Retracted: Adsorption Features of Flavonoids on Macroporous Adsorption Resins Functionalized with Ionic Liquids

Lou, Song; Di, Duolong

doi:10.1002/cphc.201500333

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References 45 publications

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“…As powerful separating agents, MARs have numerous applications in various fields, such as chromatographic analysis, treatment, medical, wastewater disposal, and especially in the isolation and purification of active ingredients from different herbal extracts in traditional Chinese medicine [ 17 , 18 , 19 , 20 ]. Our group has been engaged in the application research of MAR for a long time [ 21 , 22 , 23 , 24 , 25 ]. We evaluated the adsorption properties of twenty-four kinds of MARs with lycopene oleoresin and screened out the best LX-68 resin from the dynamic adsorption/desorption experiments through a column packed with LX-68 resin; the best separation conditions were obtained, and the lycopene content in lycopene oleoresin increased 30.4-fold from 0.21% to 6.38%, with a recovery yield of 66.9% [ 26 ].…”

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Preparative Separation of Flavonoids from Goji Berries by Mixed-Mode Macroporous Adsorption Resins and Effect on Aβ-Expressing and Anti-Aging Genes

Liu

Meng

et al. 2020

Molecules

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Flavonoids are the main constituents of Goji berries and have good biological and pharmacological activities. The mixed-mode macroporous adsorption resins (MARs) for purification of flavonoids from Goji berries through computer-assisted calculation of the molecular size of flavonoids and the precise matching of MAR physical and chemical properties was firstly developed in the present study. Ten varieties of MARs with suitable molecular dimensions and polarities were used for investigating the adsorption/desorption behaviors of the flavonoids. Both AUKJ-1 and BWKX-1 showed higher separation efficiency than other MARs and then were mixed in different ratios to constitute a mixed-mode macroporous adsorption resin to obtain the optimal adsorption phase. Under optimal conditions, total flavonoid content of purified flavonoid (p-FLA) extract increased from 0.97% to 36.88% after one purification. The p-FLA extract from Goji berries significantly improved the expression of six genes with anti-aging effects and played an important role in aging-related Alzheimer’s disease by down-regulating Aβ expression.

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