RETRACTED ARTICLE: FeNi nanotubes: perspective tool for targeted delivery

Abstract

Targeted delivery of drugs and proteins by magnetic field is a promising method to treat cancer that reduces undesired systemic toxicity of drugs. In this method, the therapeutic agent is attached through links to functional groups with magnetic nanostructure and injected into the blood to be transported to the problem area. To provide a local effect of drug treatment, nanostructures are concentrated and fixed in the selected area by the external magnetic field (magnet). After the exposure, carriers are removed from the circulatory system by magnetic field. In this study, Fe 20 Ni 80 nanotubes are considered as carriers for targeted delivery of drugs and proteins. A simple synthesis method is proposed to form these structures by electrodeposition in PET template pores, and structural and magnetic properties are studied in detail. Nanotubes have polycrystalline walls providing mechanical strength of carriers and magnetic anisotropy that allow controlling the nanostructure movement under the exposure of by magnetic field. Moreover, potential advantages of magnetic nanotubes are discussed in comparison with other carrier types. Most sufficient of them is predictable behavior in magnetic field due to the absence of magnetic core, low specific density that allows floating in biological media, and large specific surface area providing the attachment of a larger number of payloads for the targeted delivery. A method of coating nanotube surfaces with PMMA is proposed to exclude possible negative impact of the carrier material and to form functional bonds for the payload connection. Cytotoxicity studies of coated and uncoated nanotubes are carried out to understand their influence on the biological media.

Electrochemical Behaviour of Ti/Al2O3/Ni Nanocomposite Material in Artificial Physiological Solution: Prospects for Biomedical Application

“…[1][2][3][4][5][6]). Magnetic nanostructures find various applications in biomedicine, such as targeted drug delivery controlled by an external magnetic field [7][8][9]. Targeted drug delivery is a developing and promising technique for the treatment of cancer.…”

Investigation of the Structural Changes and Catalytic Properties of FeNi Nanostructures as a Result of Exposure to Gamma Radiation

“…At the same time, when irradiated with electronic and gamma radiation, the probability of an increase in the geometric dimensions of nanostructures is extremely small, which indicates the great promise of these types of radiation for directional modification and reduction of the disequilibrium of structural parameters in nanomaterials [16][17][18][19][20]. The absence of oxidation processes as a result of phase transformations upon irradiation with electrons or gamma rays opens up wide possibilities for using these types of radiation for the directed modification of iron-nickel or iron-containing nanostructures, for which oxidation processes are accompanied by phase transformations and changes in properties [21][22][23][24][25]. Permalloy compounds, which have high magnetic permeability, low coercivity and magnetostriction, which classifies them as soft magnetic materials, are some of the most promising materials among iron-containing nanostructures [26][27][28][29][30].…”

Synthesis of gold nanostructures using wet chemical deposition in SiO2/Si template

“…The shape and size of particles depend on the synthesis parameters, such as concentration and temperature of active solutions, deposition time, etc. [9,10]. Using of the template synthesis method allows one to effectively control the deposition of NSs by varying the listed parameters [11][12][13][14][15].…”