RETRACTED ARTICLE: HAX-1 Promotes the Chemoresistance, Invasion, and Tumorigenicity of Esophageal Squamous Carcinoma Cells

Sun, Sa-Jia; Lin, Feng; Zhao, Guoqiang; Dong, Ziming

doi:10.1007/s10620-012-2108-5

Cited by 22 publications

(15 citation statements)

References 27 publications

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“…The inhibition was more acutely observed when invasive migration of SKOV3 cells in which Hax-1 was silenced was monitored using collagen I coated TransWell invasion assay. Although a role for Hax-1 in metastasis has been speculated based on its expression profile in metastatic cells [13, 14, 17, 20], the results presented here provide the first evidence that Hax-1 is critically required for the invasive migration of an ovarian carcinoma cell line in response to both LPA and serum growth factors. In light of the findings that LPA plays a dominant role in ovarian cancer cell migration, the observation that LPA-stimulated migration requires Hax-1 is quite significant.…”

Section: Discussionmentioning

confidence: 70%

“…Recently, it has also been observed that the homozygous mutations in Hax-1 gene or loss of Hax-1 are associated with severe congenital neutropenia and neurodevelopmental disorders. In addition, overexpression of Hax-1 has been observed in tissues from esophageal, lung and colon cancers [13, 14, 17, 20]. More significantly, in colorectal cancer the increased expression of Hax-1 correlates with the lymph node metastasis and poor prognosis of the patients[13].…”

Section: Discussionmentioning

confidence: 99%

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Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration

Gomathinayagam

Jayaraman

et al. 2014

Genes Cancer

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration

Gomathinayagam

Jayaraman

et al. 2014

Genes Cancer

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“…Previous studies of our team found that HAX-1 promotes the proliferation, chemo-resistance, invasion, and tumorigenicity of ESCC, and this is correlated with increased DNA polymerase β expression. HAX-1 may represent a potential target to overcome the resistance and metastasis of ESCC [23]. …”

Section: Discussionmentioning

confidence: 99%

Analysis of HAX-1 gene expression in esophageal squamous cell carcinoma

Tang

Zang

et al. 2013

Diagn Pathol

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ObjectiveTo explore the expression of HAX-1 mRNA and protein in esophageal squamous cell carcinoma (ESCC) and its relation with the prognosis of patients with ESCC.MethodsThe expression of HAX-1 mRNA and protein were detected with quantitative real-time RT-PCR and immunohistochemical method in 112 ESCC samples and 112 corresponding non-neoplastic samples. Survival curves were made with follow-up data. The relations of the prognosis with clinical and pathological characteristics were analyzed.ResultsThe expression level of HAX-1 mRNA and the strong positive rate of HAX-1 protein were significantly higher in ESCC samples (0.527 ± 0.060 and 45.54%) than that in non-neoplastic samples (0.121 ± 0.017 and 0.00%), and in ESCC samples with lymph node metastasis (0.554 ± 0.054 and 71.11%) than that in ESCC samples without lymph node metastasis (0.509 ± 0.058 and 28.36%) (all P < 0.01). HAX-1 mRNA expression level was a risk factor of lymph node metastasis in patients with ESCC (P = 0.000). There were significant differences in survival curves between lymph node metastatic group and non-metastatic group (P = 0.000), and among groups of HAX-1 protein expression +, ++and +++(,P = 0.000); but no statistical significance between male patients and female patients (P = 0.119), and between ≥60 years old patients and <60 years old patients (P = 0.705). The level of HAX-1 mRNA (P = 0.000) and protein (P = 0.005) were risk factors of survival, but lymph node metastasis (P = 0.477) was not.ConclusionThere is HAX-1 over-expression in ESCC tissue and HAX-1 mRNA level is a risk factor of lymph node metastasis. The level of HAX-1 mRNA and protein were risk factors of survival in patients with ESCC. HAX-1 may be a novel therapeutic target for ESCC treatment.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5130393079296037

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“…e typical pathological hallmarks of ESCC cells, like most malignant tumor cells, are invasion, metastasis, and resistance to apoptosis [39][40][41]. Our study showed that germacrone treatment inhibited the migration of Eca109 and EC9706 cells even at a low concentration and inhibited the expression of matrix metalloproteinase dose-dependently, suggesting that germacrone can inhibit the invasion and migration of ESCC cells.…”

Section: Discussionmentioning

confidence: 57%

Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells

Zhang

Jiang

Guo

et al. 2020

BioMed Research International

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Germacrone, a natural 10-membered monocyclic sesquiterpene with three double bonds and a ketone, was isolated from the roots of traditional Chinese medicine Saussurea costus (SC). The pharmacological value and intrinsic mechanism of germacrone in the treatment of esophageal squamous cell carcinoma (ESCC) are still unclear. Therefore, in this study, we further explored the internal molecular mechanism by which germacrone exerts its antiproliferation and antimigration ability against ESCC. 3-(4,5-Dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assays showed that germacrone dose-dependently inhibited the proliferation of ESCC cells. Flow cytometry analysis (FACS) and wound healing experiments on germacrone treated ESCC cells showed that germacrone could induce apoptosis and inhibit the migration of ESCC cells in a dose-dependent manner. In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7. In addition, we found that germacrone also inhibited STAT3 phosphorylation in a dose-dependent manner. In conclusion, we determined that germacrone exerted an antiesophageal effect through intrinsic apoptotic signaling pathways and by inhibiting STAT3 activity in ESCC cells.

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RETRACTED ARTICLE: HAX-1 Promotes the Chemoresistance, Invasion, and Tumorigenicity of Esophageal Squamous Carcinoma Cells

Abstract: HAX-1 promotes the proliferation, chemoresistance, invasion, and tumorigenicity of ESCC, and this is correlated with increased poly β expression. HAX-1 may represent a potential target to overcome the resistance and metastasis of ESCC.

Cited by 22 publications

References 27 publications

Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration

Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration

Analysis of HAX-1 gene expression in esophageal squamous cell carcinoma

Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells

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