Retinoic acid signaling in development and differentiation commitment and its regulatory topology

Wu, Di; Khan, Faheem Ahmed; Zhang, Kejia; Pandupuspitasari, Nuruliarizki Shinta; Negara, Windu; Guan, Kaifeng; Sun, Fei; Huang, Chunjie

doi:10.1016/j.cbi.2023.110773

Cited by 7 publications

(2 citation statements)

References 318 publications

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“…Conversely, in the absence of retinol, DCs lead to the induction of Th17 cells, resulting in an inflammatory response characterized by IL-17 production. Moreover, impaired migration of B and T cells to the gastrointestinal tract was found in retinol-deficient rats ( 34 ). Retinoic acid enhances the generation of Treg cells, which play a role in counteracting colitis.…”

Section: Discussionmentioning

confidence: 99%

Diet-derived circulating antioxidants and risk of inflammatory bowel disease: a Mendelian randomization study and meta-analysis

Zou,

Liang,

Zhang

et al. 2024

Front. Immunol.

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BackgroundPrevious studies have shown conflicting results regarding the impact of circulating antioxidants on the risk of inflammatory bowel disease (IBD). In this study, our intent was to investigate the causal relationship between circulating antioxidants and IBD using Mendelian randomization (MR).MethodsInstrumental variables for absolute circulating antioxidants (ascorbate, retinol, lycopene, and β-carotene) and circulating antioxidant metabolites (α-tocopherol, γ-tocopherol, ascorbate, and retinol) were screened from published studies. We obtained outcome data from two genome-wide association study (GWAS) databases, including the international inflammatory bowel disease genetics consortium (IIBDGC, 14,927 controls and 5,956 cases for Crohn’s disease (CD), 20,464 controls and 6,968 cases for ulcerative colitis (UC), and 21,770 controls and 12,882 cases for IBD) and the FinnGen study (375,445 controls and 1,665 cases for CD, 371,530 controls and 5,034 cases for UC, and 369,652 controls and 7,625 cases for IBD). MR analysis was performed in each of the two databases and those results were pooled using meta-analysis to assess the overall effect of exposure on each phenotype. In order to confirm the strength of the findings, we additionally conducted a replication analysis using the UK Biobank.ResultsIn the meta-analysis of the IIBDGC and FinnGen, we found that each unit increase in absolute circulating level of retinol was associated with a 72% reduction in the risk of UC (OR: 0.28, 95% CI: 0.10 to 0.78, P=0.015). The UC GWAS data from the UK Biobank also confirmed this causal relationship (OR: 0.99, 95% CI: 0.97 to 1.00, P=0.016). In addition, there was suggestive evidence that absolute retinol level was negatively associated with IBD (OR: 0.41, 95% CI: 0.18 to 0.92, P=0.031). No other causal relationship was found.ConclusionOur results provide strong evidence that the absolute circulating level of retinol is associated with a reduction in the risk of UC. Further MR studies with more instrumental variables on circulating antioxidants, especially absolute circulating antioxidants, are needed to confirm our results.

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Section: Discussionmentioning

confidence: 99%

Diet-derived circulating antioxidants and risk of inflammatory bowel disease: a Mendelian randomization study and meta-analysis

Zou,

Liang,

Zhang

et al. 2024

Front. Immunol.

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“…RA signaling is a known epigenetic regulator during differentiation, acting through various mechanisms, including regulation of chromatin dynamics during transcription (Urvalek and Gudas, 2014 ; Wu et al, 2024 ). RA is also involved in non-canonical post-transcriptional regulation, such as mRNA processing, including mRNA splicing (Laserna et al, 2009 ) and production of non-coding RNAs (ncRNAs) (García-Padilla et al, 2021 ).…”

Section: Development: a Brief Overview Of The Role Of Retinoidsmentioning

confidence: 99%

Non-canonical retinoid signaling in neural development, regeneration and synaptic function

Piazza,

Carlone,

Spencer

2024

Front. Mol. Neurosci.

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Canonical retinoid signaling via nuclear receptors and gene regulation is critical for the initiation of developmental processes such as cellular differentiation, patterning and neurite outgrowth, but also mediates nerve regeneration and synaptic functions in adult nervous systems. In addition to canonical transcriptional regulation, retinoids also exert rapid effects, and there are now multiple lines of evidence supporting non-canonical retinoid actions outside of the nucleus, including in dendrites and axons. Together, canonical and non-canonical retinoid signaling provide the precise temporal and spatial control necessary to achieve the fine cellular coordination required for proper nervous system function. Here, we examine and discuss the evidence supporting non-canonical actions of retinoids in neural development and regeneration as well as synaptic function, including a review of the proposed molecular mechanisms involved.

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Kidney development at a glance: metabolic regulation of renal progenitor cells

Kurtzeborn,

El-Dahr,

Pakkasjärvi

et al. 2024

Current Topics in Developmental Biology

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Retinoic acid signaling in development and differentiation commitment and its regulatory topology

Cited by 7 publications

References 318 publications

Diet-derived circulating antioxidants and risk of inflammatory bowel disease: a Mendelian randomization study and meta-analysis

Diet-derived circulating antioxidants and risk of inflammatory bowel disease: a Mendelian randomization study and meta-analysis

Non-canonical retinoid signaling in neural development, regeneration and synaptic function

Kidney development at a glance: metabolic regulation of renal progenitor cells

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