RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

Abstract

In relieving local pains, lidocaine, one of ester-type local anesthetics, has been used. To develop the lidocaine membranes of enhanced local anesthetic effects, we have designed to establish the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded chitosan (CS)/ polymyxin B sulfate (PMB). The LCH membranes (LCH-CS/PMB) was fabricated by the LCH oxide solutions within the CS/PMB matrix. The influences of different experimental limitations on CS/PMB membrane formations were examined. The double membrane particle sizes were evaluated by scanning electron microscopy (HR-SEM). Additionally, antibacterial efficacy was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 16 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH-CS/ PMB-treated wound with less damaging. These findings indicate that LCH-CS/PMB-based bandaging materials could be a potential innovative biomaterial for tissue repair and regeneration for wound healing applications in an animal model.

Development of Nanogel Loaded with Lidocaine for Wound-Healing: Illustration of Improved Drug Deposition and Skin Safety Analysis

“…It is reported to be one of the primary reasons for the loss of skin defence functions. According to WHO, the postoperative wound is a major contributor to mortality [ 2 ]. Wounds are considered a major confounding factor for patients’ poor quality of life and lay down an enormous burden on socio-economic balance.…”

Physiology of pregnancy and oral local anesthesia considerations

“…Topical anesthesia offers the possibility of painless dental anesthesia, but there are currently no commercially available formulations that eliminate the pain of local anesthesia injections ( Hindocha et al, 2019 ). In order to enhance the permeability of lidocaine and improve the effectiveness of surface anesthesia, some materials, such as liposomes ( Franz-Montan et al, 2015 ; Ribeiro et al, 2016 ), silica nanoparticles ( Nafisi et al, 2018 ; Sato et al, 2019 ), and chitosan ( Qi et al, 2021 ), have been gradually developed as lidocaine delivery systems. However, most lidocaine delivery systems focus on the transdermal route.…”

Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing

“…Antibacterial chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats and alginate/silver/nicotinamide nanocomposites are developed to treat diabetic wounds (Montaser et al., 2016 ; Ahmed et al., 2018 ). During the past several decades, electrospinning is fast developing from a single-fluid blending process (Abd El Hady et al., 2021 ; Qi et al., 2021 ), to coaxial (Ning et al., 2021 ; Liu et al., 2022 ), triaxial (Liu et al., 2014 ), side-by-side (Wang et al., 2022 ), tri-layer side-by-side (Jiang et al., 2022a ), and other complicated processes (Du et al., 2022 ), which greatly expand its capability of creating nanocomposites. However, nanocomposites often contain one drug for a designed drug-controlled release profile (Jaragh-Alhadad et al., 2022 ; Zhang et al., 2022 ).…”