RETRACTED ARTICLE: Human microbiome and homeostasis: insights into the key role of prebiotics, probiotics, and symbiotics

Salehi, Bahare; Dimitrijević, Marina; Aleksić, Ana; Neffe‐Skocińska, Katarzyna; Zielińska, Dorota; Kołożyn-Krajewska, Danuta; Sharifi‐Rad, Javad; Stojanović-Radić, Zorica; Prabu, S. Milton; Rodrigues, Célia Fortuna; Martins, Natália

doi:10.1080/10408398.2020.1760202

Cited by 25 publications

(25 citation statements)

References 162 publications

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“…Numerous clinical and scientific studies instill a promising window, considering that the gastrointestinal (GI) tract has a fundamental role to enhance the host immunity of COVID-19 [ 149 , 165 ]. In this regard, (normal) microbiota are described as the population of microorganisms (e.g., fungi, virus, bacteria) which particularly exist in the gut, with beneficial activity for the host (e.g., production of vitamins, facilitation of digestion, and stimulation of immune response against pathogens) [ 1 , 166 , 167 , 168 ]. Therefore, physiological changes in the intestinal tract easily lead to infection and inflammation disorders.…”

Section: Role Of the Microbiome And Probiotics To Fight Covid-19mentioning

confidence: 99%

“…As microbiota can affect antiviral immunity, probiotics are indicated as having anti-viral, anti-inflammatory, and anti-allergic activities, and to decrease the time duration and rate of respiratory viral infections [ 167 , 168 , 179 , 180 ]. Commensal fungi are well-known mycobiota, which directly and indirectly impact virus pathogenesis in the lungs [ 173 ].…”

Section: Role Of the Microbiome And Probiotics To Fight Covid-19mentioning

confidence: 99%

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Overview on the Prevalence of Fungal Infections, Immune Response, and Microbiome Role in COVID-19 Patients

Roudbary

Kumar

et al. 2021

JoF

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Patients with severe COVID-19, such as individuals in intensive care units (ICU), are exceptionally susceptible to bacterial and fungal infections. The most prevalent fungal infections are aspergillosis and candidemia. Nonetheless, other fungal species (for instance, Histoplasma spp., Rhizopus spp., Mucor spp., Cryptococcus spp.) have recently been increasingly linked to opportunistic fungal diseases in COVID-19 patients. These fungal co-infections are described with rising incidence, severe illness, and death that is associated with host immune response. Awareness of the high risks of the occurrence of fungal co-infections is crucial to downgrade any arrear in diagnosis and treatment to support the prevention of severe illness and death directly related to these infections. This review analyses the fungal infections, treatments, outcome, and immune response, considering the possible role of the microbiome in these patients. The search was performed in Medline (PubMed), using the words “fungal infections COVID-19”, between 2020–2021.

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Section: Role Of the Microbiome And Probiotics To Fight Covid-19mentioning

confidence: 99%

Section: Role Of the Microbiome And Probiotics To Fight Covid-19mentioning

confidence: 99%

Overview on the Prevalence of Fungal Infections, Immune Response, and Microbiome Role in COVID-19 Patients

Roudbary

Kumar

et al. 2021

JoF

View full text Add to dashboard Cite

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“… 6 – 8 In addition, and namely to what concerns to the use of probiotics, they have emerged as a promising and safe therapy in for different purposes in clinical practice. 7 , 8 However, such effectiveness depends on the species and doses used, as well as on underlying disease, with duration of administration also impacting the final outcomes, these ones also varying according to the clinical indication. 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

“… 7 , 8 However, such effectiveness depends on the species and doses used, as well as on underlying disease, with duration of administration also impacting the final outcomes, these ones also varying according to the clinical indication. 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

Obesity and gut microbiome: review of potential role of probiotics

Schütz¹,

Figueiredo-Braga

Barata

et al. 2021

Porto Biomedical Journal

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Obesity prevalence has increased worldwide over the years, with pandemic levels being already reached, besides to its huge economic and health impacts. The multifactorial pathogenesis of obesity partly explains the important challenge posed to health policy regarding its clinical treatment, with increasing evidences have shown that obesity and metabolic disturbances are closely linked to variations in gut microbiota (GM) function and composition. Indeed, GM play a key contribution in energy metabolism, with GM modulation being increasingly linked to changes in body weight and body mass index. In such matter, probiotics have been proposed as a promising new therapeutic strategy to treat/prevent obesity. Thus, this review aims to provide an overview on the clinical impact and effectiveness of probiotics in obese individuals.

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“…Gut microbiota may also play a role in how drugs are metabolized in our body [11]. These commensal bacteria play important roles as key regulators of digestion, involving the extraction, synthesis, and absorption of many nutrients and metabolites, including bile acids, lipids, amino acids, vitamins, and short-chain fatty acids (SCFAs) [11]. The gut microbiota also have a crucial immune function against pathogenic bacteria colonization through many competition processes [12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Polyphenols in Tea (Camellia sinensis sp.) on the Modulation of Gut Microbiota in Human Trials and Animal Studies

Khairudin

Jalil

Hussin

2021

Gastroenterology Insights

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A diet high in polyphenols is associated with a diversified gut microbiome. Tea is the second most consumed beverage in the world, after water. The health benefits of tea might be attributed to the presence of polyphenol compounds such as flavonoids (e.g., catechins and epicatechins), theaflavins, and tannins. Although many studies have been conducted on tea, little is known of its effects on the trillions of gut microbiota. Hence, this review aimed to systematically study the effect of tea polyphenols on the stimulation or suppression of gut microbiota in humans and animals. It was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. Articles were retrieved from PubMed and Scopus databases, and data were extracted from 6 human trials and 15 animal studies. Overall, large variations were observed in terms of microbiota composition between humans and animals. A more consistent pattern of diversified microbiota was observed in animal studies. Tea alleviated the gut microbiota imbalance caused by high-fat diet-induced obesity, diabetes, and ultraviolet-induced damage. The overall changes in microbiota composition measured by beta diversity analysis showed that tea had shifted the microbiota from the pattern seen in animals that received tea-free intervention. In humans, a prebiotic-like effect was observed toward the gut microbiota, but these results appeared in lower-quality studies. The beta diversity in human microbiota remains intact despite tea intervention; supplementation with different teas affects different types of bacterial taxa in the gut. These studies suggest that tea polyphenols may have a prebiotic effect in disease-induced animals and in a limited number of human interventions. Further intervention is needed to identify the mechanisms of action underlying the effects of tea on gut microbiota.

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RETRACTED ARTICLE: Human microbiome and homeostasis: insights into the key role of prebiotics, probiotics, and symbiotics

Cited by 25 publications

References 162 publications

Overview on the Prevalence of Fungal Infections, Immune Response, and Microbiome Role in COVID-19 Patients

Overview on the Prevalence of Fungal Infections, Immune Response, and Microbiome Role in COVID-19 Patients

Obesity and gut microbiome: review of potential role of probiotics

Effects of Polyphenols in Tea (Camellia sinensis sp.) on the Modulation of Gut Microbiota in Human Trials and Animal Studies

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