Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). SARS-CoV-2 has the potential to cause multiorgan failure (MOF), which is lethal. This review aims to evaluate the levels of some vitamins (vitamins C, A, D, and E) and minerals (zinc, iron, and selenium) in individuals infected with coronavirus. All studies reviewed indicate a deficiency in the minerals and vitamins mentioned above. We conclude that micronutrients play a significant role in the immune system and their deficiencies have a significant effect on the immune system. Although most antioxidants are believed to be present in diets, it has been suggested that taking more antioxidants will boost immunity. Although the immune system is constantly active, specific immunity is activated more when pathogens are present. The metabolites of vitamin A, D, and other nutrients control the expression of genes in immune cells.