RETRACTED: A water-stable Zn(II)-based metal-organic framework for selective detection of Fe3+ ion and treatment effect on children asthma by reducing apoptosis of eosinophil

Wang, Wenjie; Ge, Ang; Zhu, Huiping; Yang, Peipei

doi:10.1016/j.ica.2020.119526

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…The most common lung diseases include asthma, chronic obstructive pulmonary disease (COPD), fibrosis, acute lung injury (ALI), and many other breathing problems. Asthma often causes chest tightness, coughing, recurrent wheezing, and breath shortness [218]. Hydrogen sulfide (H 2 S) is regarded as an early detection biomarker for asthma, as its levels in the lung would be substantially decreased in asthma patients.…”

Section: Lung Diseasesmentioning

confidence: 99%

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Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

2022

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Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.

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Section: Lung Diseasesmentioning

confidence: 99%

“…Eosinophil infiltration significantly affects the inflammatory response of asthma. Wang et al [218] investigated a fluorescent Zn (II)-based MOF for the treatment of childhood asthma. The MOF induced eosinophils apoptosis and reduced the level of bcl-2 gene.…”

Section: Lung Diseasesmentioning

confidence: 99%