RETRACTED ARTICLE: Evaluation of ferritin level in COVID-19 patients and its inflammatory response

Chen, Jing; He, Zhengxin; Wang, Fun-kun

doi:10.1007/s13204-021-02115-9

Cited by 9 publications

(6 citation statements)

References 58 publications

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“…The possible molecular mechanism lying behind is associated with ACE2, one of the SARS-CoV-2 binding receptors widely present in GI epithelial cells [ 58 , 59 ]. The interaction among Spike proteins found on the surface of SARS-CoV-2 and ACE2 causes damage to GI epithelial cells, resulting in the loss of function of ACE2, which further produces micro ecological imbalance, intestinal inflammation, and immune disorders [ 60 , 61 ].…”

Section: Sars-cov-2 and Gastrointestinal Systemmentioning

confidence: 99%

SARS‐CoV‐2 infection and multi-organ system damage: a review

Rabaan

Smajlović

Tombuloğlu

et al. 2022

Bosn J of Basic Med Sci

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The BJBMS publishes an "Advanced online" manuscript format as a free service to authors in order to expedite the dissemination of scientific findings to the research community as soon as possible after acceptance following peer review and corresponding modification (where appropriate). An "Advanced online" manuscript is published online prior to copyediting, formatting for publication and author proofing, but is nonetheless fully citable through its Digital Object Identifier (doi®). Nevertheless, this "Advanced online" version is NOT the final version of the manuscript.

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Section: Sars-cov-2 and Gastrointestinal Systemmentioning

confidence: 99%

SARS‐CoV‐2 infection and multi-organ system damage: a review

Rabaan

Smajlović

Tombuloğlu

et al. 2022

Bosn J of Basic Med Sci

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“…The recommended cutoffs for ferritin are 109.8 ng/mL, WBC is 14.9109/L, CRP 10.15 is mg/L, and LDH is 229.33 U/L as per a study in China. [15,16] In this case series, only higher TLC predicted a COVID sepsis but other parameters were similar among all four cases but had severe disease.…”

Section: Discussionmentioning

confidence: 55%

COVID-19 Pregnancies with Heart Disease: Challenges of Delivery

Anant

Kumar

Ahmad

2022

IJCDW

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This case series of four cases of pregnancy with rheumatic heart disease with COVD-19 disease reports on the management of delivery and complications of heart disease with COVID-19, high-lighting the presentation, severity, delivery concerns, and clinical management with the maternal and fetal outcomes. Of the four full-term deliveries, one delivered normally, one instrumental delivery and two by cesarean section. All four required oxygen support post-delivery, 2/4 (50%) were transferred for intensive care unit (ICU) care, 1/4 (25%) required mechanical ventilation, 1/4 (25%) had postpartum hemorrhage, 1/4 (25%) had COVID related sepsis and received convalescent plasma therapy, and 2/4 (50%) received antiviral remdesivir. The most severe disease (COVID sepsis and ICU stay) was seen in patient of heart disease with COVID with preclampsia. All neonates tested SARS-CoV-2 negative, with one early neonatal death. All four mothers were discharged in stable condition of COVID and heart status. COVID-19 in cardiac disease pregnancies has increased rates of complications, oxygen, and ICU requirements than other pregnancies with COVID, requiring multidisciplinary team for intensive monitoring of intrapartum and postpartum period.

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“…Several studies showed controversial results regarding ferritin levels in men and women infected by COVID-19. A study performed by J. Chen et al has shown higher mean ferritin levels in females (598.74 ng/mL) than in males (511.21 ng/mL) among patients with COVID-19 [17]. However, another study has shown higher ferritin levels in males (1024.54 μg/L) than in females (531.13 μg/L) (P < 0.001) [18].…”

Section: Discussionmentioning

confidence: 94%

Ferritin level predicts in-hospital mortality in hypertensive patients with COVID-19

Skakun

Seredyuk

2023

ZMJ

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Aim. This study aimed to establish the predictive ability of serum ferritin levels for severe / critical condition development, need for supplemental oxygen, and in-hospital mortality in hypertensive patients with COVID-19-associated pneumonia. Materials and methods. 135 unvaccinated patients hospitalized for COVID-19-associated pneumonia were enrolled in the study. 78.5 % of patients were hypertensive. Results. Among hypertensive patients, the median ferritin level at admission was 315.5 (169.0–396.0) ng/mL in patients with moderate condition, 374.0 (171.0–709.5) ng/mL in patients developed severe condition, and 489.0 (362.0–1128.5) ng/mL in patients developed critical condition (P = 0.03). Serum ferritin level at admission was higher in non-survivors (539.0 (440.0–1128.5) ng/mL) than that in survivors (332.5 (172.0–545.0) ng/mL, P = 0.02). Hypertensive patients who required supplemental oxygen had higher median serum ferritin level (446.0 (187.0–763.0) ng/mL) than patients without the requirement of supplemental oxygen (324.0 (165.0–401.0) ng/mL, P = 0.02). There was poor discrimination ability of ferritin level in the prediction of severe / critical conditions (AUC = 0.628, P = 0.02) and the need for supplemental oxygen (AUC = 0.629, P = 0.02). There was an acceptable discrimination ability of ferritin level in the in-hospital mortality prediction (AUC = 0.701, P = 0.03); the Youden index was 0.54, the associated criterion was >438.0 ng/mL with 83.3 % sensitivity and 70.7 % specificity. Ferritin level >438.0 ng/mL at admission was associated with a significant increase in in-hospital mortality (OR = 12.04 (2.47–58.62), P = 0.002). Conclusions. Serum ferritin level at hospital admission increases with the severity of COVID-19 in hypertensive patients. Serum ferritin level predicts in-hospital mortality in hypertensive patients. However, its predictive ability for the disease progression to severe/critical conditions and the need for supplemental oxygen is poor. A ferritin level of 438.0 ng/mL is proposed to be a cut-off value for the prediction of in-hospital mortality.

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RETRACTED ARTICLE: Evaluation of ferritin level in COVID-19 patients and its inflammatory response

Cited by 9 publications

References 58 publications

SARS‐CoV‐2 infection and multi-organ system damage: a review

SARS‐CoV‐2 infection and multi-organ system damage: a review

COVID-19 Pregnancies with Heart Disease: Challenges of Delivery

Ferritin level predicts in-hospital mortality in hypertensive patients with COVID-19

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