RETRACTED ARTICLE: Chronic and progressive dopaminergic neuronal death in substantia nigra associates with a decrease in serum levels of glucose and free fatty acids, the role of interlokin-1 beta

Sarbazi-Golezari, Ali; Haghdoost-Yazdi, Hashem

doi:10.1007/s11011-021-00868-4

Cited by 1 publication

(2 citation statements)

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“…It has been revealed that degeneration of dopaminergic neurons in the SN influences glycaemic control since SN regulates the feeding behaviour during hypoglycaemia 45 . This conclusion anticipated the mutual relationship between T2DM and PD 37,46 …”

Section: T2dm and Inflammatory Disordersmentioning

confidence: 78%

“…45 This conclusion anticipated the mutual relationship between T2DM and PD. 37,46 A prospective study on 25 PD patients with T2DM compared to 25 PD patients without T2DM followed for 36 months showed that T2DM patients with PD experience more motor dysfunctions. 22 The incidence of PD in the general population is 0.03% though this percentage is augmented to 18% in T2DM patients.…”

Section: T2dm and The Risk Of Pdmentioning

confidence: 99%

See 1 more Smart Citation

NF‐κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective

Alrouji

Al-Kuraishy

Al-Gareeb

et al. 2023

J Cellular Molecular Medi

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Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease (AD). Genetic predisposition and immune dysfunction are involved in the pathogenesis of PD. Notably, peripheral inflammatory disorders and neuroinflammation are associated with PD neuropathology. Type 2 diabetes mellitus (T2DM) is associated with inflammatory disorders due to hyperglycaemia-induced oxidative stress and the release of pro-inflammatory cytokines. Particularly, insulin resistance (IR) in T2DM promotes the degeneration of dopaminergic neurons in the substantia nigra (SN). Thus, T2DM-induced inflammatory disorders predispose to the development and progression of PD, and their targeting may reduce PD risk in T2DM.

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Section: T2dm and Inflammatory Disordersmentioning

confidence: 78%