The purpose of this research was to examine the utilization of artificial intelligence (AI) in organization development (OD) through a comprehensive review of existing literature. We also propose potential avenues for future research on AI in OD. We conducted a systematic literature review of 68 studies on AI in OD based on Cummings and Worley’s four OD categories (i.e., human process, human resource, strategic change, and technostructural interventions). We first summarized and analyzed key information about how AI is implemented in OD contexts, and then examined the underlying theories or theoretical frameworks utilized in OD studies focusing on AI. We examined the application of AI in OD, potential ethical concerns, and recommendations for future research and practice using AI in OD. The paper concludes with discussion and implications for research and practice.