RETRACTED ARTICLE: Interactions of Aspergillus fumigatus with the respiratory system in poultry

Munir, Muhammad; Rehman, Zaib Ur; Shah, M.A.A.; Umar, Sajid

doi:10.1017/s0043933917000022

Cited by 13 publications

(19 citation statements)

References 38 publications

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“…Aspergillosis can occur as an acute disease with high morbidity and mortality in young birds, or it can occur as a chronic disease, affecting fewer numbers of older birds (2). Clinical signs such as dyspnea, gasping and hyperpnea are usually associated with aspergillosis (8).…”

Section: Discussionmentioning

confidence: 99%

“…infectious bronchitis, respiratory manifestation (gasping), laryngotracheitis, and fowl pox (1,7). It has been speculated that extremely dry air and dust can cause the infection with Aspergillus because they dry out the respiratory mucosa and the protective effect of mucus is reduced (8).…”

Section: Introductionmentioning

confidence: 99%

“…Cutaneous, respiratory, ocular and nervous signs forms of aspergillosis have been reported worldwide (8)(9)(10)(11). These organisms have the ability to penetrate egg shells, and the newly hatched chicks may become infected (10) and this is commonly termed as hatchery borne infection (6).…”

Section: Introductionmentioning

confidence: 99%

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Case Report: Prevalence and significance of aspergellosis in commercial broiler chicken: Pathological study

Eassa¹,

Mohammed²,

Omer³

2017

IJVS

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The present study was carried out to evaluate the pathological effects of aspergillosis caused by Aspergillus Spp. in commercial broiler chickens. In this study, we discussed few outbreaks of Aspergillus infection of chicks a week aftter hatching in broiler farms of Duhok-Kurdistan region of Iraq during the period from February to May 2015 on the basis of clinical signs, post-mortem, histopathological and cultural findings. The main clinical signs of the disease in the infected flock included a 3-day onset of labored breathing and neurologic disorders displayed by incoordination, torticollis, and paralysis. Other clinical features included depression, ruffled feathers and gasping. Gross lesions were represented by cheesy granular materials in the air sacs, lungs, and trachea. Histopathology revealed fungal hyphae in sectioned lung tissue. Aspergillus was isolated by culturing in Sabouraud's dextrose agar from the lesions. The present study deals with the incidence of acute aspergillosis in broiler chicks from Duhok, Kurdistan-Iraq.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Case Report: Prevalence and significance of aspergellosis in commercial broiler chicken: Pathological study

Eassa¹,

Mohammed²,

Omer³

2017

IJVS

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“…Aspergillus fumigatus, mainly present in mildewed feedstuff and contaminating ambiant air, is an opportunistic pathogen for poultry inducing respiratory diseases and immunosuppression. The conidia (2.0-3.0 µm in diameter) are easily inhaled and deposited in the lower respiratory tract (33). In the current study, right thoracic intra-air sacs injection was adopted as the inoculation route to infect the 14-days-old SPF White Leghorn chickens with A. fumigatus conidia (2 × 10 6 CFU per chicken).…”

Section: Discussionmentioning

confidence: 99%

Pathogenicity and Immune Responses of Aspergillus fumigatus Infection in Chickens

Cheng

Wang

et al. 2020

Front. Vet. Sci.

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Aspergillus fumigatus is a ubiquitous pathogen in poultry farms, causing aspergillosis in chickens. To study the pathogenicity of A. fumigatus, 14-days-old chickens were infected with fungal conidia (2 × 10 7 CFU/mL) via thoracic intra-air sacs inoculation. The clinical symptoms, gross and histopathological lesions, and fungal load in the lungs were examined. Additionally, the mRNAs of Toll like receptors (TLR) and pro-inflammatory cytokines were evaluated by quantitative PCR to explore the immune responses induced by A. fumigatus. The results showed that overt depression, ruffled feathers, and dyspnea were observed in the infected chickens as early as 3 days post infection (dpi). Eleven out of 25 infected chickens died from 5 to 9 dpi, and A. fumigatus could also be reisolated from the infected lung. Histopathological examination revealed obvious airsacculitis and pneumonia, characterized by inflammatory cell infiltration (heterophils and macrophages), and granulomatous lesions in the lung. The mRNA expressions of TLR1 and TLR2 were upregulated in the lung and spleen, and most pro-inflammatory cytokines including IL-1β, Cxcl-8, TNF-α, IL-12, and IFN-γ were increased in both the lung and spleen during the tested period, suggesting that the innate immune responses were triggered by A. fumigatus infection, and these cytokines participated in the inflammatory responses against A. fumigatus. These results indicate that A. fumigatus infection by thoracic intra-air sacs inoculation can cause severe respiratory damage in chickens, activate TLR1 and TLR2 mediated immune responses, and elicit large expression of pro-inflammatory cytokines such as IL-1β, Cxcl-8, and IFN-γ. These data will help further understanding of the pathogenesis and immune responses of A. fumigatus infection in the chicken.

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“…En general en el aire, predominan los géneros Cladosporium, Penicillium, Aspergillus, Alternaria y las levaduras (Araujo & Cabral 2010 (Bondy & Pestka 2000). Sin embargo, existe también el riesgo profesional de contaminación por inhalación de conidios en el aire o en materiales fácilmente volátiles dentro de lugares de trabajo donde haya riesgo de exposición (Munir et al 2017). La aparición de estos hongos en el ambiente de cría de aves, genera un problema de contaminación tanto para las aves de consumo como para los operarios del galpón.…”

Section: Introductionunclassified

Desarrollo de una mezcla microbiana para la inclusión como probiótico en la industria avícola: estudio de su acción sobre hongos contaminantes y micotoxinas

Franco¹

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Se evaluó la potencialidad probiótica de un grupo de microorganismos obtenidos del kefir en pollos parrilleros. El kefir es un producto ancestral y natural con comprobada acción probiótica en humanos. Para este fin se planteó el uso de permeado de suero como sustrato de fermentación de los microorganismos seleccionados. Previo a los ensayos in vivo se realizaron estudios in vitro de los microorganismos seleccionados y el permeado de suero fermentado con los mismos. Se analizó la capacidad antifúngica, tanto de los microorganismos como de permeado de suero (PS) fermentado por éstos, contra hongos aislados en distintas etapas la cría de pollos parrilleros. Se probó la capacidad de los microorganismos estudiados en la protección de una línea celular, frente a la acción tóxica de la aflatoxina B1. Para finalizar los ensayos in vitro se comprobó la capacidad de los microorganismos de capturar AFB1 en diferentes concentraciones. Una vez probados todos los desafíos in vitro, tanto el PS fermentado como las cepas se suministraron a pollos parrilleros, comprobando que tienen efectos benéficos y son cepas inocuas para las aves.

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RETRACTED ARTICLE: Interactions of Aspergillus fumigatus with the respiratory system in poultry

Cited by 13 publications

References 38 publications

Case Report: Prevalence and significance of aspergellosis in commercial broiler chicken: Pathological study

Case Report: Prevalence and significance of aspergellosis in commercial broiler chicken: Pathological study

Pathogenicity and Immune Responses of Aspergillus fumigatus Infection in Chickens

Desarrollo de una mezcla microbiana para la inclusión como probiótico en la industria avícola: estudio de su acción sobre hongos contaminantes y micotoxinas

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