Retinoid requirements in the reproduction of zebrafish

Alsop, Derek; Matsumoto, Jacquie; Brown, Scott; Kraak, Glen Van Der

doi:10.1016/j.ygcen.2007.11.008

Cited by 53 publications

(24 citation statements)

References 47 publications

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“…In our study, CYP26a gene transcription was significantly upregulated. The degradation of excessive RA is mainly catalyzed by CYP26, and it has been found that CYP26a transcription could be induced by RA in zebrafish (White et al, 1996;Alsop et al, 2007Alsop et al, , 2008. In our experiment, we were unable to measure RA concentrations, as RA contents are generally too low to be detected and also as a result of the small sample size.…”

Section: Discussionmentioning

confidence: 84%

“…Retinoids play a fundamental role in zebrafish reproduction, and RA is required for the spawning of eggs (Alsop et al, 2008). Moreover, exposure to PBDEs did not alter the expression of RALDH2 and CYP26a in the ovaries, which suggested that ovarian RA content was unaffected.…”

Section: Discussionmentioning

confidence: 95%

“…The procedure for retinoid extraction followed previous methods (Palace and Brown, 1994;Alsop et al, 2008). For the measurement of retinoids in females, the intestines, livers and eyes of four fish were pooled as one replicate sample.…”

Section: Retinoid Measurementmentioning

confidence: 99%

See 2 more Smart Citations

Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio)

Chen

Huang

et al. 2012

Aquatic Toxicology

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 95%

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Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio)

Chen

Huang

et al. 2012

Aquatic Toxicology

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“…In teleosts, expression of rbp4 was reported for the trout ovary (46,50,81), and the protein was located in trout eggs (68). Also, rbp1 expression was reported in zebrafish ovary (49) as well as the expression of raldh2, cyp26a, and RA receptors [raraa, rarga, rxrba, rxrbb, rxrga, (2)]. Yet, the pathways for retinoid transport and storage in fish oocytes are still not fully resolved.…”

mentioning

confidence: 99%

Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish

Levi

Ziv

Admon

et al. 2012

American Journal of Physiology-Endocrinology and Metabolism

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Levi L, Ziv T, Admon A, Levavi-Sivan B, Lubzens E. Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish. Am J Physiol Endocrinol Metab 302: E626 -E644, 2012. First published December 28, 2011; doi:10.1152/ajpendo.00310.2011Retinal is the main retinoid stored in oviparous eggs of fish, amphibians, and reptiles, reaching the oocytes in association with vitellogenins, the yolk precursor proteins. During early presegmentation stages of zebrafish embryos, retinal is metabolized to retinoic acid (RA), which regulates genes involved in cell proliferation, differentiation, and tissue function and is therefore essential for normal embryonic development. While synthesis of vitellogenin and its regulation by 17␤-estradiol (E2) were extensively investigated, pathways for retinal synthesis remain obscure. We determined the expression pattern of 46 candidate genes, aiming at identifying enzymes associated with retinal synthesis, ascertaining whether they were regulated by E2, and finding pathways that could fulfill the demand for retinoids during vitellogenesis. Genes associated with retinal synthesis were upregulated in liver (rdh10, rdh13, sdr) and surprisingly also in intestine (rdh13) and ovary (rdh1, sdr), concomitantly with higher gene expression and synthesis of vitellogenins in liver but also in extrahepatic tissues, shown here for the first time. Vitellogenin synthesis in the ovary was regulated by E 2. Gene expression studies suggest that elevated retinal synthesis in liver, intestine, and ovary also depends on cleavage of carotenoids (by Bcdo2 or Bmco1), but in the ovary it may also be contingent on higher uptake of retinol from the circulatory system (via Stra6) and retinol synthesis from retinyl esters (by Lpl). Decrease in oxidation (by Raldh2 or Raldh3) of retinal to RA and/or degradation of RA (by Cyp26a1) may also facilitate higher hepatic retinal levels. Together, these processes enable meeting the putative demands of retinal for binding to vitellogenins. Bioinformatic tools reveal multiple hormone response elements in the studied genes, suggesting complex and intricate regulation of these processes. extrahepatic vitellogenin synthesis; regulatory response elements; retinoids; carotenoids RETINAL IS THE PREDOMINANT RETINOID in eggs and oocytes of marine fish and some freshwater fish species and may constitute almost the entire pool of retinoids in these eggs. In oviparous eggs of nonmammalian vertebrates such as teleosts, amphibians, and birds, maternally derived retinal is bound via a Schiff-base linkage to vitellogenins (Vtgs) (15, 32, 62, 63, 64, 72 reviewed in 50). The retinal in fish oocytes and eggs consists of several isomers, whereas the all-trans form is the most abundant in zebrafish embryos (15,44). The use of the all-trans isomer of retinal for major retinoid storage is unique to reptiles, anamniotic vertebrates (teleosts and amphibians), and eggs of ascidian (33,34). This is in contrast to higher vertebrates (birds and mammals), where retinol is the...

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“…Therefore, we developed zebrafish Rxr-LBD reporters, an Rxrba-LBD and an Rxrbb-LBD to more closely examine the receptor-mediated mode of action. Of Rxrb, Rxra and Rxrg, only Rxrb was expressed in most zebrafish tissues, including liver tissue (Tallafuss et al, 2006;Alsop et al, 2008). However, Rxrb has two subtypes, Rxrba and Rxrbb, and Rxrba has several variants.…”

Section: Discussionmentioning

confidence: 99%

BDE-99, but not BDE-47, is a transient aryl hydrocarbon receptor agonist in zebrafish liver cells

Yang

Zhu

Chan

2016

Toxicology and Applied Pharmacology

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Retinoid requirements in the reproduction of zebrafish

Cited by 53 publications

References 47 publications

Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio)

Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio)

Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish

BDE-99, but not BDE-47, is a transient aryl hydrocarbon receptor agonist in zebrafish liver cells

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