RETRACTED ARTICLE: A compact photometer based on metal-waveguide-capillary: application to detecting glucose of nanomolar concentration

Bai, Min; Huang, Hui; Hao, Jian; Ji, Zhang; Wu, Haibo

doi:10.1038/srep10476

Cited by 13 publications

(6 citation statements)

References 43 publications

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“…The optical path length of MWC can be greatly augmented, because light can be confined inside the capillary and refracted repeatedly. For the photometer with a 7 cm-long capillary, the detection limit can be improved 3000-fold compared with that of commercial spectrophotometer with 1 cm cuvette, as we previously reported [10].…”

Section: Introductionmentioning

confidence: 56%

Highly sensitive detection of thrombin using metal-waveguide-capillary based photometer and gold nanorods probe

Zhang

Huang

et al. 2017

Sensors and Actuators B: Chemical

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This work described a sensitive thrombin analysis method employing metal-waveguide-capillary (MWC) photometry with a sandwich aptamergold nanorods (GNRs) as a signal transporting probe. The sandwich aptasensor consisted of a pair of thrombin-binding aptamers: one 29-mer aptamer modified with magnetic beads as capture aptamers; and one 15-mer aptamer binding with GNRs as report aptamers. Through the measurement of GNRs from the sandwich complex, the MWC photometry enabled to detect thrombin with a linear range from 0.068 nM to 1.09 nM, and with a detection limit as low as 0.02 nM. The detection limit was improved 68-fold vs.

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Section: Introductionmentioning

confidence: 56%

Highly sensitive detection of thrombin using metal-waveguide-capillary based photometer and gold nanorods probe

Zhang

Huang

et al. 2017

Sensors and Actuators B: Chemical

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“…66 An optical technique that is promising -although still in the early stages -is a metal waveguide capillary (MWC) compact photometer for measuring glucose in nanomolar concentrations. 67 This detection method uses absorption and scattering to detect glucose. Usually such setups are quite large, which isn't practical for patient glucometers.…”

Section: Enzymatic Glucose Sensorsmentioning

confidence: 99%

Challenges and perspectives in continuous glucose monitoring

2018

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Diabetes is a global epidemic that threatens the health and well-being of hundreds of millions of people. The first step in patient treatment is to monitor glucose levels. Currently this is most commonly done using enzymatic strips. This approach suffers from several limitations, namely it requires a blood sample and is therefore invasive, the quality and the stability of the enzymatic strips vary widely, and the patient is burdened by performing the measurement themselves. This results in dangerous fluctuations in glucose levels often going undetected. There is currently intense research towards new approaches in glucose detection that would enable non-invasive continuous glucose monitoring (CGM). In this review, we explore the state-of-the-art in glucose detection technologies. In particular, we focus on the physical mechanisms behind different approaches, and how these influence and determine the accuracy and reliability of glucose detection. We begin by reviewing the basic physical and chemical properties of the glucose molecule. Although these play a central role in detection, especially the anomeric ratio, they are surprisingly often overlooked in the literature. We then review state-of-the art and emerging detection methods. Finally, we survey the current market for glucometers. Recent results show that past challenges in glucose detection are now being overcome, thereby enabling the development of smart wearable devices for non-invasive continuous glucose monitoring. These new directions in glucose detection have enormous potential to improve the quality of life of millions of diabetics, as well as offer insight into the development, treatment and even prevention of the disease.

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“…The group of N.Y. Kim et al created a reusable radiofrequency resonator based integrated passive device biosensor chip for the detection of Glucose in aqueous solutions, and the minimum level of detection was 0.033 µM 1 . Another group designed a low-cost photometer based on metal-waveguide-capillary (MWC) for ultrasensitive detection of Glucose as low as 5.12 nanomolar, in this case, light passed through the photometers and authors detected the optical signals, that in turn, produced a voltage and the amplitude of the voltage signals is related with the concentration of Glucose in the solution 10 . Other techniques have been developed in order to detect Glucose such as: the printing of patterns using gold nanoparticles to create a Glucose sensor 11 , simple inspection of color change in solutions of gold nanoparticles 12 , photoelectrical detection using TiO 2 nanowires with surface-functionalized Glucose oxidase (detection limit 0.9 nM) 13 , and potentiometric methods that associates the electrical conductivity of TiO2-GOx (TiO 2 nanowires with surface-functionalized Glucose oxidase GOx) films with variation of concentrations of Glucose 4 .…”

Section: Introductionmentioning

confidence: 99%

Nanomolar detection of glucose using SERS substrates fabricated with albumin coated gold nanoparticles

et al. 2016

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This work presents the design of substrates for Surface Enhanced Raman Scattering (SERS) using star-like gold nanoparticles synthesized by a wet chemical method. The SERS substrates were used for glucose detection for concentrations as low as 10(-7) M, which represents an enhancement factor (EF) of 10(9), as a result of the hot spot formed by the spike termination and appropriate distribution of the gold nanoparticles. An improvement of two orders of magnitude was obtained by coating the gold nanoparticles with albumin with the configuration: glass/Au nanoparticles/albumin. In this case the lowest detection was at a concentration of 10(-9) M for an EF of 10(11). The albumin molecule allowed us to enhance the Raman signal because of the formation of peptide bonds (COOH-NH2) generated due to the interaction of glucose with albumin, and the appropriate separation distance between the glucose molecules and gold nanoparticles. The presence of such peptide conjugates was confirmed by FTIR spectra. Thus, our results suggest that our SERS substrates can be useful for the detection of very low concentrations of glucose, which is important for the diagnosis of diabetes in the field of medicine.

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RETRACTED ARTICLE: A compact photometer based on metal-waveguide-capillary: application to detecting glucose of nanomolar concentration

Cited by 13 publications

References 43 publications

Highly sensitive detection of thrombin using metal-waveguide-capillary based photometer and gold nanorods probe

Highly sensitive detection of thrombin using metal-waveguide-capillary based photometer and gold nanorods probe

Challenges and perspectives in continuous glucose monitoring

Nanomolar detection of glucose using SERS substrates fabricated with albumin coated gold nanoparticles

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