Retinoic acid syndrome: a problem of the past?

Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate

“…32 Currently, hematology oncologists are well aware of RA syndrome and know how to handle this -practically the sole, serious, adverse event of ATRA therapy. 34 Prevention of rapid 35 but is controversial because the number of patients studied was too small and no prospective randomized trial has been conducted and also because adverse effects of corticosteroids such as diabetes mellitus may occur, especially in elderly patients. Early recognition of clinical signs of this syndrome followed by prophylactic or therapeutic use of corticosteroids is necessary.…”

“…By these practices, the mortality rate from RA syndrome has currently been reduced from up to 28% in the early days of the ATRA era to less than a few percent. 17,34 Postremission consolidation chemotherapy Most multicenter study groups give two to three courses of consolidation therapy with cytotoxic drugs for patients achieving CR. This approach is justified based on the therapeutic experience in AML.…”

Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line

“…37 In this study, we administered dexamethasone to mice. The results imply novel preventive approaches to RAS, and mRNA levels revealed that the LIX and MIP-2 expressions were completely inhibited by the dexamethasone injection.…”

Retinoic acid and steroid in acute promyelocytic leukemia

“…1 Although the role of RA in the treatment of acute promyelocytic leukemia (APL) have been shown extensively, RA syndrome is a serious complication observed in some patients with APL . In order to prevent RA syndrome, administration of high-dose corticosteroids have been proven to be a very effective treatment approach.…”