RETRACTED ARTICLE: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats

Lamidi, Ibrahim Yusuf; Mikail, Hudu Garba; Adamu, Sani; Akefe, Isaac Oluwatobi; Mohammed, Tareq Abed; Salihu, Sabo Isa; Olatunji, Aisha Omobolanle; Hassan, Abdussalam; Daniel, N.; Adegoke, Victoria Aderonke

doi:10.1007/s43188-020-00084-9

Cited by 9 publications

(3 citation statements)

References 50 publications

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“…The dynamics of antioxidants and oxidants in neural metabolism is well documented [ 14 , 30 , [48] , [49] , [50] , [51] , [52] ]. However, studies investigating agents that capable of disrupting these metabolic processes remain ongoing.…”

Section: Discussionmentioning

confidence: 99%

Myrtenal improves memory deficits in mice exposed to radiofrequency-electromagnetic radiation during gestational and neonatal development via enhancing oxido-inflammatory, and neurotransmitter functions

Akefe¹,

Nyan²,

Adegoke³

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Myrtenal improves memory deficits in mice exposed to radiofrequency-electromagnetic radiation during gestational and neonatal development via enhancing oxido-inflammatory, and neurotransmitter functions

Akefe¹,

Nyan²,

Adegoke³

et al. 2023

Heliyon

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“…Keduanya bekerja secara sinergis untuk menghasilkan efek vasokonstriksi yang dengan aksi noradrenalin pada dinding vena. Hal ini berarti diosmin dan hesperidin dapat menyempitkan pembuluh darah vena, meningkatkan aliran balik vena, dan mengurangi tekanan vena, yang seringkali menjadi faktor penting dalam masalah vaskular [18], [19].…”

Section: Hasil Dan Pembahasanunclassified

"Analisis Senyawa Flavonoid pada Jeruk Manis (Citrus sinensis L.) sebagai Pengobatan Wasir"

Komang Dian Merta Sari Dewi,

Ni Made Widi Astuti

2023

WSNF

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Wasir adalah ketika pembuluh darah normal di daerah rektum mengalami pembengkakan dan pergeseran. Tanda-tanda umum meliputi pendarahan saat melakukan buang air besar dan tonjolan di sekitar anus. Ada cara-cara untuk mencegah wasir tanpa menggunakan obat, seperti meningkatkan asupan serat, menjaga tubuh terhidrasi dengan baik, dan menghindari menunda buang air besar. Suplemen nutrasetikal dapat digunakan sebagai bagian dari pendekatan nonfarmakologi, dengan salah satu contohnya adalah ekstrak dari Citrus sinensis L. yang mengandung flavonoid seperti diosmin dan hesperidin, yang dapat bermanfaat dalam mengatasi kondisi ini. Diosmin-Hesperidin digunakan sebagai terapi untuk gejala wasir. Tujuan review artikel ini adalah untuk mengetahui pemanfaatan senyawa flavonoid dalam pengobatan wasir. Metode yang digunakan pada pembuatan artikel review ini yaitu studi pustaka. Pustaka yang digunakan merupakan jurnal nasional maupun internasional yang membahas mengenai penggunaan senyawa flavonoid untuk pengobatan wasir yang dipublikasikan secara online dari berbagai situs seperti Google Scholar, Science Direct, Researchgate, Pubmed, dan Springerlink. Hasil menunjukkan bahwa kedua senyawa tersebut memiliki efek vasokonstriktor yang memperkuat aliran balik vena, melindungi mikrosirkulasi, dan meningkatkan drainase limfatik. Keduanya umum digunakan bersama untuk mengobati penyakit vena kronis dan hemoroid. Diosmin dihasilkan dari hesperidin dan keduanya memiliki sifat venotonik dan vasoprotektif. Dalam farmakokinetika, Diosmin diserap dalam 1 jam, didistribusikan dalam tubuh, dan diekskresikan melalui feses dan urin. Dapat disimpulkan bahwa flavonoid dari Jeruk manis memiliki efek antioksidan, analgesik, dan anti-inflamasi dengan menghambat mediator inflamasi. Kombinasi Diosmin dan Hesperidin, diisolasi dari buah Citrus, digunakan untuk mengatasi gangguan peredaran darah wasir, mengurangi reaksi peradangan, dan menurunkan rasa nyeri pada hemoroid.

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“…Furthermore, no side effects or unfavorable changes in urine or blood were detected in a trial of 86 overweight humans who received 1420 mg/day of pomegranate fruit extract in tablet form for 28 days [ 12 , 14 ]. Indeed, pomegranate has several therapeutic and pharmacological properties, which may be ascribed to the presence of numerous phytochemicals including phenolic acids, flavonoids, alkaloids phytocompounds, organic acids, gallotannins, anthocyanidins, ellagitannins, flavonones, flavonols, anthocyanins, fatty acids and lipids, and lignans have been isolated from pomegranate [ 10 , 15 , 16 , 17 , 18 ]. Anthocyanins, tannins, and catechins in pomegranate juice and peel also have a significant antioxidant activity [ 10 , 11 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model

et al. 2022

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Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types of cancers. However, it has been associated with nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) is a potent antioxidant and anti-inflammatory agent effective against cancer, with a superior benefit of not being associated with the common toxicities related to the use of conventional chemotherapeutic agents. However, the application of PE is limited by its reduced solubility and decreased bioavailability. We investigated the potential of a novel nanoparticle (NP) enclosing PE to enhance its solubility and improve its bioavailability, and efficacy to prevent CISP-associated nephrotoxicity in a mice model of Ehrlich solid carcinoma (ESC). All mice were grouped into four cohorts: (I) control, (II) tumor, (III) CISP, and (IV) CISP + PE-NPs. The data obtained demonstrated that PE-NPs was beneficial in potently ameliorating CISP-induced nephrotoxicity in ESC mice. PE-NPs significantly attenuated CISP-induced oxidative stress and lipid peroxidation in the kidney via improving activities of antioxidants (SOD, GSH, and CAT). Additionally, PE-NPs considerably decreased CISP-induced inflammation in the kidney by decreasing the levels of NF-kB, IL-1β, and TNF-α. Notably, PE-NPs did not assuage the antitumor efficacy of CISP as revealed by histological assessment and tumor weight data. In summary, PE-NPs may be a potent alternative anticancer therapy devoid of nephrotoxicity.

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RETRACTED ARTICLE: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats

Cited by 9 publications

References 50 publications

Myrtenal improves memory deficits in mice exposed to radiofrequency-electromagnetic radiation during gestational and neonatal development via enhancing oxido-inflammatory, and neurotransmitter functions

Myrtenal improves memory deficits in mice exposed to radiofrequency-electromagnetic radiation during gestational and neonatal development via enhancing oxido-inflammatory, and neurotransmitter functions

"Analisis Senyawa Flavonoid pada Jeruk Manis (Citrus sinensis L.) sebagai Pengobatan Wasir"

Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model

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