RETRACTED ARTICLE: Lactoferrin versus ferrous sulphate for the treatment of iron deficiency anemia during pregnancy: a randomized clinical trial

Rezk, Mohamed; Dawood, Ragab; Abo-Elnasr, Mohamed; Halaby, Alaa Al; Marawan, Hala

doi:10.3109/14767058.2015.1049149

Cited by 28 publications

(26 citation statements)

References 11 publications

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“…However, after one month of treatment, both groups showed significant increase of hemoglobin with significant increase in lactoferrin group. This agreed with the study of Rezk et al [11] that stated that mean increase of hemoglobin level was by (2.26 ±.51 g/dl) in patients with IDA who received Lf for 8 weeks on a dose of 250 mg once daily. Another study by Paesano et al [9] revealed that mean increase of hemoglobin level was (1.7 ± 0.9 g/dl) in patients with IDA who received Lf for 30 days on a dose of 100 mg twice daily.…”

Section: Discussionsupporting

confidence: 92%

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Effect of Lactoferrin Supplementation on Iron Deficiency Anemia in Primary School Children

El-Khawaga

Abdelmaksoud

2019

International Journal of Medical Arts

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Section: Discussionsupporting

confidence: 92%

“…Mean TIBC before treatment was 3.9 and after one month, it decreases to 3.1 in Lf group compared to, 3.8 before and 3.2 after treatment in elemental iron group. This agreed with the study of Rezk et al [11] that stated that of TIBC levels decreased in cases with IDA who received Lf for 8 weeks on a dose of 250 mg once daily.…”

Section: Discussionsupporting

confidence: 92%

Effect of Lactoferrin Supplementation on Iron Deficiency Anemia in Primary School Children

El-Khawaga

Abdelmaksoud

2019

International Journal of Medical Arts

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“…In particular, lactoferrin is a safer alternative for adult women, including pregnant women who are contraindicated for teratogenic acne medications. Several studies have shown lactoferrin to be safe for pregnant women in different gestational stages . Thus, further studies in these specific patient populations are warranted.…”

Section: Discussionmentioning

confidence: 99%

A randomized, double‐blind, placebo‐controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris

Chan¹,

Chan²,

Santos³

et al. 2017

Int J Dermatology

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Lactoferrin is an iron-binding milk-derived protein that has shown antibacterial and anti-inflammatory effects in vitro and in vivo. The objective of this study was to determine the efficacy and safety of lactoferrin, combined with vitamin E and zinc, for mild to moderate acne vulgaris. In this randomized, double-blind, placebo-controlled trial, 168 subjects aged 13-40 years old were randomly assigned to take either a capsule formulation containing lactoferrin with vitamin E and zinc or placebo twice a day for 3 months. The primary outcome measure was a reduction in the number of acne lesions compared to placebo. A total of 164 subjects completed the study per protocol. The lactoferrin group (n = 82) showed a significant median percent reduction in total lesions as early as 2 weeks (14.5%, P = 0.0120), with the maximum reduction occurring at week 10 (28.5%, P < 0.0001) compared to placebo group (n = 82). Maximum reduction in comedones (32.5%, P < 0.0001) and inflammatory lesions (44%, P < 0.0001) was also seen at week 10 compared to placebo. Sebum scores were improved by week 12. No adverse events were observed during the trial. A twice daily regimen of lactoferrin with vitamin E and zinc significantly reduced acne lesions in people with mild to moderate acne vulgaris.

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“…This study confirmed that the feasibility of LF in the treatment of the inflammatory response to acne, but further studies are needed to determine the adverse effects and the optimal therapeutic dose. Especially, compared to teratogenic acne medication, lactoferrin is safe for adult women, including pregnant women, several studies 16 17 have shown that lactoferrin on different stages of pregnancy is safe, therefore, it is necessary to further research the pregnancy patients with moderately severe acne patients, as well having the desire to cure. Moreover, our study has limitation is that if we had checked gene expression profile through more advanced methods, such as, RNA sequencing method, we could achieve more accurate results, so we hope more researchers to plan for the great projects for achieving high throughput findings.…”

Section: Discussionmentioning

confidence: 99%

Influence of lactoferrin on Propionibacterium acnes ‐induced inflammation in vitro and in vivo

Cui

Wei

2020

Dermatologic Therapy

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Lactoferrin (LF) is a monomer glycoprotein in the mammalian colostrum that has multiple biological activities and a high affinity for iron ions. Not only does it have strong antibacterial activity, it also can regulate the release of cytokines in inflammatory areas, activate immune cells, and inhibit inflammatory diseases caused by nonpathogenic bacteria and the development of tumors. However, the anti-inflammatory mechanism of LF in inflammatory skin diseases induced by Propionibacterium acnes (P. acnes) has not been elucidated in vitro and in vivo. In this study, we investigated the effects of LF on the generation of inflammatory cytokines in HaCaT cells induced by heat-killed P. acnes. The expression of pro-inflammatory cytokines IL-8 increased after induction of HaCaT by heat-killed P. acnes, but it decreased significantly after LF treatment. Western blotting was used to examine the levels of TLR2, nuclear factor (NF) κB and intercellular cell adhesion molecule 1 protein induced by P. acnes in HaCaT cells, and the results showed that the levels were inhibited by LF. In addition, activated P. acnes (1 × 107 CFU/mL) was injected into the ears of experimental mice, which induced inflammation 24 hours after the injection. However, immunohistochemical analysis showed a significant reduction in the inflammatory response after LF treatment in the right ear relative to the untreated left ear, and the same result was seen with western blotting. In summary, this study revealed the treatment effect of LF on P. acnes-induced inflammation, thus providing support for the anti-acne properties of LF.

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RETRACTED ARTICLE: Lactoferrin versus ferrous sulphate for the treatment of iron deficiency anemia during pregnancy: a randomized clinical trial

Abstract: Lactoferrin was more effective than ferrous sulfate over a two-month period in pregnant women with IDA, with fewer gastrointestinal adverse events and better treatment acceptability.

Cited by 28 publications

References 11 publications

Effect of Lactoferrin Supplementation on Iron Deficiency Anemia in Primary School Children

Effect of Lactoferrin Supplementation on Iron Deficiency Anemia in Primary School Children

A randomized, double‐blind, placebo‐controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris

Influence of lactoferrin on Propionibacterium acnes ‐induced inflammation in vitro and in vivo

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