RETRACTED ARTICLE: Association of the polymorphisms in
            <i>FOXO1</i>
            gene and diabetic nephropathy risk

Ma, Jianxia; Pei, Yong-Bin; Xue, Peng; Wang, Yan; Bao, Xiaoyong; Li, Yukun

doi:10.1080/21691401.2019.1601103

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…The FoxO1/rs2297626 A allele and the AA genotype showed significantly increased frequencies in acute anterior uveitis patients with ankylosing spondylitis [29]. The FoxO1/rs17592236 located in 3′-UTR of the FoxO1 gene and the identified Ars17446614-Crs17592236 haplotype were associated with an increased risk of diabetic nephropathy [30]. Considering these studies, we selected nine single nucleotide polymorphisms (SNPs) in Th17/Treg cell-related genes, including IL2RA, miR27a, miR182, and FoxO1, to explore the association between gene polymorphisms and GD susceptibility in Southwest Chinese Han population.…”

Section: Introductionmentioning

confidence: 95%

“…Based on the available literature studies, we selected nine SNPs, which were earlier shown to be associated with a variety of autoimmune diseases [25][26][27][28][29][30]. Finally, we selected three SNPs (rs3118470, rs2104286, and rs7093069) for IL2RA, one SNP (rs895819) for miR27a, one SNP (rs76481776) for miR182, and four SNPs (rs2297626, rs17592236, rs9549241, and rs12585277) for FoxO1.…”

Section: Selection Of Single Nucleotide Polymorphismsmentioning

confidence: 99%

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Predisposition to Graves’ disease and Graves’ ophthalmopathy by genetic variants of IL2RA

Wang

Tan

et al. 2021

J Mol Med

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Previous studies have identified that Th17/Treg cells were involved in the occurrence and development of Graves' disease (GD). This study aimed at clarifying the association between GD susceptibility and nine single nucleotide polymorphisms (SNPs) of Th17/Treg cell-related genes, including IL2RA, miR27a, miR182, and FoxO1. A two-stage association study was performed in 650 GD patients and 1300 healthy controls. PCR-RFLP assays, real-time PCR, and ELISA were performed. In the first stage, association analysis has identified that IL2RA/rs3118470 TT genotype (Pc = 0.027, OR = 1.688) and IL2RA/rs2104286 AA genotype (Pc = 0.027, OR = 1.658) has significantly increased frequencies in patients with GD than control subjects. In the second stage, the result of rs2104286 was consistent with the first-stage results (AA genotype: Pc = 0.006, OR = 1.618). The combined data showed that IL2RA/rs2104286 AA genotype had increased frequencies in patients with GD (Pc = 8.772 × 10 −6 , OR = 1.636). Stratification analysis also revealed that rs2104286 AA genotype was significantly associated with Graves' ophthalmopathy (GO) susceptibility (Pc = 9.150 × 10 −4 , OR = 1.851). Functional studies showed that carriers of the rs2104286 AA genotype had lower IL2RA mRNA expression than AG genotype carriers (P = 0.021). Cytokine analyses revealed that the rs2104286 AA genotype individuals had lower IL-10 levels (P = 0.015) and increased IL-17 levels than AG genotype carriers (P = 1.467 × 10 −4 ). In conclusion, our findings suggested that IL2RA/rs2104286 was associated with GD and GO susceptibility in Southwest Chinese Han population, which may be involved in the occurrence of GD and GO by affecting the mRNA expression of IL2RA gene and the cytokine production. Key messages• We identified that IL2RA/rs2104286 locus contributed to the predisposition of Graves' disease (GD) and Graves' ophthalmopathy (GO). • Functional analyses suggested that IL2RA/rs2104286 may participate in the occurrence of GD and GO by affecting the mRNA expression of IL2RA and cytokine (IL-10 and IL-17) secretion. • We found that IL2RA (rs3118470, rs7093069), miR27a/ rs895819, miR182/rs76481776, and FoxO1 (rs2297626, rs17592236, rs9549241, rs12585277) loci polymorphisms were not associated with GD susceptibility.

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Section: Introductionmentioning

confidence: 95%

Section: Selection Of Single Nucleotide Polymorphismsmentioning

confidence: 99%

Predisposition to Graves’ disease and Graves’ ophthalmopathy by genetic variants of IL2RA

Wang

Tan

et al. 2021

J Mol Med

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“…However, the exact mechanism regarding the pathophysiology of DKD remains unclear [7]. Clinical and epidemiological studies have shown that there is a family history of DKD in various ethnic groups, suggesting that genetic factors play a key role in developing the disease [8,9].…”

Section: Introductionmentioning

confidence: 99%

Role of engulfment and cell motility 1 (ELMO1) gene polymorphism in development of diabetic kidney disease

Omar

Zewain

Ghonaim

et al. 2021

Egypt J Med Hum Genet

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Background Diabetic kidney disease (DKD) is a progressive kidney disease that affects diabetic patients irrespective of glycemic state or hypertension. Therefore, early detection of DKD is of critical importance. Many genome-wide association studies have identified the engulfment and cell motility 1 (ELMO1) gene as a genetic marker linked to DKD. This study aimed to investigate the association between ELMO1 rs741301 gene polymorphism and the development of DKD among Egyptian patients with type 2 diabetes mellitus (T2DM). Allele and genotype frequencies were investigated in 304 subjects by real-time PCR allelic discrimination assay: 100 DKD patients, 102 diabetic patients without DKD, and 102 healthy controls. Results GG genotype of ELMO1 (rs741301) SNP and its allele frequencies were significantly high in all diabetic patients. GG genotype had an odds ratio (OR) of 6.095 and 95% confidence interval (CI) of 2.456–15.125, p < 0.001, while the frequent allele G had an OR of 2.366 and 95% CI of 1.450–3.859, p = 0.001. No significant difference was observed between T2DM without DKD and DKD. Conclusion Our results could not establish an association between the ELMO1 rs741301 variant and the progression of DKD.

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“…Evidence-Based Complementary and Alternative Medicine FOXO1 gene is located on chromosome 13q14.11 and encodes the FOXO1 protein, which belongs to the FOXO family. FOXO1 could combine with a promoter by shuttling into the nucleus and activate the transcription activity of the target genes [40]. FOXO1 plays multiple important roles in regulating cell homeostasis, glucose metabolism, immune response, cell cycle progression, apoptosis, and aging [14,15].…”

Section: Discussionmentioning

confidence: 99%

Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity

Zhang

Jiao

Song

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. The accumulation of the hepatotoxic substance protoporphyrin IX (PPIX) induced by aminolevulinate synthase 1 (ALAS1) activation is one of the important mechanisms of antituberculosis drug-induced hepatotoxicity (ATDH). Forkhead box protein O1 (FOXO1) may activate ALAS1 transcription. However, little is known about their roles in ATDH; we performed a study to determine the association between polymorphisms in the two genes and ATDH susceptibility. Then, we verified this possible association by cellular functional experiments. Materials and Methods. Tag single-nucleotide polymorphisms (TagSNPs) in the two genes were genotyped in 746 tuberculosis patients. The frequencies of the alleles, genotypes, genetic models, and haplotype distribution of the variants were compared between the case and control groups. L-02 cells and HepG2 cells were incubated with the indicated concentration of isoniazid (INH) and rifampicin (RIF) for the desired times, and then the expression levels of ALAS1 and FOXO1 mRNAs and proteins were detected. HepG2 cells were transiently transfected with FOXO1 siRNA to observe the effect of changes in the FOXO1 expression on the cell survival rate and ALAS1 expression. Results. The C allele at rs2755237 and the T allele at rs4435111 in the FOXO1 gene were associated with a decreased risk of ATDH. The expression of ALAS1 in both L-02 cells and HepG2 cells was increased by the coadministration of INH/RIF (600/200 μM) for 24 h. Although FOXO1 expression was reduced slightly by the same treatment, its content in the nucleus was significantly increased. However, the cell survival rate and ALAS1 expression level were not significantly altered by the downregulation of FOXO1 in HepG2 cells. Conclusions. Variants of the rs4435111 and rs2755237 loci in the FOXO1 gene were associated with susceptibility to ATDH. Coadministration of INH/RIF promoted the transfer of FOXO1 from the cytoplasm to the nucleus, but the functional significance of its nuclear translocation requires further verification.

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RETRACTED ARTICLE: Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk

Cited by 6 publications

References 34 publications

Predisposition to Graves’ disease and Graves’ ophthalmopathy by genetic variants of IL2RA

Predisposition to Graves’ disease and Graves’ ophthalmopathy by genetic variants of IL2RA

Role of engulfment and cell motility 1 (ELMO1) gene polymorphism in development of diabetic kidney disease

Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity

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