Retinopathy of prematurity: from oxygen management to molecular manipulation

Woods, Jonathan; Biswas, Susmito

doi:10.1186/s40348-023-00163-5

Cited by 7 publications

(14 citation statements)

References 78 publications

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“…Recent studies hypothesized that lower Insulin-like growth factor-1 (IGF-1) levels at birth could be related to the ROP occurrence, and infants' nutrition could alter the IGF-1 levels (19). In addition, a systematic review demonstrated a protective role for human milk intake against the ROP and its severe forms (20).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the causes of retinopathy of prematurity relapse following intravitreal bevacizumab injection

Milani,

Arasteh,

Saeedi-Maleki

et al. 2024

Preprint

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Background Retinopathy of prematurity (ROP) is a proliferative disorder of the developing retina. Intravitreal bevacizumab injection (IVB) is an emerging treatment for ROP is one of the treatments for ROP has many benefits. The present study aimed to determine and evaluate the risk factors for ROP recurrence following IVB injection. Materials and method In this retrospective study, 98 eyes of 49 infants with ROP who had received IVB injections as the primary treatment for type 1 ROP are included. Results Fifty-four eyes (55.1%) had Aggressive posterior retinopathy of prematurity (APROP), and forty-four (44.9%) had Stage III Plus ROP in Zone II. ROP recurred in 13 eyes (13.26%) of 8 infants. The mean period between IVB and the ROP recurrence was 8.08 (95% CI:5.32–10.83) weeks. The infants who had ROP recurrence had lower birth weight (P value = 0.002), lower postmenstrual age at IVB injection (P value = 0.001), lower IVB injection gap period from birth (P value = 0.044), higher oxygen therapy requirement rate after IVB injection (P value < 0.001, OR:19.0) and higher oxygen therapy duration (P value = 0.006). The ROP severity, gestational age at birth, and diet were not statistically different between the recurrence and complete regression groups. Out of 13 eyes treated with laser photocoagulation because of ROP relapse, macula dragging occurred in one eye, and all the cases met the complete regression. Conclusion Low birth weight and oxygen therapy are the most important risk factors for ROP relapse, which requires meticulous oxygen treatment guidelines for premature infants.

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Section: Discussionmentioning

confidence: 99%

Evaluating the causes of retinopathy of prematurity relapse following intravitreal bevacizumab injection

Milani,

Arasteh,

Saeedi-Maleki

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Recent studies hypothesized that lower Insulin-like growth factor-1 (IGF-1) levels at birth could be related to the ROP occurrence, and infants’ nutrition could alter the IGF-1 levels [ 21 ]. In addition, a systematic review demonstrated a protective role for human milk intake against the ROP and its severe forms [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the causes of retinopathy of prematurity relapse following intravitreal bevacizumab injection

Milani,

Arasteh,

Saeedi-Maleki

et al. 2024

BMC Ophthalmol

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Background Retinopathy of prematurity (ROP) is a proliferative disorder of the developing retina. Intravitreal bevacizumab injection (IVB) is an emerging treatment for severe forms of ROP, which does not restrict the visual field in comparison to laser therapy. The present study aimed to determine and evaluate the risk factors for ROP recurrence following IVB injection. Materials and methods In this retrospective study, 98 eyes of 49 infants with ROP who had received IVB injections as the primary treatment for type 1 ROP are included. Results Fifty-four eyes (55.1%) had aggressive retinopathy of prematurity (A-ROP), and forty-four (44.9%) had Stage III Plus ROP in Zone II. ROP recurred in 13 eyes (13.26%) of 8 infants. The mean period between IVB and the ROP recurrence was 8.08 (95% CI:5.32–10.83) weeks. The infants who had ROP recurrence had lower birth weight (P value = 0.002), lower postmenstrual age at IVB injection (P value = 0.001), lower IVB injection gap period from birth (P value = 0.044), higher oxygen therapy requirement rate after IVB injection (P value < 0.001, OR:19.0) and higher oxygen therapy duration (P value = 0.006). The ROP severity, gestational age at birth, and diet were not statistically different between the recurrence and complete regression groups. Out of 13 eyes treated with laser photocoagulation because of ROP relapse, macula dragging occurred in one eye, and all the cases met the complete regression. Conclusion Low birth weight and oxygen therapy are the most important risk factors for ROP relapse, which requires meticulous oxygen treatment guidelines for premature infants.

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“…Oxygen plays a central role in retinal vessel development 4 , 5 . In utero, ‘physiological hypoxia’ allows normal retinal angiogenesis, primarily at the retinal periphery 6 , 7 , with VEGF playing a key role 8 .…”

Section: Introductionmentioning

confidence: 99%

Ocular blood flow in preterm neonates

Silverman,

Urs,

Horowitz

et al. 2024

Sci Rep

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Retinopathy of prematurity (ROP) is a disorder affecting low birthweight, preterm neonates. In the preterm eye, the retina is not fully developed and neovascularization may occur at the margin between the developed vascular retina and undeveloped avascular retina. Without timely treatment by laser or intravitreal anti-vascular endothelial growth factor (VEGF) therapy, this can lead to tractional retinal detachment and blindness. Visualization of the retina in regular examinations by indirect ophthalmoscopy is hence the current standard of care, but the exams are stressful and interpretation of images is subjective. The upregulation of VEGF in ROP would suggest an increase in ocular blood flow. In this report, we evaluate the potential of ultrafast plane-wave Doppler ultrasound (PWU) to detect increased flow velocities in the orbital vessels supplying the eye in a gentle exam with objective findings. We imaged both eyes of 50 low-birthweight preterm neonates using 18 MHz PWU. Flow velocity in the central retinal artery (CRA) and vein (CRV), and the short posterior ciliary arteries were determined and values at each ROP Stage compared. We found significantly increased velocities in the CRA and CRV in Stage 3 ROP eyes, where intervention would be considered. We compared multivariate models for identifying Stage 3 eyes comprised solely of clinical factors, solely of Doppler parameters, and clinical plus Doppler parameters. The respective models provided areas under their respective ROC curves of 0.760, 0.812, and 0.904. PWU Doppler represents a gentle, objective means for identifying neonates at risk for ROP that could complement ophthalmoscopy.

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Retinopathy of prematurity: from oxygen management to molecular manipulation

Cited by 7 publications

References 78 publications

Evaluating the causes of retinopathy of prematurity relapse following intravitreal bevacizumab injection

Evaluating the causes of retinopathy of prematurity relapse following intravitreal bevacizumab injection

Evaluating the causes of retinopathy of prematurity relapse following intravitreal bevacizumab injection

Ocular blood flow in preterm neonates

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