Retinopathy of prematurity in Korean infants with birthweight greater than 1500 g

Abstract

Our study confirmed that treatment-requiring ROP does occur in infants with BW >1500 g. To avoid overlooking infants with vision-threatening ROP, an evaluation of the data from larger BW preterm infants is advisable so that screening guidelines in neonatal care units may be refined.

Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions

“…At 18-21 months, the surviving caffeine treated infants had significantly less severe ROP than placebo infants, with no difference in mortality [83]. Two recent meta-analyses similarly reported a reduction of ROP risk after caffeine treatment in preterm neonates [84,85]. This effect has been explored in mouse and rat models of OIR [86], which have demonstrated a caffeine-associated decrease in both avascular area and neovascularization of mouse retinas undergoing hyperoxia, supporting a preventive paradigm for caffeine.…”

Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity?

“…The results of many studies involving aforementioned risk factors were similar to this study and excluding the oxygen supplement policy the only other risk factors determined in this study which can be modified is human breast milk. [1][2][3][4][5][6][7][13][14][15][16][17][18] The effect of human breast milk on ROP development is a controversial issue in the literature. [19][20][21][22][23][24][25] As far as we know, studies about the pathophysiological relationship between ROP and human breast milk are limited.…”

“…The results are similar to other developing countries. 2,5,6,16,17 Although approved guidelines for the diagnosis and treatment of ROP were used in our study, these guidelines did not include babies born at the 33rd-34th gestational weeks who needed laser treatment in our study. The National Neonatology and Ophthalmology Clinics of our country released a guideline for ROP screening and treatment in 2016.…”

“…Although epidemics are not seen due to the tight control of oxygen treatment at intensive care units, ROP incidence increases by the rising amount of surviving premature infants. [1][2][3][4][5][6][7] ROP related ocular morbidities like refractive errors, strabismus, amblyopia, glaucoma, cataract, macular dragging, retinal breaks and detachment also have a tendency to increase. [8][9][10][11][12] In an attempt to prevent ROP, known and possible risk factors are worth investigating.…”

“…Frequent blood transfusions, severe infections, intracranial hemorrhages, bronchopulmonary diseases and artificial ventilation are the other well-known important risk factors. [1][2][3][4][5][6][7][13][14][15][16][17][18] These risk factors are closely related with the natural course of the disease. For example; immaturity of bone marrow, lymphoid tissue and liver is responsible from infections, hemorrhages and increased need of blood transfusion.. Immature bronchopulmonary tissue causes the prolonged need of artificial ventilation.…”