Retinol-encapsulated low molecular water-soluble chitosan nanoparticles

Recent advances of chitosan nanoparticles as drug carriers

“…The size of the nanoparticles was 102.6 ± 12.0 nm, their zeta potential was 1.45 ± 1.75, and the encapsulated ratio of chitosan cross-linked asON was 87.6 ± 3.5%. Kim et al 30 encapsulated retinol into chitosan nanoparticles through the electrostatic interaction between the amine group of chitosan and the hydroxyl group of retinol. Encapsulation into chitosan nanoparticles was shown to increase solubility of retinol by more than 1600-fold.…”

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

“…Some researchers as Kim and co-workers have obtained chitosan-based nanoparticles by this method using the encapsulated drug itself as a cross-linker, establishing electrostatic interactions between amine group of chitosan and hydroxyl group of the drug (Kim et al, 2006). Among negatively charged polysaccharides, alginate is one of the most used to obtain nanoparticles by ionic gelation.…”

“…Nanoparticles are reported to be useful formulation to solve the poor aqueous solubility of retinoids and are able to use it by intravenous injection. Chitosan has been used by Kim and coworkers in order to obtain retinol-encapsulated chitosan nanoparticles for application of cosmetic and pharmaceutical applications (Kim et al, 2006). Retinol-encapsulated nanoparticles were completely reconstituted into aqueous solution as same as original aqueous solution.…”

Preparation, characterization and rheological behavior of chitosan nanocapsule emulsion encapsulated tuberose fragrance

“…Chitosan, a natural plentiful biopolymer obtained by chitin deacetylation, mainly consists of the repeating unit of 2-amino-and 2-acetamido-2--deoxy-β-D-glucopyranose. Due to its unique properties such as favorable biological properties 5 , antimicrobial activity 6 , low toxicity, biodegradability 7 and proper mucoadhesive properties 8 , Chitosan has been extensively applied in various fi elds, such as biotechnology 9 , food ingredients 10 , pharmaceuticals 11 , waste water treatment 12 and cosmetics 13 . Sodium tripolyphosphate is an anionic cross-linker.…”