Retinoic acid reduces solvent‐induced neuropathy and promotes neural regeneration in mice

Abstract

In humans, exposure to organic solvents (OS) is frequent in work activities or as a recreational inhalant, inducing severe neuropathy (secondary to demyelization of peripheral nerves). We have previously shown that all-trans retinoic acid (ATRA) increases local content of neural growth factor (NGF), improving peripheral neuropathy of diverse origins. In this study, we evaluated the effect of ATRA on OS-induced peripheral neuropathy in experimental mice. Two simultaneous experiments were performed. The first one aimed to evaluate ATRA for the prevention of damage induced by OS, the second to test ATRA as an OS-induced neuropathy treatment. Nociceptive threshold latency and NGF concentration in serum and in peripheral nerves were determined. Morphological changes and evidence of sciatic nerve regeneration were evaluated. Mice exposed to OS developed neuropathy and axonal degeneration. ATRA diminished the effects of OS inhalation on sensorial changes and nerve morphology. Treatment with ATRA reversed sensorial and nerve morphological changes of OS-induced neuropathy, and this was associated with increased contents of NGF. Similar to previous experiences on diabetic and toxic neuropathy, ATRA reduced and partially reversed the peripheral neuropathy caused by OS exposure. These favorable effects apparently are due to local production of NGF induced by neural regeneration in response to the administration of retinoic acid.

Identifying circRNA–miRNA–mRNA Regulatory Networks in Chemotherapy-Induced Peripheral Neuropathy

“…Tretinoin (also known as retinoic acid) is a retinol (vitamin A) derivative used to treat photodamaged skin [ 68 ]. It could reduce neuropathy and promote neural regeneration [ 69 ], whereas retinoic acid signaling is essential for dendritic cell maturation and T cell immunity [ 70 ], consistent with our predictions. Although the efficacy of the putative drugs requires further validation, it may shed light on potential treatments and mechanisms for CIPN.…”

A Comparative Study between the Effect of Nerve Growth Factor and All-Trans Retinoic Acid versus their combined use on Taxol Induced Peripheral Neuropathy in Adult Male Albino Rat

“…Moreover ATRA could regulate actin polymerization in microtubules that disturbed by taxol by transcription of the neurotrophin receptor genes [49] . On the other hand, NGF induces the production of retinaldehyde dehydrogenase type 2, which synthesizes retinoic acid and stimulates its intracellular pathways [50] . This combination will be able to achieve the challenge in taxol chemotherapy as it could improve the induced neuropathy and increase the efficacy of its cytotoxicity.…”