Retinoic acid metabolism, signaling, and function in the adult testis

Hogarth, Cathryn A.

doi:10.1016/b978-0-12-417047-6.00009-0

Cited by 10 publications

(9 citation statements)

References 109 publications

(153 reference statements)

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“…Spermatogonium and spermatocyte development require RA signalling, while spermatozoa only use endogenous metabolite concentrations. [24][25][26][27][28] The requirement for retinoids in sperm development, and their ability to restore male fertility when topically administered, highlights the importance of these metabolites during spermatogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…RA is a small hydrophilic signal molecule that plays a role at the earliest stages of spermatogenesis to regulate the expression of factors involved in differentiation and proliferation, like SOX9 or DAZL. [24][25][26][27][29][30] RA participates in class switching during meiosis and maintains pluripotency and proliferation of stem cells through these essential factors.…”

Section: Discussionmentioning

confidence: 99%

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A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application

2022

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Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the online database including PubMed, Google Scholar, and Scopus for English studies published in the last eight years about this issue. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in assessing the studies we are going to investigate. Results: Studies indicated that retinoic acid plays an essential role during pluripotent stem cell migration and lineage commitment, cell differentiation, apoptosis, stem cell number regulation, and maturation arrest in spermatogenic cells. Retinoic acid can also affect related protein expression and signaling pathways at different stages of spermatogenesis. Four studies have applied retinoic acid to humans, all of them in the single-arm observational study. The results look promising but need further research with more controlled study methods, randomization, and large samples. Conclusions: This current systematic review emphasizes a novel retinoic acid mechanism that has not been well described in the literature previously on its functions during the first seven days of spermatogenesis, leading to new directions or explanations of male infertility cause and treatments as a part of reproductive health care.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application

2022

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“…This blood-germ cell interaction is protected by junctions to control the exchanged substances that are called the blood-testis barrier (BTB), or Sertoli cell barrier (ScB) (Mruk & Cheng, 2010, Mruk & Cheng, 2012. The Sertoli cell barrier protects the testes from xenobiotics by exporting them back into the blood (Hogarth, 2015). The substances that are larger than 1KDa cannot pass from the basal to the adluminal side of the seminiferous tubules due to tight junctions which are formed between the adjacent Sertoli cells (Walker and Cheng, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effect of Aging on Testis Structure, GLUT2, MTOR Expression and Testosterone Level in Spermatogenesis of The Rats

Moustafa

Hassan

2022

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Background: Male ageing has been previously associated with declining sperm parameters, disrupted hormone secretion and increased time to pregnancy. Aging is a natural ongoing process characterized by morphological and structural degeneration and like other organs. Glucose is essential for testicular function; the uptake of carbohydrate-derived glucose by cells is mediated by glucose transporters (GLUTs). MTOR is also involved in the maintenance and restructuring of the blood-testis barrier (BTB), a key event in the seminiferous epithelium cycle Aim of the work: In the present study, we aimed to investigate the relationship between aging and the expression of GLUT2 and MTOR in the testis, the quality of the spermatogenesis process as well as the testosterone level.Materials and methods: Eighteen rats were classified into the following experimental age groups, premature, mature and aged the rats were weighed and sacrificed by decapitation under a mild dose of anesthetic ether testicular tissue was existed for histological, histochemical, immunohistochemical and molecular techniques.Results: In the aged group, Hematoxylin and Eosin stain, showed a decreased number of sperms that were observed in the lumen of seminiferous tubules, weak PAS reaction in basement membranes moderate immunohistochemical reaction for GLUT2 and MTOR antibodies, also decreased level of testosterone hormone was observed.Conclusion: spermatogenesis process is affected badly by aging that was clear histologically in testicular tissue and the decreased level of testosterone hormone.

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“…La espermiogénesis y la espermiación parecen estar reguladas por la vía de señalización del AR (Hogarth, 2015). El AR derivado de células de Sertoli que actúa sobre los heterodímeros RARα/RXRβ en células de Sertoli es esencial para la espermiación, se documenta que.…”

Section: Células De Leydigunclassified

“…El AR derivado de células de Sertoli que actúa sobre los heterodímeros RARα/RXRβ en células de Sertoli es esencial para la espermiación, se documenta que. la eliminación del gen que codifica RARα, causa anormalidades tanto en la espermiogénesis como en la espermiación (Hogarth, 2015).…”

Section: Células De Leydigunclassified

Alteraciones testiculares en la diferenciación de gonocitos y sus efectos en la etapa juvenil de ratas con hipotiroidismo congénito

Zúñiga

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Retinoic acid metabolism, signaling, and function in the adult testis

Cited by 10 publications

References 109 publications

A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application

A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application

Effect of Aging on Testis Structure, GLUT2, MTOR Expression and Testosterone Level in Spermatogenesis of The Rats

Alteraciones testiculares en la diferenciación de gonocitos y sus efectos en la etapa juvenil de ratas con hipotiroidismo congénito

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