjuvant chemotherapy was done in 92.3% (n = 48). 39 patients had first chemotherapy before enucleation. Only 58% of children have received adjuvant chemotherapy. The evolution was marked by 27% (n = 14) of remission, 21% (n = 11) of death and 8% (n = 4) of recurrence. Twenty-three patients (44%) were lost to follow-up. Conclusion: Diagnosis of retinoblastoma was made in advanced stage. Number of lost to follow-up were high. Treatment consist in chemotherapy and enucleation. Prognosis was worse in Madagascar. Communication with parents, medical personal must recommended to reduce number of children lost to follow-up.

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“…These data from the literature correspond to our series where the overall survival rate at five years is 85.41%. The factors that worsen the prognosis are the size of the tumor and the extra-retinal extension with the invasion of the choroid, the sclera, or the optic nerve [ 9 ]. Thirteen or 9.02% of the patients in our series died.…”

Section: Discussionmentioning

confidence: 99%

Anatomo-Clinical Aspects of Retinoblastoma: A Series of 144 Cases

Silva¹,

Kora²,

Elongo³

et al. 2022

Cureus

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Retinoblastoma (RB) is the most common intraocular primary malignancy for infants and young children. The tumor is bilateral in 40% of cases and unilateral in 60% of cases. The hereditary form is due to a germinal mutation in the RB1 tumor suppressor gene. In developed countries, patients treated for RB have excellent survival, but unfortunately in developing countries delays in diagnosis and lack of human and financial resources are responsible for deaths. We conducted a retrospective study of 144 cases of RB in order to evaluate the clinico-pathological aspect of RB for the national reference center of RB in Morocco. Our study highlighted the indispensable collaboration between the clinician and the pathologist. Besides the diagnostic confirmation, the anatomopathological study gives us information on histopronostic risk factors to guide the treatment.

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Rétinoblastome : résultats préliminaires du protocole national de prise en charge au CHU de Casablanca

Cited by 13 publications

References 16 publications

Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech

Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech

Management of retinoblastoma in children in Madagascar

Anatomo-Clinical Aspects of Retinoblastoma: A Series of 144 Cases

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