RETRACTED: Arabinogalactan derived from Larix gmelinii (Rupr.) Kuzen. Alleviates cisplatin-induced acute intestinal injury in vitro and in vivo through IRE1α/ JNK axis mediated apoptotic signaling pathways

Arabinogalactan Alleviates Lipopolysaccharide-Induced Intestinal Epithelial Barrier Damage through Adenosine Monophosphate-Activated Protein Kinase/Silent Information Regulator 1/Nuclear Factor Kappa-B Signaling Pathways in Caco-2 Cells

“…Xiong et al [29] found that LDH leakage in an LPS-treated group was conspicuously higher than that in the control group. Furthermore, AG could reduce the increase in LDH leakage in cisplatin-induced intestinal injury and thus increase cell viability [26]. Consistent with the results of previous studies, our study showed that Caco-2 cells treated with LPS showed an increase in LDH leakage, while co-treatment with AG attenuated this trend (Figure 1D).…”

“…AG possesses immuno-enhancing [22], anti-cancer [23], anti-inflammatory [24], and antioxidant activities [25]. In addition, AG has the ability to alleviate cisplatin-stimulated intestinal injury [26]; however, the mechanism of AG's effect on IEB function is still not fully understood.…”

New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets

“…1 ), thereby contributing to pro-apoptotic signaling and an inflammatory response to ER stress ( Hetz et al., 2020 ; Hooper et al., 2019 ). Studies have revealed that genetic ablation of Ire1α in intestinal epithelial cells (IECs) leads to spontaneous colitis, loss of goblet cells, and failure of the intestinal epithelial barrier function in mice ( Zhang et al., 2015 , 2022a ). Mice with IRE1α deficiency are more susceptible to the development of colitis caused by chemicals ( Zhang et al., 2022a ).…”

“…Studies have revealed that genetic ablation of Ire1α in intestinal epithelial cells (IECs) leads to spontaneous colitis, loss of goblet cells, and failure of the intestinal epithelial barrier function in mice ( Zhang et al., 2015 , 2022a ). Mice with IRE1α deficiency are more susceptible to the development of colitis caused by chemicals ( Zhang et al., 2022a ). The lack of XBP1, the master regulator of the UPR, leads to unresolved ER stress-mediated spontaneous enteritis in mice ( Foerster et al., 2022 ; Kaser et al., 2008 ), characterized by the loss of Paneth cells, reduced goblet cells, and increased susceptibility to experimental colitis ( Adolph et al., 2013 ; Foerster et al., 2022 ).…”