RETRACTED ARTICLE: Childhood nosocomial viral acute respiratory tract infections in teaching hospital Anuradhapura, Sri Lanka

Jayaweera, Jayaweera Arachchige Asela Sampath; Reyes, Mohammed

doi:10.1186/s13104-019-4624-2

Cited by 7 publications

(7 citation statements)

References 27 publications

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“…Most frequently reported comorbidities were congenital heart disease, certain genetic disorders such as trisomy 21 (Down syndrome), and neurological disease. These findings are in line with findings from other studies that identified congenital heart disease, Down syndrome, immunodeficiency [6], and prematurity [8] as risk factors for acquiring RSV infection in the hospital. In a Canadian study, children with nosocomial RSV infection were more likely to have preexisting risk factors for severe disease including prematurity, immunodeficiency, lung disease, or heart disease, and stayed longer in the hospital than children with community-acquired RSV infection, which is comparable to our results.…”

Section: Discussionsupporting

confidence: 92%

“…[3] Furthermore, RSV has been reported as the most important viral cause of nosocomial LRTI in children. [4][5][6][7] The proportional contribution of nosocomial RSV mortality to the global RSV mortality burden is expected to be substantial, as nosocomial RSV infection is generally more severe than communityacquired RSV infection. [8][9][10] Currently, several RSV vaccine candidates and monoclonal antibodies are in late phase clinical development.…”

Section: Introductionmentioning

confidence: 99%

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Nosocomial RSV-related in-hospital mortality in children <5 years: a global case series

Löwensteyn

Willemsen

Scheltema

et al. 2022

Preprint

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Background According to the World Health Organization the global burden of nosocomial infections is poorly characterized as surveillance systems for nosocomial infection are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired disease. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. Methods RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. Results We included 231 nosocomial and 931 community-acquired RSV-related in-hospital deaths from 65 countries. Median age at death was similar for both groups (5.4 vs 6 months). As expected, a higher proportion of children with nosocomial infection had comorbidities (87% vs 57%; p<0.001) or was born preterm (46% vs 24%; p<0.001) than children with community-acquired infection. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs 18% and 26%, respectively). Conclusions This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies can prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Nosocomial RSV-related in-hospital mortality in children <5 years: a global case series

Löwensteyn

Willemsen

Scheltema

et al. 2022

Preprint

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“…In some studies, RSV detection was more than 3 times greater than the next leading pathogen [ 14 ]. Reported RSV positivity rates in tropical Asian countries range from 9% to 50% depending on the geographic location and sample population ( Table 1 ) [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Not unexpectedly, an increased risk for RSV infection has been noted in infants with chronic lung disease, neurodevelopmental conditions and congenital heart disease, with repeated infections associated with asthma and atopy among the children and their families [ 15 ].…”

Section: Rsv Disease Activity Across Tropical Asiamentioning

confidence: 99%

Epidemiology and Seasonality of Childhood Respiratory Syncytial Virus Infections in the Tropics

Suryadevara

Domachowske

2021

Viruses

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Infections caused by respiratory syncytial virus (RSV) are a major cause of morbidity and mortality in young children worldwide. Understanding seasonal patterns of region-specific RSV activity is important to guide resource allocation for existing and future treatment and prevention strategies. The decades of excellent RSV surveillance data that are available from the developed countries of the world are incredibly instructive in advancing public health initiatives in those regions. With few exceptions, these developed nations are positioned geographically across temperate regions of the world. RSV surveillance across tropical regions of the world has improved in recent years, but remains spotty, and where available, still lacks the necessary longitudinal data to determine the amount of seasonal variation expected over time. However, existing and emerging data collected across tropical regions of the world do indicate that patterns of infection are often quite different from those so well described in temperate areas. Here, we provide a brief summary regarding what is known about general patterns of RSV disease activity across tropical Asia, Africa and South America, then offer additional country-specific details using examples where multiple reports and/or more robust surveillance data have become available.

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“…A study done in intensive care presented a prevalence of HAI of 41.58% (n=42) (Pemasinghe, et al, 2012). whereas in another study, childhood healthcare associated respiratory syncytial viral RTI were detected in 86 out of total of 818 (Jayaweera & Reyes, 2019). A study conducted in Uganda showed the total prevalence of HAIs as 28% suggesting better health care in local settings .…”

Section: Discussionmentioning

confidence: 89%

Proportion of Three Types of Health Care Associated Infections among Hospitalized Patients in a Tertiary Care Hospital in Sri Lanka

Marapana

Dilrukshi

Bandara

et al. 2021

IJKIU

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Health care associated infections are considered as an indicator of quality and safety of health care institutions. The study aimed to determine the proportion of health care associated urinary tract infections, respiratory tract infections, surgical site infections, and to evaluate the association of medical devices and duration of hospitalization which predispose to health care associated infections. Four hundred and twenty three patients who stayed more than 48 hours or readmitted to surgical, medical, pediatric and gynecology wards in a tertiary care hospital in Sri Lanka during the study period were included in the study. Data extraction sheets were used and were filled with information obtained from bed head tickets and laboratory reports. A total of 79 (18.7%) patients had been diagnosed to have health care associated infection. The predominant type was respiratory tract infections 24 (30.4%) followed by urinary tract infections 21(26.6%), surgical site infections 17 (21.5%), and other infections 17 (21.5%). The highest proportion of urinary tract infections were seen in surgical wards (38.1%) whereas the highest proportion of respiratory tract infections were seen in medical wards (45.8%). Patients aged more than 60 were found to be affected most (27/94). Health care associated infections were significantly associated with usage of medical devices (p<0.05) and length of stay in hospital (p<0.05). The study concludes that these infections account for a noteworthy percentage in hospitalized patients and the predominant type was respiratory tract infections in this tertiary care hospital in Sri Lanka and elders were the mostly affected category compared to children and adults age groups.

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RETRACTED ARTICLE: Childhood nosocomial viral acute respiratory tract infections in teaching hospital Anuradhapura, Sri Lanka

Cited by 7 publications

References 27 publications

Nosocomial RSV-related in-hospital mortality in children <5 years: a global case series

Nosocomial RSV-related in-hospital mortality in children <5 years: a global case series

Epidemiology and Seasonality of Childhood Respiratory Syncytial Virus Infections in the Tropics

Proportion of Three Types of Health Care Associated Infections among Hospitalized Patients in a Tertiary Care Hospital in Sri Lanka

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