RETRACTED ARTICLE: LncRNA LINC00152 promoted glioblastoma progression through targeting the miR-107 expression

Abstract

Long non-coding RNAs (lncRNAs) LINC00152 plays important roles in the progression of some tumors. However, the role of LINC00152 in human l glioblastoma is still unknown. In this study, we indicated that LINC00152 expression level was upregulated in glioblastoma tissues and cell lines. Overexpression of LINC00152 promoted the U87 and LN229 cell proliferation and invasion. Moreover, overexpression of LINC00152 suppressed the E-cadherin expression, where ectopic expression of LINC00152 promoted the N-cadherin, Vimentin, and Snail expression. These results suggested that LINC00152 enhanced epithelial-to-mesenchymal transition (EMT) program in the glioblastoma cell. Overexpression of LINC00152 suppressed the miR-107 expression in the U87 cell and enhanced the HMGA2 expression, which is a direct target gene of miR-107. In addition, we showed that the miR-107 expression was downregulated in the glioblastoma tissues and cell lines. Interesting, the expression of LINC00152 was negatively related with miR-107 expression in the glioblastoma tissues. Furthermore, LINC00152 promoted the glioblastoma cell proliferation and invasion through inhibiting miR-107 expression. These data suggested that LINC00152 acted as oncogene roles in the glioblastoma cell partly through targeting the miR-107 expression.

MATN1‐AS1 promotes glioma progression by functioning as ceRNA of miR‐200b/c/429 to regulate CHD1 expression

“…All these reports indicated that there are interactions between miRNAs, lncRNAs and mRNAs in tumours. What's more, it is also elucidated that lncRNAs would influence the progression by sponging miRNAs even in glioma . Herein, we confirmed the interaction between MATN1‐AS1 and miR‐200b/c/429 as well as their negative correlations in glioma tissues.…”

Role of LINC00152 in non-small cell lung cancer

“…It serves as an independent risk factor for disease-free survival (DFS) and overall survival (OS) (Zhang PP et al, 2017). Yu MJ et al, 2017;Cai et al, 2018;Chen X et al, 2018;Liu et al, 2018;Reon et al, 2018;Zhu et al, 2018 Chen et al, 2017;Feng et al, 2017;Li et al, 2017;Ma et al, 2017;Nötzold et al, 2017;Xu et al, 2017;Zhang PP et al, 2017;Reon et al, 2018;Zhang and Li, 2018;Zhao et al, 2018;Liu ZZ et al, 2019 Colon cancer ↑ ↓ Qiu and Yan, 2015;Bian et al, 2017;Nishizawa et al, 2018;Wang X et al, 2018;Yue et al, 2018Zhang et al, 2016 This conclusion has been also confirmed by other reports (Feng et al, 2017;Reon et al, 2018) on the Gene Expression Omnibus (GEO) (Seo et al, 2012) and The Cancer Genome Atlas (TCGA) databases (Collisson et al, 2014). Zhao et al (2018) analyzed the expression profiles of lncRNAs in three pairs of lung adenocarcinoma tissues and adjacent normal tissues.…”

Long Intervening Noncoding 00467 RNA Contributes to Tumorigenesis by Acting as a Competing Endogenous RNA against miR-107 in Cervical Cancer Cells

“…12 In addition, another lncRNA, LINC00152, was previously demonstrated to promote glioblastoma progression by targeting miR-107. 28 Similarly, Gius et al 29 showed that KIF23 was overexpressed in normal cervical epithelium obtained from cervical cancer patients. Consistent with our findings, another recent study predicted that KIF23 was a target gene of miR-195.…”