Retracted: A new porous Co(II)‐coordination polymer for the chemical fixation of CO₂ and treatment effect against tuberculosis by reducing the pckA expression in Mycobacterium tuberculosis

Abstract

Using the mixed-ligand method, a novel coordination polymer containing Co(II) of [Co(ditb)(tdc)] n Á5nH 2 O (1) was prepared by reacting rigid 2,5-thiophenedicarboxylic acid with flexible 1,4-di(1H-1,2,4-triazol-1-yl)butane using the slow evaporation method. Active samples of 1 (1a for short) showed good stability and the ability to capture CO 2. It can be used as a potential heterogeneous catalyst for chemical immobilization of epoxide and CO 2 to form cyclic carbonates. In addition, catalyst 1a retained its original structure after four times of reuse. Its biological properties were assessed against Mycobacterium tuberculosis (M.TB) both in vivo and in vitro. First, the bactericidal ability of the compound against M.TB was measured by a sterilization curve. Then, the expression of pckA gene related to M.TB survival was detected using reverse transcription-polymerase chain reaction. For the in vivo study, the colony-forming unit determination was performed for evaluating the antibacterial effect of the compound, and the enzyme-linked immunosorbent assay was used for the inflammatory cytokine measurement in vivo. Through molecular docking simulations, all three types of polar atoms on the complex were confirmed to have chances of interacting with the protein.

Progress in Treatment and Diagnostics of Infectious Disease with Polymers

“…Various experimental techniques revealed that this compound can kill M.tb efficiently by reducing pckA gene expression. 51 Gonzalez et al developed an intranasal vaccine for M.tb using another capsule with chitosan or polyarginine (shell) and an oily core. A toll like receptor-7 (TLR-7) imiquimod was encapsulated in the core and tested in vitro and in vivo.…”

“…The coordination polymer [Co­(ditb)­tdc] n .5 n H 2 O containing Co­(II) was prepared by mixed ligand method and its biological properties were examined in vitro and in vivo . Various experimental techniques revealed that this compound can kill M.tb efficiently by reducing pckA gene expression …”