“…On the other hand, Suresh et al [ 49 ] and Sapate et al [ 50 ] employ a fuzzy-based strategy to cluster all the pixels with similar features in order to detect all the zones that have differences. Other strategies involve the utilization of mathematical morphology [ 51 , 52 , 53 , 54 , 55 ], image contrast and intensity [ 56 , 57 ], geometrical features [ 58 , 59 ], correlation and convolution [ 60 , 61 ], non-linear filtering [ 62 , 63 ], texture features [ 64 ], deep learning [ 65 , 66 , 67 , 68 , 69 ], entropy [ 70 , 71 ], among other strategies. It is worth noticing that from the diversity of the employed strategies, some of them still require an initial guidance to detect the suspicious zones, either by manually selecting pixels inside of the zone or using the radiologist notes about the localization.…”