Retinoic acid-driven <i>Hox1</i> is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis

Sasakura, Yasunori; Kanda, Miyuki; Ikeda, Taku; Horie, Takeo; Kawai, Nobuyoshi; Ogura, Yosuke; Yoshida, Reiko; Hozumi, Akiko; Satoh, Nori; Fujiwara, Shigeki

doi:10.1242/dev.080234

Cited by 49 publications

(38 citation statements)

References 42 publications

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“…Further posterior, the atrial siphon primordia in turn express several TFs of the posterior placodal area in vertebrates such as Pax2/5/8 (which is, however, also expressed in the OSP), FoxI, Phox2, and Hox1 (Mazet et al, 2005;Sasakura et al, 2012;Wada, Saiga, Satoh, & Holland, 1998). Like the posterior placodal area, the atrial siphon primordia also are induced by FGF, invaginate and give rise to mechanosensory cells (Bone & Ryan, 1978;Kourakis et al, 2010;Kourakis & Smith, 2007;Mackie & Singla, 2003) (see below).…”

Section: Ectodermal Patterningmentioning

confidence: 99%

Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale

Schlosser

2015

Current Topics in Developmental Biology

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Section: Ectodermal Patterningmentioning

confidence: 99%

Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale

Schlosser

2015

Current Topics in Developmental Biology

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“…Bilateral pairs of ASMFs divide antero-posteriorly to form four ASM precursor cells (ASMPs), which then migrate towards the atrial siphon placode, divide and form a ring of eight cells (Figure 1A). These cells later continue to proliferate and produce two populations of body wall muscles: the ASM sensu stricto and the longitudinal muscles (LoM; Figure 1A; Sasakura et al, 2012; Stolfi et al, 2010). Ciona intestinalis juveniles possess two bilateral atrial siphons that fuse several days after metamorphosis (Chiba et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Collier/OLF/EBF-Dependent Transcriptional Dynamics Control Pharyngeal Muscle Specification from Primed Cardiopharyngeal Progenitors

et al. 2014

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SUMMARY In vertebrates, pluripotent pharyngeal mesoderm progenitors produce the cardiac precursors of the second heart field as well as the branchiomeric head muscles and associated stem cells. However, the mechanisms underlying the transition from multipotent progenitors to distinct muscle precursors remain obscured by the complexity of vertebrate embryos. Using Ciona intestinalis as a simple chordate model, we show that bipotent cardiopharyngeal progenitors are primed to activate both heart and pharyngeal muscle transcriptional programs, which progressively become restricted to corresponding precursors. The transcription factor COE (Collier/OLF/EBF) orchestrates the transition to pharyngeal muscle fate both by promoting an MRF-associated myogenic program in myoblasts and by maintaining an undifferentiated state in their sister cells through Notch-mediated lateral inhibition. The latter are stem cell-like muscle precursors that form most of the juvenile pharyngeal muscles. We discuss the implications of our findings for the development and evolution of the chordate cardiopharyngeal mesoderm.

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“…A TALEN pair designed to target the Hox1 locus was expressed in the endodermal tissues under the control of Titf1 regulatory sequence, which expresses downstream genes in the endoderm and a small subset of neural cells (Ristoratore et al, 1999;Sasakura et al, 2012). The endodermspecific disruption of Hox1 allowed embryos to develop to juveniles with normal atrial siphons and gill slits, both of which are lost in Hox1 mutant animals .…”

Section: Resultsmentioning

confidence: 99%

Hox-mediated endodermal identity patterns the pharyngeal muscle formation in the chordate pharynx

et al. 2017

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The chordate pharynx, possessing gill slits and the endostyle, is a complex of multiple tissues that are highly organized along the anterior-posterior (AP) axis. Although Hox genes show AP coordinated expression in the pharyngeal endoderm, tissue-specific roles of these factors for establishing the regional identities within this tissue have not been demonstrated. Here, we show that Hox1 is essential for the establishment of AP axial identity of the endostyle, a major structure of the pharyngeal endoderm, in the ascidian Ciona intestinalis. We found that knockout of Hox1 causes posterior-toanterior transformation of the endostyle identity, and that Hox1 represses Otx expression and anterior identity, and vice versa. Furthermore, alteration of the regional identity of the endostyle disrupts the formation of body wall muscles, suggesting that the endodermal axial identity is essential for coordinated pharyngeal development. Our results demonstrate an essential role of Hox genes in establishment of the AP regional identity in the pharyngeal endoderm and reveal crosstalk between endoderm and mesoderm during development of chordate pharynx.

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Retinoic acid-driven Hox1 is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis

Cited by 49 publications

References 42 publications

Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale

Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale

Collier/OLF/EBF-Dependent Transcriptional Dynamics Control Pharyngeal Muscle Specification from Primed Cardiopharyngeal Progenitors

Hox-mediated endodermal identity patterns the pharyngeal muscle formation in the chordate pharynx

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