With the development of VR and Internet of things and the characteristics of isomorphic block decoration, based on the two technologies, this paper comes to the realization of isomorphic block decoration in fashion design. Firstly, by analyzing the algorithm combining VR and the Internet of things, a platform based on the combination of both technologies is established. Then, the platform is applied to the same shape block decoration in different cities in the process of fashion design, and the differences in the process of fashion design are analyzed. The results of fashion design show that the isomorphic block decoration based on the combination of VR and Internet of things should be designed according to the local characteristics to promote the development of fashion design industry according to local conditions. In general, this paper provides some theoretical and practical experience for the application of isomorphic block decoration in fashion design.