RETRACTED ARTICLE: Chitosan/Pectin Nanoparticles Encapsulated with Echinacea pallida: a Focus on Antibacterial and Antibiofilm Activity Against Multidrug-Resistant Staphylococcus aureus

Ghajari, Ghazal; Naser, Rana Hussein; Pecho, Renzon Daniel Cosme; Alhili, Farah; Piri-Gharaghie, Tohid

doi:10.1007/s12010-023-04709-1

Appl Biochem Biotechnol

2023

DOI: 10.1007/s12010-023-04709-1

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RETRACTED ARTICLE: Chitosan/Pectin Nanoparticles Encapsulated with Echinacea pallida: a Focus on Antibacterial and Antibiofilm Activity Against Multidrug-Resistant Staphylococcus aureus

Ghazal Ghajari,

Rana Hussein Naser,

Renzon Daniel Cosme Pecho

et al.

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2024

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Cited by 4 publications

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Fabrication and antimicrobial properties of novel meropenem‐honey encapsulated chitosan nanoparticles against multiresistant and biofilm‐forming Staphylococcus aureus as a new antimicrobial agent

Hajimohammadi,

Momtaz,

Tajbakhsh

2024

Veterinary Medicine & Sci

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BackgroundHoney exhibits a broad spectrum of antibacterial activity against Gram‐positive and Gram‐negative bacteria, including methicillin‐resistant Staphylococcus aureus (MRSA) ones. Chitosan (Cs) is a mucoadhesive polymer that also has antibacterial properties. Special attention has been paid to the design of polymeric nanoparticles (NPs) as new nano drug delivery systems to overcome bacterial resistance and its problems.ObjectivesThe aim of the present study is to synthesize Cs‐meropenem NPs with/without honey as an antibiofilm and antibacterial agent to inhibit Staphylococcus aureus.MethodsThis study synthesized meropenem and honey‐loaded Cs nanogels and subsequently characterized them by Field Emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared Spectroscopy (FTIR), and DLS‐zeta potential. Using the broth microdilution and crystal violet assays, the antibacterial and antibiofilm activity of meropenem and honey‐loaded Cs nanogel, free meropenem, free honey, and free Cs NPs were investigated in vitro against MRSA strains. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) was also used to test the cytotoxicity of several Cs‐NPs compound against the HEK‐293 regular cell line.ResultsThe average size of meropenem and honey‐Cs‐NPs was reported to be 119.885 nm, and encapsulation efficiency was 88.33 ± 0.97 with stability up to 60 days at 4°C. The NPs showed enhanced antibiofilm efficacy against S. aureus at sub‐minimum inhibitory concentrations. Additionally, the cytotoxicity of meropenem and honey‐encapsulated Cs against the HEK‐293 normal cell line was insignificant.ConclusionsOur findings suggested that meropenem and honey‐Cs‐NPs might be potential antibacterial and antibiofilm materials.

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Fabrication and antimicrobial properties of novel meropenem‐honey encapsulated chitosan nanoparticles against multiresistant and biofilm‐forming Staphylococcus aureus as a new antimicrobial agent

Hajimohammadi,

Momtaz,

Tajbakhsh

2024

Veterinary Medicine & Sci

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Limonene encapsulated alginate/collagen as antibiofilm drug against Acinetobacter baumannii

Valookolaei,

Sazegar,

Rouhi

2024

BMC Biotechnol

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Chitosan-casein as novel drug delivery system for transferring Phyllanthus emblica to inhibit Pseudomonas aeruginosa

Ramezani,

Sazegar,

Rouhi

2024

BMC Biotechnol

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This study investigated the ability of Phyllanthus emblica encapsulated within chitosan-coated casein (CS-casein-Amla) nanoparticles to inhibit the growth of multi-drug-resistant Pseudomonas aeruginosa ( P. aeruginosa) bacteria and prevent the formation of biofilms. The MDR strains underwent screening, and the morphological characteristics of the resulting nanoparticles were assessed using SEM, DLS, and FTIR. In addition, the efficacy of encapsulation, stability, and drug release were evaluated. The PpgL , BdlA , and GacA biofilm gene transcription quantities were quantified by quantitative real-time PCR. Simultaneously, the nanoparticles were assessed for their antibacterial and cytotoxic effects using the well diffusion and MTT procedures. CS-casein-Amla nanoparticles with a size of 500.73 ± 13 nm, encapsulation efficiency of 76.33 ± 0.81%, and stability for 60 days at 4 °C (Humidity 30%) were created. The biological analysis revealed that CS-casein-Amla nanoparticles exhibited strong antibacterial properties. This was shown by their capacity to markedly reduce the transcription of PpgL , BdlA , and GacA biofilm genes at a statistically significant value of p ≤ 0.01. The nanoparticles demonstrated decreased antibiotic resistance compared to unbound Amla and CS-casein. Compared to Amla, CS-casein-Amla nanoparticles showed very little toxicity against HDF cells at dosages ranging from 1.56 to 100 µg/mL ( p ≤ 0.01). The results highlight the potential of CS-casein-Amla nanoparticles as a significant advancement in combating highly resistant P. aeruginosa . The powerful antibacterial properties of CS-casein-Amla nanoparticles against P. aeruginosa MDR strains, which are highly resistant pathogens of great concern, may catalyze the development of novel antibacterial research approaches. Supplementary Information The online version contains supplementary material available at 10.1186/s12896-024-00907-9.

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RETRACTED ARTICLE: Chitosan/Pectin Nanoparticles Encapsulated with Echinacea pallida: a Focus on Antibacterial and Antibiofilm Activity Against Multidrug-Resistant Staphylococcus aureus

Cited by 4 publications

References 46 publications

Fabrication and antimicrobial properties of novel meropenem‐honey encapsulated chitosan nanoparticles against multiresistant and biofilm‐forming Staphylococcus aureus as a new antimicrobial agent

Fabrication and antimicrobial properties of novel meropenem‐honey encapsulated chitosan nanoparticles against multiresistant and biofilm‐forming Staphylococcus aureus as a new antimicrobial agent

Limonene encapsulated alginate/collagen as antibiofilm drug against Acinetobacter baumannii

Chitosan-casein as novel drug delivery system for transferring Phyllanthus emblica to inhibit Pseudomonas aeruginosa

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