Retinopathy and Nephropathy in Diabetes Mellitus: Comparison of the Effects of Two Forms of Treatment

Johnsson, S

doi:10.2337/diab.9.1.1

Cited by 97 publications

(28 citation statements)

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“…During the last three decades many clinical investigations have been undertaken in various parts of the world to determine if the incidence of microangiopathy is related to the degree of control of the diabetes [46]. With only a few exceptions [47] these studies have indicated that microvascular disease is less common in well controlled diabetics than in those in whom a less careful regimen of therapy is maintained [48][49][50][51][52]. Perhaps foremost in these clinical assessments is the ambitious longterm prospective study of Pirart and his collaborators [52] which has shown that diabetic capillary disease is closely related to the degree of glycemic control.…”

Section: Metabolic Hypothesis Of Diabetic Microangiopathymentioning

confidence: 99%

Search for a biochemical basis of diabetic microangiopathy

1976

Diabetologia

191

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Summary. Diabetic microangiopathy, particularly as seen in the renal glomerulus, is characterized by morphological and biochemical alterations of the capillary basement membrane. Observations from a number of disciplines have indicated that the microvascular disease is not a separately inherited entity but a true consequence or "complication" of insulin deficiency. An evaluation of the biochemical events which could be responsible for the basement membrane lesions of diabetes indicates that the hyperglycemia or plasma somatotropin elevation of this disease alone, or in combination, may play an important role.

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Section: Metabolic Hypothesis Of Diabetic Microangiopathymentioning

confidence: 99%

Search for a biochemical basis of diabetic microangiopathy

1976

Diabetologia

191

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“…Even early studies in the 1960's and 1970's suggested an association between poor glycaemic control and increased risk of microvascular complications [10,11]. After the introduction of HbAlc as a reliable measure of long-term blood glucose control, several studies confirmed this association [12][13][14][15][16][17].…”

Section: Epidemiological Studiesmentioning

confidence: 71%

Blood glucose control and microvascular complications ? what do we do now?

Bangstad¹,

Brinchmann‐Hansen

Dahl-J�rgensen³

et al. 1994

Diabetologia

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Conventional insulin treatment used during the latter part of this century has been unsuccessful in giving most patients with insulin-dependent diabetes mellitus (IDDM) a long normal life. During the last 10 years, however, our knowledge has improved dramatically. We concluded in 1987: "The accumulating evidence for the relationship between blood glucose control and the development and progression of diabetic microangiopathy, and the demonstration that early microangiopathy responds favourably to nearnormoglycaemia, calls for action to improve the care for diabetics. The question regarding blood glucose control is not in essence 'why', but 'how'?" [1]. This statement was based on the results from several Scandinavian trials which started 10-12 years ago [1][2][3][4][5][6][7]. Since then further evidence has strengthened the basis of the above conclusion, particularly results from the Stockholm study [8] and the Diabetes Control and Complications Trial (DCCT) [9]. In this review we will summarize the evidence of the benefits of near-normal blood glucose control on the development and progression of late diabetic complications, we will also focus on important areas of future research and how they apply in the clinical environment.

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“…22 In the treatment of diabetes the trend has been toward more liberal caloric intake in recent years. 23 In epidemiological studies the separation of total fat intake from total caloric intake and indeed from other measures of affluence is almost impossible. 24 Thus overweight is not nearly as common among Japanese diabetics as among American diabetics.…”

Section: Dietary Fat May Decrease Serum Triglyceride Concentrationmentioning

confidence: 99%

Diet, Diabetes, and Serum Lipids

Albrink

1964

Diabetes

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Retinopathy and Nephropathy in Diabetes Mellitus: Comparison of the Effects of Two Forms of Treatment

Cited by 97 publications

References 0 publications

Search for a biochemical basis of diabetic microangiopathy

Search for a biochemical basis of diabetic microangiopathy

Blood glucose control and microvascular complications ? what do we do now?

Diet, Diabetes, and Serum Lipids

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