RETRACTED ARTICLE: Determination of acetaminophen spatial distribution and content in tablets using confocal micro-Raman spectroscopy mapping

Jiang, Hongyu; Ding, Changhong; Wang, Yue; Zhang, Yingxin; Mohammed, Ahmed; Pan, Yan; Han, Bing

doi:10.1007/s11051-020-04970-z

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…[11][12][13][14] Apart from membranes or films, the liquid-liquid phase separation and BF techniques have been applied to electrospinning for preparing porous fibers. [15][16][17][18][19] In NIPS, the phase separation is induced either by premixed nonsolvents [20][21][22][23][24][25] or by posttreatment with nonsolvents. [26][27][28] For the TIPS method, the solvent quality is turned to be poorer to polymers by lowering the temperature to cause a phase separation.…”

Section: Introductionmentioning

confidence: 99%

Macroporous fibers electrospun from dual‐good solvent system

Chen

Chang

Liao

et al. 2023

Journal of Polymer Science

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The polymer/solvent/nonsolvent ternary solutions have been previously used for fabricating electrospun macroporous fibers, in which the nonsolvent was expected to induce a liquid–liquid phase separation that leads to formation of pores after drying. In this study, we demonstrate that the poly(styrene‐co‐acrylonitrile) (SAN)/chlorobenzene (CB)/dimethyl sulfoxide (DMSO) system can be successfully electrospun into highly uniform macroporous fibers with pore size >50 nm at CB/DMSO volume ratio ~7/3 though both CB and DMSO are good solvents to SAN. The results imply that a premixed nonsolvent is not necessary for the formation of macropores. We find that it is the water droplets condensed from the atmosphere that work as the nucleation sites to trigger the phase separation while water‐miscible DMSO plays a supporting role to expand the solvent‐rich phase and the resultant pore size. Instead of solvent quality, the distinct volatilities and water miscibilities of the solvents are the keys. The macropores throughout the fibers provide high surface areas and large openings on surface such that the fibers show a significant improvement in oil adsorption capacity in comparison to the smooth and mesoporous ones.

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Section: Introductionmentioning

confidence: 99%

Macroporous fibers electrospun from dual‐good solvent system

Chen

Chang

Liao

et al. 2023

Journal of Polymer Science

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“…It is also a practical method for identification and verification of known components and the determination of the impurities in pharmaceuticals. In this context, many studies based on Raman and FT Raman spectroscopic techniques have previously been carried out for the quantitative determination and validation of many drugs in liquid or solid pharmaceutical formulations 9,10,[14][15][16][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] .…”

Section: Introduction: Paracetamol (Pct) or Acetaminophenmentioning

confidence: 99%

Untitled

2022

IJPSR

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In this study, Raman spectroscopy was used as an analytical quality control methodology to evaluate the paracetamol (PCT) quantity in a commercially available formulation in the pharmaceutical industry. The Raman Spectroscopy has been established for the validation and the quantification of PCT in a commercial product called Paracerol (Prc) Solution for I.V. Infusion containing 10.0 mg.mL -1 PCT. The validation of the proposed method was performed by evaluating the specificity, linearity range, accuracy, precision, detection limit, quantification limit, and robustness parameters. The acceptable results for all parameters showed that the proposed method is valid. The Raman spectroscopic method was also compared with the HPLC method in terms of PCT determination and statistical tests such as t and F tests and the obtained results indicated that there is no any difference in the averages and precision results between the proposed Raman spectroscopy and HPLC methods. It has been reported that Raman spectroscopy can be applied in the pharmaceutical industry for the quality control analysis of the commercial formulation of PCT.

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Spatial distribution and content determination of Ganoderic acid F in tablets using confocal Raman microspectroscopy

Zhang

Sun

et al. 2020

J Ambient Intell Human Comput

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RETRACTED ARTICLE: Determination of acetaminophen spatial distribution and content in tablets using confocal micro-Raman spectroscopy mapping

Cited by 4 publications

References 17 publications

Macroporous fibers electrospun from dual‐good solvent system

Macroporous fibers electrospun from dual‐good solvent system

Untitled

Spatial distribution and content determination of Ganoderic acid F in tablets using confocal Raman microspectroscopy

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