RETRACTED: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

Huang, Chaolin; Huang, Liying; Wang, Yeming; Li, Xia; Ren, Lili; Gu, Xiaoqing; Kang, Liang; Guo, Li; Liu, Min; Zhou, Xing; Luo, Jianfeng; Huang, Zhenghui; Tu, Shengjin; Zhao, Yue; Chen, Li; Xu, Decui; Li, Yanping; Li, Caihong; Lü, Peng; Li, Yong Mei; Xie, Weixin; Cui, Dan; Shang, Lianhan; Fan, Guohui; Xu, Jiuyang; Wang, Geng; Wang, Ying; Zhong, Jingchuan; Wang, Chen; Wang, Jianwei; Zhang, Dingyu; Cao, Bin

doi:10.1016/s0140-6736(20)32656-8

Cited by 3,948 publications

(5,286 citation statements)

References 38 publications

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“…At the beginning of the vaccine era, it is mandatory to better understand the immune response to SARS-CoV-2 infection. A study by Huang et al on 94 patients showed the durability of anti-S IgG without reduction over 6 months of follow-up 6 . Another cohort of 121 patients, tested with Mount-Sinai Anti-S IgG ELISA by Wajnberg et al, presented similar rates of persistence overtime (approximately 5 months) despite a significant reduction of antibodies titer 7 .…”

Section: Letter To the Editormentioning

confidence: 99%

Is COVID-19 severity associated with anti-spike antibody duration? Data from the ARCOVID prospective observational study

Borgonovo

Passerini

Piscaglia

et al. 2021

Journal of Infection

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Section: Letter To the Editormentioning

confidence: 99%

Is COVID-19 severity associated with anti-spike antibody duration? Data from the ARCOVID prospective observational study

Borgonovo

Passerini

Piscaglia

et al. 2021

Journal of Infection

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“…Symptomatic COVID-19 is typically characterized by symptoms ranging from mild to acute respiratory distress which is associated with cytokine storm (Chen and Li, 2020; Verity et al, 2020). Moreover, extra-pulmonary symptoms ranging from CVC, inflammation, coagulopathies, multiple organ damage and neurological disorders that are also recognized as long term consequences of Covid19 or Long Covid have been described in patients with mild to severe covid-19 (Chen and Li, 2020; Cortinovis et al, 2021; Huang et al, 2021; Lamers et al, 2020; Mao et al, 2020; Neurath, 2020; Nishiga et al, 2020; Y. Wu et al, 2020; Xiao et al, 2020; Xydakis et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

Rizvi

Dalal

Sadhu

et al. 2021

Preprint

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SummarySevere acute respiratory syndrome coronavirus (SARS-CoV)-2 infection in golden Syrian hamster (GSH) causes lungs pathology and resembles to human corona virus disease (Covid-19). Extra-pulmonary pathologies and immunological parameters of SARS-CoV-2 infection remained undefined in GSH. Using in silico modelling, we identified the similarities between human and hamster angiotensin-converting enzyme-2 (ACE-2), neuropilin-1 (NRP-1) that bind to receptor-binding domain (RBD) and S1 fragment of spike protein of SARS-CoV-2. SARS-CoV-2 infection led to lung pathologies, and cardiovascular complications (CVC) marked by interstitial coronary fibrosis and acute inflammatory response. Serum lipidomic and metabolomic profile of SARS-CoV-2-infected GSH revealed changes in serum triglycerides (TG) and low-density lipoprotein (LDL), and alterations in metabolites that correlated with Covid19. Together, we propose GSH as an animal model to study SARS-CoV-2 infection and its therapy associated with pulmonary and extra-pulmonary pathologies.Abstract Figure

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“…We expect focused clinical analysis, above all the identification of the location and cellular source of IL-10 production, combined with the use of recombinant viruses in animal models that replicate the clinical phenotype of COVID-19 to reveal the underlying viral trigger and IL-10 dependent pathways. In these studies, the focus should not be limited to acute infection but furthermore consider convalescence, the emerging sequelae of COVID-19 (140), and the impact of vaccination. In conclusion, identifying the viral trigger of IL-10 release (viral genotype) and the cellular source and downstream pathways of IL-10 (endotype) in SARS-CoV-2 infection will reveal whether increased blood levels of this cytokine are a bystander or driver of disease in the different phases of COVID-19 (clinical phenotype).…”

Section: Resultsmentioning

confidence: 99%

Lung Protection vs. Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19

et al. 2021

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The pathological processes by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that make the virus a major threat to global health are insufficiently understood. Inefficient viral clearance at any stage is a hallmark of coronavirus disease 2019 (COVID-19). Disease severity is associated with increases in peripheral blood cytokines among which interleukin 10 (IL-10) increases particularly early and independent of patient age, which is not seen in active SARS-CoV infection. Here, we consider the known multi-faceted immune regulatory role of IL-10, both in protecting the lung from injury and in defense against infections, as well as its potential cellular source. While the absence of an IL-10 response in SARS is thought to contribute to early deterioration, we suspect IL-10 to protect the lung from early immune-mediated damage and to interfere with viral clearance in COVID-19. This may further both viral spread and poor outcome in many high-risk patients. Identifying the features of the viral genotype, which specifically underlie the different IL-10 dynamics as an etiological endotype and the different viral load kinetics and outcomes as clinical phenotype, may unveil a new immune evasive strategy of SARS-CoV-2.

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RETRACTED: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

Cited by 3,948 publications

References 38 publications

Is COVID-19 severity associated with anti-spike antibody duration? Data from the ARCOVID prospective observational study

Is COVID-19 severity associated with anti-spike antibody duration? Data from the ARCOVID prospective observational study

Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

Lung Protection vs. Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19

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