RETRACTED ARTICLE: Long non-coding RNA TPT1-AS1 promotes cell growth and metastasis in cervical cancer via acting AS a sponge for miR-324-5p

Jiang, Hui; Huang, Guofu; Zhao, Nianzhang; Zhang, Ting; Jiang, Mengni; He, Yinghui; Zhou, Xinke; Jiang, Xianhan

doi:10.1186/s13046-018-0846-8

Cited by 72 publications

(73 citation statements)

References 36 publications

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“…In our study, TPT1‐AS1 was proved to promote EOC tumor growth and metastasis through TPT1 and the downstream PI3K/AKT signaling pathway. In cervical cancers, TPT1‐AS1 was verified to facilitate cell proliferation, migration and invasion via sponge for miR‐324‐5p . However, in glioblastoma, TPT1‐AS1 was demonstrated to be a protective lncRNA, and to be highly expressed in a low risk group, through binding with inhibitory targets, including AGO2, CPSF7, ELAVL1 and FUS, predicted by CLIP‐seq data.…”

Section: Discussionmentioning

confidence: 96%

“…In cervical cancers, TPT1-AS1 was verified to facilitate cell proliferation, migration and invasion via sponge for miR-324-5p. 11 However, in glioblastoma, TPT1-AS1 was demonstrated to be a protective lncRNA, and to be highly expressed in a low risk group, through binding with inhibitory targets, including AGO2, CPSF7, ELAVL1 and FUS, predicted by CLIP-seq data. 10 The reason lncRNA plays opposite functions in different tumor cells may be due to the different targets it is binding to.…”

Section: Discussionmentioning

confidence: 98%

“…Studies have confirmed that lncRNA tumor protein translationally controlled 1 (TPT1) antisense RNA 1 (TPT1‐AS1) functions as a protective lncRNA in glioblastoma . In contrast, TPT1‐AS1 has been demonstrated to promote cell growth and metastasis by acting as a ceRNA for miR‐324‐5p in cervical cancers . However, the roles and mechanisms of TPT1‐AS1 in EOC tumorigenesis and progression remain to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

“…10 In contrast, TPT1-AS1 has been demonstrated to promote cell growth and metastasis by acting as a ceRNA for miR-324-5p in cervical cancers. 11 However, the roles and mechanisms of TPT1-AS1 in EOC tumorigenesis and progression remain to be elucidated. In this study, the expression of TPT1-AS1 in EOC tissue and cells and the association between TPT1-AS1 and EOC clinicopathological features were investigated.…”

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confidence: 99%

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LncRNA TPT1‐AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression

Wei

Gao

et al. 2019

Cancer Science

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Increasing numbers of studies have confirmed that long noncoding RNA (lnc RNA ) play a critical role in epithelial ovarian cancer ( EOC ) progression. However, the potential function of the lnc RNA tumor protein translationally controlled 1 ( TPT 1) antisense RNA 1 ( TPT 1‐ AS 1) in EOC is unclear. In this study, we aimed to uncover the biological roles and regulatory mechanisms of TPT 1‐ AS 1 in EOC progression and metastasis. First, TPT 1‐ AS 1 expression was significantly higher in EOC metastatic tissue and cell lines than in their respective control counterparts. In addition, ectopic TPT 1‐ AS 1 expression was strongly associated with unfavorable EOC clinicopathological features, including FIGO stage, tumor size and tumor differentiation. TPT 1‐ AS 1 overexpression remarkably induced cell proliferation, migration and invasion, and significantly attenuated cell adhesion ability in vitro and facilitated nude mouse subcutaneous xenograft growth and intraperitoneal metastasis in vivo, while the downregulation of TPT 1‐ AS 1 expression produced the opposite effect in vitro. Mechanistically, TPT 1‐ AS 1 was proven to be primarily distributed in EOC cell nuclei and positively modulated TPT 1 promoter activity and transcription. Moreover, the oncogenic effects of TPT 1‐ AS 1 could be reversed by TPT 1 depletion, and the PI 3K/ AKT signaling pathway downstream of TPT 1 was also altered. These results suggested that TPT 1‐ AS 1 induced EOC tumor growth and metastasis through TPT 1 and downstream PI 3K/ AKT signaling and that TPT 1‐ AS 1 may be a promising therapeutic target for EOC .

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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LncRNA TPT1‐AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression

Wei

Gao

et al. 2019

Cancer Science

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“…8 For example, lncRNA SBF2 antisense RNA 1 (SBF2-AS1) promoted the progression of cervical cancer by regulating miR-361-5p/FOXM1 axis; 18 lncRNA TPT1 antisense RNA 1 (TPT1-AS1) facilitated cell growth and metastasis in cervical cancer by functioning as an endogenous sponge for miR-324-5p. 19 The cytoplasm is the main location for ceRNA action. 20 TMPO-AS1 was predominantly localized in the cytoplasm in PCa cells, 5 indicating the post-transcriptional regulation of TMPO-AS1.…”

Section: Discussionmentioning

confidence: 99%

<p>Long Non-Coding RNA TMPO-AS1 Promotes Cervical Cancer Cell Proliferation, Migration, and Invasion by Regulating miR-143-3p/ZEB1 Axis</p>

Gang¹,

Yuan²,

Zhang³

2020

CMAR

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Objective: Long non-coding RNAs (lncRNAs) have been identified as important players in tumorigenesis. LncRNA TMPO antisense RNA 1 (TMPO-AS1) has been shown to be involved in several tumors. However, the functional role and the underlying mechanism of TMPO-AS1 in regulating cervical cancer cell behavior remain unclear. Materials and Methods: Expression of TMPO-AS1, miR-143-3p, and ZEB1 were examined by qRT-PCR and Western blot. Cell proliferation, migration and invasion were evaluated using CCK-8 assay and Transwell migration and invasion assays, respectively. Luciferase reporter assay was performed to investigate the interaction miR-143-3p and TMPO-AS1 or ZEB1. Results: TMPO-AS1 was highly expressed in cervical cancer cells. Furthermore, TMPO-AS1 overexpression significantly promoted C-33A cell proliferation, migration, and invasion. In contrast, TMPO-AS1 silencing inhibited SiHa cell proliferation, migration, and invasion. Mechanistically, TMPO-AS1 acted as a sponge of miR-143-3p to elevate expression of zinc finger E-box binding homeobox 1 (ZEB1), a target of miR-143-3p, and thereby promoted C-33A cell proliferation, migration, and invasion. Further assays showed that TMPO-AS1 knockdown inhibited cervical cancer cell tumorigenesis in vivo. Conclusion: TMPO-AS1 promotes cervical cancer cell proliferation, migration, and invasion by regulating the miR-143-3p/ZEB1 axis.

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Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma

et al. 2020

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Background:The association between long noncoding RNAs (lncRNAs) and spontaneous regression of neuroblastoma (NB) has rarely been investigated and remains unknown. Objective: To identify prognostic lncRNAs involved in the spontaneous regression of NB. Methods: Differential expression analyses were performed between those samples with an outcome of death in stage 4 NB group and those samples with an outcome of survival in stage 4S NB group in two independent public datasets, respectively.Univariate Cox proportional hazard regression survival analysis was performed in each of the entire cohort to identify those lncRNAs significantly associated with overall survival (OS). Those lncRNAs independently associated with OS were then identified by multivariate Cox survival analysis and used to construct an lncRNA risk score. Results: A total of 20 differentially expressed and survival-related lncRNAs were identified sharing between the two independent cohorts. The expression of each of these 20 lncRNAs was significantly correlated with the expression of NTRK1, which is a wellknown factor involved in NB spontaneous regression. Four lncRNAs (LNC00839, FIRRE, LOC283177, and LOC101928100) were identified to be significantly associated with survival independent with each other and a four-lncRNA signature risk score was constructed. Patients with high lncRNA signature risk score had a significantly poorer OS and event-free survival than those with low lncRNA signature risk score. The four-lncRNA signature has a good performance in predicting survival independent with MYCN amplification (nonamplified vs amplified), age status (<18 months vs ≥18 months), risk status (low risk vs high risk), and International Neuroblastoma Staging System (INSS) stage (INSS 1/2/3/4S vs INSS 4). Conclusions: We identified 20 survival-related lncRNAs that might be associated with the spontaneous regression of NB and developed a four-lncRNA signature risk score. The four-lncRNA signature is an independent prognostic factor for survival of NB patients. | 3801 MENG Et al.

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RETRACTED ARTICLE: Long non-coding RNA TPT1-AS1 promotes cell growth and metastasis in cervical cancer via acting AS a sponge for miR-324-5p

Cited by 72 publications

References 36 publications

LncRNA TPT1‐AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression

LncRNA TPT1‐AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression

<p>Long Non-Coding RNA TMPO-AS1 Promotes Cervical Cancer Cell Proliferation, Migration, and Invasion by Regulating miR-143-3p/ZEB1 Axis</p>

Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma

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