Retinopathy of prematurity and risk factors: a prospective cohort study

Karna, Padmani; Muttineni, Jyotsna; Angell, Linda K.; Karmaus, Wilfried

doi:10.1186/1471-2431-5-18

Cited by 132 publications

(104 citation statements)

References 42 publications

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“…This was in agreement with the results of studies done by Shah et al, Karna et al, and Fortes et al [13][14][15] As regard the effect of birth weight on the occurrence of ROP, in study of Arroe and Peitersen, we found that birth weight was non-significant factor for development of ROP. 16 This was contradictory to with many studies, which reported that lower birth weight was significantly associated with development of ROP, and explained that by more susceptibility for oxygen therapy, prolonged ventilation, sepsis, and blood transfusion in very low birth weight infants.…”

Section: Risk Factorsupporting

confidence: 82%

Screening for retinopathy of prematurity in neonates

2016

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Section: Risk Factorsupporting

confidence: 82%

Screening for retinopathy of prematurity in neonates

2016

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“…2,3 The strong associations reported between neonatal diagnoses or therapies and subsequent ROP suggest that severe illness, or an unstable fluctuating hospital course in general, are associated with risk for developing severe ROP. [4][5][6][7][8][9][10][11][12][13][14] Standardized illness severity (IS) measurements are widely used to account for variations in neonatal outcomes among hospitals. 15 The Score for Neonatal Acute Physiology (SNAP score) 16 on the first day of life appears associated with development of any ROP 17 and severe ROP.…”

Section: Introductionmentioning

confidence: 99%

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

et al. 2007

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Objective: To test cumulative neonatal illness severity (IS) and IS fluctuation as predictors of progression from moderate to severe retinopathy of prematurity (ROP).Study Design: Data from research databases and medical record review were collected for infants from four neonatal intensive care unit (NICUs) admitted between 1995 and 2001 and diagnosed with prethreshold ROP. Cumulative neonatal IS measured using daily Scores for Neonatal Acute Physiology (SNAP) for the first 28 days of life, and IS fluctuation as assessed by summing changes between daily SNAP scores, were tested as predictors of progression to threshold ROP using logistic regression.Result: Infants progressing to threshold (n ¼ 79), compared to those not progressing to threshold (n ¼ 130), had significantly (P<0.05) lower gestational ages (25.2±1.1 versus 25.8±1.4 weeks), higher cumulative neonatal SNAP (255±77 versus 224±63 weeks) and had more severe hospitalizations as indicated by diagnoses and medical management. In regression analysis, gestational age, chronological age and presence of plus disease at first diagnosis of prethreshold were associated with development of threshold. After adjusting for these factors, cumulative neonatal SNAP was significantly associated with progression to threshold. However, addition of cumulative SNAP to the model only increased receiver-operating characteristic curve area from 0.77 to 0.78 (NS). Other factors, including SNAP fluctuation, were not associated with progression to threshold after adjustment using this model. Conclusion:Cumulative neonatal IS, as measured by cumulative SNAP, is an independent risk factor for progression from moderate to severe ROP. However, cumulative IS does not enhance assessment of risk for ROP progression after adjusting for simpler clinical factors.

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“…The incidence of severe ROP in our study over a two-year period was 21/108 (19.4%) premature babies who met the criteria for screening for ROP. Developing countries, which include this country, show the presence of severe ROP with higher gestational age and greater birth weight, but the incidence varies greatly (11,12). In our study, in the test group of newborns there was no severe ROP where the birth weight was >1460 g and gestation >31.4 weeks, but we had a smaller number of newborns under 1000 g. We can explain this by the lower survival rate of babies with very low birth weight in our conditions.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Oxygen Therapy on the Development of Retinopathy of Prematurity

Jojić¹,

Predojević-Samardžić²,

Mavija³

et al. 2015

Pedaiatr Today

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Objective -The aim of this study is to show the effect of oxygen therapy in premature babies on the development of severe ROP. Materials and methods -This retrospective research covered a period of two years, and included 108 premature babies, with birth weight <1500 g and gestational age <33 weeks, at the Children's Ward of the University Hospital Clinical Centre, Banja Luka. The effects of the length of oxygen therapy and episodes of hypoxia and hyperoxia on the development of severe ROP were analysed. Results -ROP was present in 64 (59.2%) newborns, of which 21 (19.4%) had severe ROP. The incidence of severe ROP is statistically higher with lower birth weight, <1150 g (p<0.01), lower gestational age <30 weeks, longer oxygen therapy and when there were frequent episodes of hyperoxia and hypoxia. By multiple logistic regression analysis, a very strong connection was established between severe ROP and exposure to episodes of hyperoxia (OR 32.73; CI 4.14-255.37), episodes of hypoxia (OR 14.08; CI 3.81-51.94), and oxygen therapy longer than 10 days (OR 15.54;. For most risk factors tested, there was a strong connection between severe ROP and birth weight <1250 g, gestational age <30 weeks, respiratory distress syndrome and perinatal asphyxia. Conclusion -Long-term oxygen therapy, prematurity and low birth weight with hypoxia are important factors in the development of severe ROP. Constant education is necessary of staff regarding the potentially harmful effects of oxygen in order to prevent both hypoxia and hyperoxia.

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Retinopathy of prematurity and risk factors: a prospective cohort study

Cited by 132 publications

References 42 publications

Screening for retinopathy of prematurity in neonates

Screening for retinopathy of prematurity in neonates

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

The Effect of Oxygen Therapy on the Development of Retinopathy of Prematurity

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