Retinoid nanoparticulates: Approachable gateway for acne treatment

Lalrengpuii, Judy; Raza, Kaisar; Mishra, Awanish; Shukla, Rahul

doi:10.1016/j.hsr.2022.100042

Cited by 5 publications

(16 citation statements)

References 55 publications

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“…Post-absorption retinoids bind to different nucleic acid and cytosolic receptors at the molecular level to exert their action that initiates immune variations, inflammatory responses, and different cell programs such as cell differentiation and proliferation for epidermal thickening [27,47,74]. Cytosolic retinol binding proteins (CRBP I and II) and cytosolic retinoic acid binding proteins (CRABP I and II) are protein transporters essential to activate the receptors so that subsequent binding to nuclear receptors occurs [47].…”

Section: Mechanism Of Action Of Topical Retinoids In the Anti-aging P...mentioning

confidence: 99%

“…Cytosolic retinol binding proteins (CRBP I and II) and cytosolic retinoic acid binding proteins (CRABP I and II) are protein transporters essential to activate the receptors so that subsequent binding to nuclear receptors occurs [47]. Retinoids bind to nuclear receptors like retinoic acid receptors (RAR) and retinoid X receptors (RXR) present within the nucleus of skin cells [27,47,74]. These receptors are ligand-dependent transcription factors, wherein retinoic acid is the natural ligand for the RAR superfamily while 9-cis-retinoic acid is the natural ligand for the RXR superfamily [47].…”

Section: Mechanism Of Action Of Topical Retinoids In the Anti-aging P...mentioning

confidence: 99%

“…Post binding, RAR, and RXR form dimers [47]. Dimers formed can be homodimers (RAR/RAR) or heterodimers (RAR/RXR) [74]. These dimers bind to the suitable retinoid responsive elements (RAREs and RXREs) that induce successive gene expression which leads to cell differentiation [27,47,74].…”

Section: Mechanism Of Action Of Topical Retinoids In the Anti-aging P...mentioning

confidence: 99%

“…Dimers formed can be homodimers (RAR/RAR) or heterodimers (RAR/RXR) [74]. These dimers bind to the suitable retinoid responsive elements (RAREs and RXREs) that induce successive gene expression which leads to cell differentiation [27,47,74]. The mechanism of action of retinoids to repair photodamaged skin can be sought from both the RARs and RXRs as shown in Figure 4 [27].…”

Section: Mechanism Of Action Of Topical Retinoids In the Anti-aging P...mentioning

confidence: 99%

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Retinoids—A unique ingredient for skin rejuvenation employing novel drug delivery systems

Pradhan,

Kuchekar,

Gawade

et al. 2024

J Appl Pharm Sci

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Millions of people around the world fall within the age group of 35 and above; having fluctuating lifestyles, increased exposure to blue light, and a faster-depleting ozone layer that enhances entry of UVA and UVB rays in the skin which tends to age faster leading into collagen degradation that results in fine lines and decreased cell senescence. The goal of skin rejuvenation is to have healthy skin. Cosmeceuticals incorporating retinoids have been increasingly used over the past few years to promote collagen synthesis and rejuvenate the skin. Photo-induced and chronological aging processes are decelerated with retinoid application that endorses skin elasticity by free radical neutralization, new cell growth, and blood vessel promotion within the skin to help fight pigmentation and reduce fine lines. Retinoids are commercially available as creams and serums for topical application. Nanotechnology is used in the development of retinoids to counteract adverse reactions like skin irritation and purging to improve its stability, efficacy, and acceptability. Emerging studies on retinoids include formulating them within liposomes, solid lipid nanoparticles, nano-emulgels, and hydrogels. This review details understanding the aging process, the mechanism of action of retinoids to counterfeit aging, and the potential use of nanotechnological delivery in cosmeceuticals.

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Section: Mechanism Of Action Of Topical Retinoids In the Anti-aging P...mentioning

confidence: 99%

Section: Mechanism Of Action Of Topical Retinoids In the Anti-aging P...mentioning

confidence: 99%

Section: Mechanism Of Action Of Topical Retinoids In the Anti-aging P...mentioning

confidence: 99%

Section: Mechanism Of Action Of Topical Retinoids In the Anti-aging P...mentioning

confidence: 99%

See 2 more Smart Citations

Retinoids—A unique ingredient for skin rejuvenation employing novel drug delivery systems

Pradhan,

Kuchekar,

Gawade

et al. 2024

J Appl Pharm Sci

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show abstract

“…Proper hydration is essential for Acne is a common skin condition which can affect people of all ages. Cosmetic agents such as salicylic acid, benzoyl peroxide, and retinoids can help to manage acne by reducing inflammation, unclogging pores, and regulating sebum production (Lalrengpuii, Raza, Mishra & Shukla, 2022). However, it is essential to consult a dermatologist before using any acne treatment.…”

Section: Background Of the Studymentioning

confidence: 99%

Cosmetic Agents and Skin Health of Young Females in Taichung, Taiwan

2023

JMNPH

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The use of cosmetic products has become increasingly popular among women, encompassing a wide range of items such as moisturizers, makeup, cleansers, and other beauty-enhancing substances. Cosmetic agents are substances found in cosmetic products that are used to improve the appearance and health of the skin, hair, and nails. They may be natural or synthetic, and their functions may include moisturizing, exfoliating, cleaning, and UV protection. Cosmetic agents play crucial role in the formulation of cosmetic products. Different skin types respond differently to cosmetic agents, so it is important to patch test new products before incorporating them into a daily routine. It is essential to consult a dermatologist before using any cosmetic products. The study utilized the descriptive research design. The target population was 250 Females in Taichung, Taiwan. The study did sampling of 210 participants chosen from the target population of 250 Females in Taichung, Taiwan. Questionnaires were used to collect the data. The research concluded that cosmetic agents have become an essential part of daily skincare routines for many females worldwide. The effects of cosmetic agents on skin health among females are significant. Properly formulated cosmetic agents can provide a range of benefits to the skin, improving its appearance and health. Properly formulated cosmetic agents can offer a range of benefits to the skin, like moisturization, sun protection, anti-aging effects, acne management, hyperpigmentation reduction, and exfoliation. It was recommended that different cosmetic agents work best for different skin types and concerns. Oily skin may benefit from a lightweight, oil-free moisturizer, while dry skin may require a heavier, more emollient-based moisturizer. Females should look for products that comprise beneficial components like antioxidants, peptides, and humectants. Avoid products that contain harmful components like fragrances, alcohol, and sulfates, as these may irritate the skin and cause damage over time.

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A year in review: Highlights of health sciences review in 2022

Grach

Ekser

2022

Health Sciences Review

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Retinoid nanoparticulates: Approachable gateway for acne treatment

Cited by 5 publications

References 55 publications

Retinoids—A unique ingredient for skin rejuvenation employing novel drug delivery systems

Retinoids—A unique ingredient for skin rejuvenation employing novel drug delivery systems

Cosmetic Agents and Skin Health of Young Females in Taichung, Taiwan

A year in review: Highlights of health sciences review in 2022

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