2016
DOI: 10.1177/1534735416635275
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RETRACTED: Apoptotic Effects of Rotundic Acid on Human Esophagus and Lung Cancer Cells

Abstract: Rotundic acid (RA) is a pentacyclic triterpenic acid. Apoptotic effects of RA at 4, 8, or 16 µM in OE33 and A549 cell lines, an esophageal squamous cancer cell line and a non-small-cell lung cancer cell line, were examined. RA at 4 to 16 µM inhibited the survival of both cell lines. RA at 8 and 16 µM decreased Bcl-2 expression and at 4 to 16 µM upregulated Bax and cleaved caspase-3 expression. RA treatments decreased the ratio of Bcl-2/Bax in those cells. RA at 4 to 16 µM lowered Na-K-ATPase activity and reduc… Show more

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Cited by 2 publications
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