Retinopathy of prematurity: Incidence, prevalence, risk factors, and outcomes at a tertiary care center in Telangana

Le, Crystal; Basani, Laxman; Zurakowski, David; Ayyala, Ramesh S.; Agraharam, Satish Gooty

doi:10.4103/2320-3897.190785

Cited by 20 publications

(14 citation statements)

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“…On the other hand, Le C. found that other significant postnatal risk factors observed were premature infant apnea, patent ductus arteriosus and transient tachypnea of the newborn. 27 Interestingly, in this study, this last variable behaved as a protective factor for ROP (OR = 0.18 and p < 0.01). Necrotizing enterocolitis did not represent a significant risk factor for the onset of retinopathy, although several studies consider it as a risk factor for ROP.…”

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confidence: 45%

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Carranza-Mendizabal¹,

Diaz-Manrique²,

Mamani

et al. 2021

OPTH

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The purpose of this research is to determine retinopathy of prematurity (ROP) prevalence and possible risk factors associated with ROP development in newborns admitted to a neonatal unit of a Peruvian National Reference Hospital. Patients and Methods: This retrospective study included 216 preterm infants. The data were collected between January 2016 and December 2018. All infants were examined according to Peruvian guidelines for screening and treatment of ROP. The association of clinical risk factors and the development of ROP was analyzed and predictive factors were determined. Results:The study subjects were 216 preterm infants of which 72 had some stage of ROP (32 stage 1; 23 stage 2 and 17 stage 3) and 144 preterm infants without ROP. The incidence of ROP in preterm infants less than 32 weeks was 60.9%, while for those weighing less than 1500 g it was 71.6%. The factors associated with ROP were gestational age below 32 weeks, birth weight below 1500 grams, neonatal sepsis, oxygen therapy, mechanical ventilation, hyaline membrane disease, bronchopulmonary dysplasia, persistence of ductus arteriosus and intraventricular hemorrhage. Exclusive breastfeeding was found to play a protective role against ROP. Binary logistic regression analysis found that only gestational age below 32 weeks (OR, 2.637; 95% CI, 1.04-6.69), weight below 1500 grams (OR, 4.377; 95% CI, 1.75-10.92), neonatal sepsis (OR, 6.517; 95% CI, 2.81-15.14), vaginal delivery (OR, 3.748; 95% CI: 1.54-9.14), and the presence of hyaline membrane disease (OR, 3.58; 95% CI,) are predictors of ROP. Conclusion:The incidence of ROP among very low birth weight infants was 71.6%. Infants with weight below 1500 grams, neonatal sepsis, presence of hyaline membrane disease whose mother had vaginal delivery are at risk for the development of ROP. Thus, preventing premature births and encouraging exclusive breastfeeding are two main ways to prevent ROP.

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confidence: 45%

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Carranza-Mendizabal¹,

Diaz-Manrique²,

Mamani

et al. 2021

OPTH

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“…Our finding was similar to a study done by Crystal Le in which ROP was most commonly seen in Zone III (68%) and Zone II was the second most common (26%). 16 In a study done by Anudeep et al, 30% had stage 1, 37% had stage 2, and 33% had stage 3. 15 Mean birth weight of babies in the study group was 1.36 ± 0.12 kgs.…”

Section: Discussionmentioning

confidence: 94%

Prevalence and risk factors of retinopathy of prematurity inWestern Maharashtra

Kaul¹,

Magdum²,

Mohan³

et al. 2021

IJCEO

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Background: ROP is a disease of the developing immature blood vessels in the retina of premature new born by toxicity of oxygen. With the recent advances in neonatal care there has been improvement in rates of survival in premature infants. Factors playing a role in ROP are low gestational age, low birth weight and increased oxygen supplementation after birth. Aims: To study the prevalence of retinopathy of prematurity and to determine its risk factors. Materials and Methods: A prospective study was conducted in a tertiary centre from September 2018 to August 2020. 60 babies were screened with birth weight less than 1500 gms and gestational age less than 32 weeks. History was taken from parents and fundus examination was done. The grading of stages and zones was done. Data was entered in Excel and tests of statistical significance were used. Results: The prevalence of ROP was 28%. ROP was seen in zone III in 70% and 47% had stage 2 ROP. Only 7% mothers had completed less than 28 weeks of gestation. The mean birth weight was 1.36 kgs. 71% of the ROP positive babies were delivered by normal vaginal delivery. 100% babies diagnosed with ROP had been subjected to oxygen supplementation. 47% babies developed sepsis whereas 76% babies had history of RDS. Conclusion: ROP is a preventable cause of blindness in childhood. Early screening by an ophthalmologist is important to prevent this. The burden of ROP is bound to rise due to increased advances in the field of neonatology if screening protocols are not implemented stringently.

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“…Out [2] in which ROP was most commonly seen in zone III (68%), followed by zone II (26%), and only one case in zone I; Hungi et al [17] showing ROP most commonly in zone III (52.7%), followed by zone II (31.9%) and then zone I (15.4%); and study by Anudeep K et al [5] in which 29.1% had stage 1 ROP, 37.5% had stage 2, and 33.3% had stage 3 of the 24 babies who developed ROP in their study of 65 subjects. The chances of interobserver differences that might exist can be eliminated by developing a computer-based imaging technique.…”

Section: Discussionmentioning

confidence: 99%

A Study of the Demographic Profile, Screening, and Management of Patients Visiting a Retinopathy of Prematurity Clinic

Mushtaq,

Agrawal,

Bhavsar

et al. 2024

Cureus

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Background and objectiveRetinopathy of prematurity (ROP) is a retinal vasoproliferative disease affecting premature infants. Despite improvements in neonatal care and management, ROP still remains a major cause of childhood blindness worldwide. Studying the demographic profile and screening is essential to develop predictive models, to gain insights into the cause of retinal vascular diseases and diseases of prematurity, and to determine the future management and research in ROP.The objective of the present study was to estimate the incidence of ROP, to identify the risk factors that predispose to ROP, and to assess the outcome of these cases. Hence, this study was conducted in a tertiary care hospital in Maharashtra. MethodA prospective, observational study was conducted from 10 August 2022 to 10 October 2022. Infants with gestational ages < 34 weeks, birth weights < 2000 g, infants who received supplemental oxygen therapy, or patients who required NICU stay were screened for ROP. Demographic details were recorded to assess the risk factors and treatment was given according to the severity of ROP grade. ResultA total of 160 eyes of 80 infants were screened and analysed. The overall incidence of "any ROP" was 19 patients (38 eyes), i.e., 24%. Out of 80 patients, six were of 28 weeks gestational age, of whom four (67%) were positive for ROP. The mean birth weight of infants with ROP was 1331.58 ± 238.532 g (p < 0.0001). ROP stage 1 was seen in five patients (26.32%), stage 2 in 10 patients (52.63%), and stage 3 in four patients (21.0%), with no subjects in stages 4 & 5. Out of 19 patients, six (32%) had type 1 ROP, and 13 (68%) had type 2 ROP. Out of 19 cases, 13 (68%) received follow-up care based on the severity of their disease, and six (32%) were treated with panretinal photocoagulation (PRP) laser. ConclusionIncidence of any ROP was 24%. Prematurity, low birth weight, and oxygen therapy remain the most significant risk factors associated with the development of ROP. Early referral, diagnosis, and timely intervention will play a monumental role in improving the prognosis of this potentially blinding disease.

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Retinopathy of prematurity: Incidence, prevalence, risk factors, and outcomes at a tertiary care center in Telangana

Cited by 20 publications

References 0 publications

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Prevalence and risk factors of retinopathy of prematurity inWestern Maharashtra

A Study of the Demographic Profile, Screening, and Management of Patients Visiting a Retinopathy of Prematurity Clinic

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