RETRACTED ARTICLE: Clinical significance and expression of the PRSS3 and Wiskott–Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer

Azizmohammadi, Sima; Safari, Aghdas; Seifoleslami, Mehri; Rabati, Rahman Ghaffarzadegan; Mohammadi, Mohsen; Yahaghi, Hamid; Azizmohammadi, Susan

doi:10.1007/s13277-015-4586-5

Cited by 2 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Trypsin belongs to the serine protease family and was recently found to be an important driver in several pathophysiological context including cancer initiation. 7 It was acknowledged that trypsin was derived from the trypsinogen, which was synthesized in the pancreas as an inactive precursor and then activated in the gastrointestinal tract. 8 And the cancer-related synthesis of trypsinogen has been identified in various types of tumor, which was indicated to be essential for carcinogenesis.…”

mentioning

confidence: 99%

“…It has been previously reported that dysfunction of serine proteases might contribute to the development of malignant tumors 6. Trypsin belongs to the serine protease family and was recently found to be an important driver in several pathophysiological context including cancer initiation 7. It was acknowledged that trypsin was derived from the trypsinogen, which was synthesized in the pancreas as an inactive precursor and then activated in the gastrointestinal tract 8.…”

mentioning

confidence: 99%

See 1 more Smart Citation

High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma

Zhang

Ji-hai

Huang

et al. 2021

Applied Immunohistochemistry &Amp; Molecular Morphology

View full text Add to dashboard Cite

Introduction: Serine proteases have been implicated as key drivers and facilitators of cancer malignancy. Protease, serine, 3 (PRSS3), which belongs to the serine proteases family, is reported to be abundantly expressed in a variety of types of tumor and contributes to the initiation and development of cancers. However, the clinical role of PRSS3 in colon adenocarcinoma (CAC) was not clarified yet.In the present study, we explored the potential effect of PRSS3 in CAC and whether it is related to the poor survival of CAC patients. Materials and Methods:The mRNA and protein levels of PRSS3 were examined in CAC samples and connective noncancerous colon samples through quantitative real-time polymerase chain reaction assay and immunohistochemistry staining. Univariate and multivariate analyses were performed to estimate the prognostic role of PRSS3 in enrolled CAC patients.Results: PRSS3 expression in CAC samples was significantly increased compared with connective noncancerous samples. Moreover, a higher level of PRSS3 was found to be correlated with the larger tumor size, advanced T stage, and positive lymph node metastasis. In addition, PRSS3 was also defined as an unfavorable prognosis factor for CAC patients.Conclusions: High expression of PRSS3 was significantly related to the unfavorable clinical features and poor prognosis in CAC patients. It suggested that PRSS3 might serve as a novel prognostic indicator and potential drug target for CAC treatment.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma

Zhang

Ji-hai

Huang

et al. 2021

Applied Immunohistochemistry &Amp; Molecular Morphology

View full text Add to dashboard Cite

show abstract

“…PRSS3 was expressed in both ovarian epithelial cancer and benign ovarian tumors, but its expression was significantly higher in ovarian epithelial cancer [31–32]. Hockla et al [33–36].…”

Section: Discussionmentioning

confidence: 99%

PRSS3 is a prognostic marker in invasive ductal carcinoma of the breast

Gao

Hua

et al. 2017

Oncotarget

View full text Add to dashboard Cite

ObjectiveSerine protease 3 (PRSS3) is an isoform of trypsinogen, and plays an important role in the development of many malignancies. The objective of this study was to determine PRSS3 mRNA and protein expression levels in invasive ductal carcinoma of the breast and normal surrounding tissue samples.ResultsBoth PRSS3 mRNA and protein levels were significantly higher in invasive ductal carcinoma of the breast tissues than in normal or benign tissues (all P < 0.05). High PRSS3 protein levels were associated with patients’ age, histological grade, Her-2 expression level, ki-67 expression, and the 5.0-year survival rate. These high protein levels are independent prognostic markers in invasive ductal carcinoma of the breast.Materials and MethodsWe used real-time quantitative polymerase chain reactions (N = 40) and tissue microarray immunohistochemistry analysis (N = 286) to determine PRSS3 mRNA and protein expression, respectively. PRSS3 protein levels in invasive ductal carcinoma of the breast tissues were correlated with the clinical characteristics of patients with invasive ductal carcinoma of the breast and their 5.0-year survival rate.ConclusionsPRSS3 acts as an oncogene in invasive ductal carcinoma of the breast development and progression. This finding implies that detection of PRSS3 expression can be a useful prognosis marker and the targeting of PRSS3 can potentially represent a new strategy for invasive ductal carcinoma of the breast treatment.

show abstract

RETRACTED ARTICLE: Clinical significance and expression of the PRSS3 and Wiskott–Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer

Cited by 2 publications

References 27 publications

High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma

High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma

PRSS3 is a prognostic marker in invasive ductal carcinoma of the breast

Contact Info

Product

Resources

About