Retinoids at the threshold: their biological significance and therapeutic potential

Pawson, Beverly A.; Ehmann, Carl W.; Itri, Loretta M.; Sherman, Michael I.

doi:10.1021/jm00353a001

Cited by 39 publications

(21 citation statements)

References 15 publications

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“…Retinoids are vitamin A metabolites with antioxidant, antikeratinizing and antiinfl ammatory properties (Nagao et al, 2001;Buajeeb et al, 1997;Pawson et al, 1982). They have been used both topically and systemically for the treatment of OLP; however, some types have been reported to be ineffective.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of purslane in the treatment of oral lichen planus

Agha‐Hosseini

Borhan-Mojabi

Monsef-Esfahani

et al. 2009

Phytotherapy Research

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This study evaluated the effectiveness of antioxidant-rich purslane in the treatment of oral lichen planus (OLP). A total of 37 biopsy-proven symptomatic OLP patients were selected for this randomized double-blind placebo-controlled trial. All subjects were divided into two groups to receive purslane (n = 20) or placebo (n = 17) for 3 months. Assessments were made at baseline, after 2 weeks and each month for 6 months, based on the visual analog scale (VAS) and clinical improvement including lesion type and size. Approximately 83% of the purslane patients showed partial to complete clinical improvement but 17% had no response. In the placebo group 17% experienced partial improvement, 73% did not respond and 10% showed worsening. According to VAS scores, a partial to complete response was observed in all purslane-treated patients, while 71%, 15% and 14% of the controls demonstrated partial response, no response and worsening of the symptoms, respectively. A significant decrease in VAS scores was seen at the end of the study period (p < 0.001). No serious side-effects occurred in either of the groups. According to our findings purslane is clinically effective in the treatment of OLP. Considering the lack of side-effects during the study period, it may be a favorable alternative treatment for OLP.

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Section: Discussionmentioning

confidence: 99%

Efficacy of purslane in the treatment of oral lichen planus

Agha‐Hosseini

Borhan-Mojabi

Monsef-Esfahani

et al. 2009

Phytotherapy Research

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“…Elevated serum triglycerides and enhanced sedimentation were found in 25 and 50% of the patients, respectivel y (Pawson et al, 1982). Ten percent of the patients treated with etretinate developed hypertriglyceridemia (Elias and Williams,I 981 ).…”

Section: Synthetic Retinoids Acute Subchronic and Chronicmentioning

confidence: 99%

“…Routine liver function tests, hematology, and urinalysis failed to reveal abnormalities (Sutton, 1983). The most common side effects observed after prolonged II treatment with oral 13-lli-RA were mucocutaneous dryness (chelitis), cutaneous desquamation, alopecia, epistaxis , and conjunctivitis (Pawson et al, 1982).…”

Section: Synthetic Retinoids Acute Subchronic and Chronicmentioning

confidence: 99%

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Structure-activity relationships of retinoids in developmental toxicology

Howard

Willhite

Dawson

et al. 1988

Toxicology and Applied Pharmacology

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“…Their role in the regulation of gene transcription confers on this class of substances a high potential for the treatment of diseases where malfunctioning of proliferation or differentiation processes occur [2]. In particular, they are widely used for the management of dermatological diseases such as acne and psoriasis [3].…”

Section: Introductionmentioning

confidence: 99%

Quantitative structure-activity relationship studies of RAR α, β, γ retinoid agonists

Douguet¹,

Thoreau²,

Grassy³

1999

Quant. Struct.-Act. Relat.

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Structure-Activity Relationships have been established for 140 synthetic retinoid agonists. Retinoids, natural and synthetic analogues of vitamin A, are activating ligands for Retinoic Acid Receptors (RARa, b and g), members of the nuclear receptor superfamily. A QSAR study provides information on the type of intermolecular and intramolecular interactions the active molecules are exposed to during the course of their interaction with the receptor. Retinoid structures were modelled both by molecular and quantum mechanics and were submitted to a preliminary conformational analysis based on molecular dynamics. Linear and non-linear multivariate analyses were performed, revealing the principal electronic and structural characteristics leading to good af®nity for each RAR subtype. Distinct structural features were found for each subtype: this is in agreement with the fact that the selectivity of the RAR subtypes results from the change of amino acids in the ligand cavity. Indeed, these amino-acids induce subtle changes in terms of steric properties and speci®c interactions, thus engendering speci®city. The predictive ability of these relationships has been validated using a large set of compounds which were not used to derive the model. The goal this of work was to detect relationships between structures and af®nity for a broad range of retinoids in order that this model could be used in a more general manner, for example to impose constraints in database searching, or for use in automatic structure generation software.

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Retinoids at the threshold: their biological significance and therapeutic potential

Cited by 39 publications

References 15 publications

Efficacy of purslane in the treatment of oral lichen planus

Efficacy of purslane in the treatment of oral lichen planus

Structure-activity relationships of retinoids in developmental toxicology

Quantitative structure-activity relationship studies of RAR α, β, γ retinoid agonists

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