Retinoids for preventing the progression of cervical intra-epithelial neoplasia

Helm, C. William; Lorenz, D.; Meyer, Nicholas; Rising, William; Wulff, Judith L

doi:10.1002/14651858.cd003296.pub3

Cited by 23 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar contradictory findings were also seen in cervical diseases and bladder cancer. One study showed that retinoids had no effect in preventing the progression of CIN ( Helm et al, 2013 ), while another study demonstrated that vitamin A intake was inversely associated with cervical cancer risk ( Zhang et al, 2012 ). High vitamin A intake was also associated with low bladder cancer risk ( Tang et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Retinoids in cancer chemoprevention and therapy: Meta-analysis of randomized controlled trials

Chen

Tao

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Retinoids, natural and synthetic derivatives of vitamin A, have many regulatory functions in human body, including regulating cellular proliferation, differentiation, apoptosis. Moreover, retinoids have been used successfully for the treatment of certain malignancies, especially acute promyelocytic leukemia (APL) in adults and neuroblastoma in children. However, retinoids have not yet been translated into effective systemic treatments for most solid cancers. Some recent studies have shown that retinoids promote tumorigenesis. Therefore, we performed this meta-analysis to systematically evaluate the efficacy of retinoids in the chemoprevention and treatment of cancers. We performed literature search of several electronic databases, including PubMed, Embase and Cochrane Library from 2000 January to 2021 November. Various outcomes were applied to investigate the potential of retinoids for prevention and treatment of cancers. The primary outcomes in this study were disease recurrence and clinical response. The secondary outcomes included overall survival (OS), cancer development, disease progression and event-free survival. We identified 39 randomized controlled trials with 15,627 patients in this study. Our results showed that lower recurrence rate and better clinical response were obtained in retinoids treated patients with cancer or premalignancy as compared with control. The differences were statistically significant (RR = 0.85, 95% CI = 0.74–0.96, p = 0.01; RR = 1.24, 95% CI = 1.03–1.49, p = 0.02, respectively). Retinoids treatment was not associated with improvement in overall survival, cancer development, disease progression or event-free survival. Subgroup analysis conducted based on cancer type showed that patients benefited from retinoids treatment in APL, renal cell carcinoma, hepatocellular carcinoma, lung cancer, Kaposi sarcoma, and complete hydatidiform mole. No significant therapeutic effect was noted in head and neck cancer, acute myeloid leukemia (AML), melanoma, breast cancer, bladder cancer, cervical intraepithelial neoplasia (CIN) or cervical carcinoma. Subgroup analysis based on tumor classification demonstrated that retinoids group obtained a lower recurrence rate and better clinical response than control group in solid cancers. In conclusion, clinical application of retinoids was associated with reduction in disease recurrence and improvement in clinical response, illustrating that retinoids play a key role in cancer prevention and therapy. Further research is needed to broaden the utility of retinoids in other types of cancers.Systematic Review Registration: PROSPERO, identifier CRD42022296706.

show abstract

Section: Discussionmentioning

confidence: 99%

Retinoids in cancer chemoprevention and therapy: Meta-analysis of randomized controlled trials

Chen

Tao

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…Imiquimod 5 % Creme ist in Deutschland zur Behandlung von äußerlichen Condylomata acuminata zugelassen. Imiquimod ist ein Toll-like-Receptor-7-Agonist, der über die Induktion von Interferon-alpha und Zytokinen eine lokale Immunmodulation erzielt [19,20]. Mitunter führt Imiquimod zu deutlichen lokalen Nebenwirkungen.…”

Section: Merkeunclassified

Management benigner und prämaligner Veränderungen der Vulva und der Zervix

Schüler-Toprak¹,

Ortmann²

2020

Frauenheilkunde up2date

View full text Add to dashboard Cite

“…Cure rates with treatment are about 90% 19 compared with spontaneous cure rates (regression) of approximately 40%. 22–24 Many women followed without treatment will have persistent or progressive disease after multiple colposcopies and biopsies and may no longer be candidates for ablation once treatment is advised. Because ablation is safe, 25 inexpensive, and can often be performed at the results visit, we believe that on average the benefits of early treatment with ablation outweigh the harms.…”

Section: Treatment Of Precancerous Lesionsmentioning

confidence: 99%

Cervical Cancer Screening

Sawaya

Smith‐McCune

2016

Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

Recent changes in cervical cancer screening and management guidelines reflect our evolving knowledge about cervical carcinogenesis. In the pursuit of precision, however, decision-making has become complicated. We provide an overview of cervical cancer screening with a focus on what clinicians can do to maximize screening benefits while minimizing screening harms. The approach relies on categorizing women at each step in the screening process by their estimated risk of high-grade precancerous lesions and cervical cancer. Current screening guidelines are designed to find a reasonable balance between benefits and harms by recommending less screening in most women. Current management guidelines are designed to assure consistent decisions regarding referral to colposcopy. After initial colposcopy, we outline three major management options based on risk assessment. For treatment, we recommend ablational procedures when appropriate because they are similarly effective, less costly, and potentially safer than excisional procedures. We advise caution in adopting new screening strategies until they demonstrate cost-effective patient-centered improvements compared with current strategies. Clinicians can maximize their effect on cervical cancer prevention by being attentive to guidelines, assuring that women have access to appropriate human papillomavirus vaccination and providing low-cost, high-quality screening and treatment.

show abstract

Retinoids for preventing the progression of cervical intra-epithelial neoplasia

Cited by 23 publications

References 43 publications

Retinoids in cancer chemoprevention and therapy: Meta-analysis of randomized controlled trials

Retinoids in cancer chemoprevention and therapy: Meta-analysis of randomized controlled trials

Management benigner und prämaligner Veränderungen der Vulva und der Zervix

Cervical Cancer Screening

Contact Info

Product

Resources

About