Rétinopathie du prématuré : de la prévention au traitement

Daruich, Alejandra; Brémond‐Gignac, Dominique; Béhar-Cohen, Francine; Kermorvant, Elsa

doi:10.1051/medsci/2020163

Cited by 15 publications

(10 citation statements)

References 50 publications

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“…So far, only the relationship between disease development and an increase in VEGF derived from retinal cells secreted in response to neuronal hypoxia has been demonstrated. 45 Several scientific studies have shown that VEGF levels are higher in premature babies than in full-term babies. T. Kaukola showed high VEGF values in studies on the development of the nervous system of premature babies with cardiovascular disorders and placental insufficiency.…”

Section: Discussionmentioning

confidence: 99%

VEGF Expression in Umbilical Cord MSC Depends on the Patient’s Health, the Week of Pregnancy in Which the Delivery Took Place, and the Body Weight of the Newborn – Preliminary Report

Bieńko¹,

Wójcik²,

Więckowska³

et al. 2023

SCCAA

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Introduction: Cells collected from Wharton's jelly are a rich source of mesenchymal stem cells. They can be easily obtained and grown using the adhesive method. They produce many types of proteins, including VEGF. Their role is to participate in angiogenesis, vasodilation, stimulation of cells to migrate, and chemotactic activity. The aim of this study was to evaluate expression of genes from the vascular endothelial growth factor family: VEGFA, VEGFB and VEGFC in MSC and the analysis of dependence of the expression of the studied genes on clinical factors related to the course of pregnancy and childbirth, and health of mother and child. Material and Methods: The research material was an umbilical cord obtained from 40 patients hospitalized in the Department of Obstetrics and Pathology of Pregnancy of the Independent Public Clinical Hospital No.1 in Lublin. The age of the women was 21-46, all gave birth by cesarean section. Some of the patients suffered from hypertension and hypothyroidism. Material collected from patients immediately after delivery was subjected to enzymatic digestion with type I collagenase. The isolated cells were then cultured in adherent conditions, and then gene expression was assessed using qPCR and the immunophenotype of the cells was assessed cytometrically.Results: Conducted studies have shown significant differences in expression of VEGF family genes depending on clinical condition of mother and child. Significant differences in VEGF-family gene expression level in umbilical cord MSC collected from women with hypothyroidism, hypertension, time of labor and birth weight of the baby were shown. Conclusion:Probably due to hypoxia (caused, for example, by hypothyroidism or hypertension), the MSCs found in the umbilical cord may react with an increased expression of VEGF and a compensatory increase in the amount of secreted factor, the aim of which is, i.a., vasodilation and increase of blood supply to the fetus through the umbilical vessels.

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Section: Discussionmentioning

confidence: 99%

VEGF Expression in Umbilical Cord MSC Depends on the Patient’s Health, the Week of Pregnancy in Which the Delivery Took Place, and the Body Weight of the Newborn – Preliminary Report

Bieńko¹,

Wójcik²,

Więckowska³

et al. 2023

SCCAA

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“…First described in 1942 by T. L. Terry as retrolental fibroplasia [ 80 ], retinopathy of prematurity (ROP) is a multi-factorial pathology of retinal development and typically occurs in premature babies, involving the retinal vascular network [ 81 ].…”

Section: Major Retinal Diseases and Oxidative/nitrosative Stressmentioning

confidence: 99%

Oxidative Stress Implication in Retinal Diseases—A Review

et al. 2022

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Oxidative stress (OS) refers to an imbalance between free radicals (FRs), namely highly reactive molecules normally generated in our body by several pathways, and intrinsic antioxidant capacity. When FR levels overwhelm intrinsic antioxidant defenses, OS occurs, inducing a series of downstream chemical reactions. Both reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced by numerous chemical reactions that take place in tissues and organs and are then eliminated by antioxidant molecules. In particular, the scientific literature focuses more on ROS participation in the pathogenesis of diseases than on the role played by RNS. By its very nature, the eye is highly exposed to ultraviolet radiation (UVR), which is directly responsible for increased OS. In this review, we aimed to focus on the retinal damage caused by ROS/RNS and the related retinal pathologies. A deeper understanding of the role of oxidative and nitrosative stress in retinal damage is needed in order to develop targeted therapeutic interventions to slow these pathologies.

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“…However, it should be noted that the condition can be severe in some cases, leading to blindness if not properly managed. Furthermore, these children reported some complications, including near-sightedness, lazy eyes, crossed eyes, glaucomas, cataracts, and retinal detachment (32)(33)(34). Furthermore, the prognosis in cases with serious central retinopathy is usually favourable since it has been evidenced that most cases return to normal within 3-4 months.…”

Section: Outcomes and Prognosismentioning

confidence: 99%

Retinopathies: Types, Etiologies, and Outcome

Alnahdi¹,

Alghamdi²,

Alkandari³

et al. 2022

JOHS

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Retinopathy is a broad term that involves damages occurring to the retina. The disease is a serious one, being a significant risk factor for blindness. It might also refer to abnormal blood flow-induced retinal damage or retinal vascular disease. Disturbances in the retinal blood flow can remarkably lead to ischemia and damage to the retina. Moreover, the accumulation of exudates (causing macular edema) and bleeding might cover the photoreceptors on the retina, leading to visual impairment. In the present literature review, we have provided updated evidence regarding the types and causes, and outcomes of retinopathy. Accordingly, a comprehensive search was conducted on the databases, including Web of Science, Google Scholar, PubMed, Embase, and Scopus, to identify all relevant articles. Estimates show that retinopathy is highly prevalent among individuals with systemic disorders like diabetes and hypertension. Diabetic and hypertensive retinopathies are the commonest causes of retinopathy. Retinopathy of prematurity is another cause affecting neonates. However, the condition is usually self-limited with no interventions, although highly prevalent in around 40% of newborns. There are two main types of retinopathies, including non-proliferative and proliferative types. Both types can occur as complications of diabetes mellitus, indicating the need to enhance the management of this population and improve the quality of care. Hypertension and poor glycemic control can remarkably determine the outcomes of the disease, implying the need to apply proper health interventions. Neonates with severe retinopathy of prematurity might suffer from severe outcomes, including loss of vision, glaucomas, and cataracts.

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Rétinopathie du prématuré : de la prévention au traitement

Cited by 15 publications

References 50 publications

VEGF Expression in Umbilical Cord MSC Depends on the Patient’s Health, the Week of Pregnancy in Which the Delivery Took Place, and the Body Weight of the Newborn – Preliminary Report

VEGF Expression in Umbilical Cord MSC Depends on the Patient’s Health, the Week of Pregnancy in Which the Delivery Took Place, and the Body Weight of the Newborn – Preliminary Report

Oxidative Stress Implication in Retinal Diseases—A Review

Retinopathies: Types, Etiologies, and Outcome

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