RETRACTED ARTICLE: Membrane-Bound Mucins and Mucin Terminal Glycans Expression in Idiopathic or Helicobacter pylori, NSAID Associated Peptic Ulcers

Niv, Yaron; Boltin, Doron; Halpern, Marisa; Cohen, Miriam; Levi, Zohar; Vilkin, Alex; Morgenstern, Sara; Manugian, Vahig; Lawrence, Erica St.; Gagneux, Pascal; Batra, Surinder K.; Ho, Samuel B.

doi:10.1007/s10620-012-2205-5

Cited by 4 publications

(1 citation statement)

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“…Breach of the gastric mucosa (as in the case of peptic ulcer) is associated with quantitative or ultrastructural changes in the mucin molecule. These changes are mediated by NSAIDs, H. pylori and other factors, and may be pre or post translational in nature [4–6]. …”

Section: Introductionmentioning

confidence: 99%

Mucins in Gastric Cancer - An Update

Boltin¹,

Niv²

2013

J Gastrointest Dig Syst

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Mucins are high-molecular-weight glycoproteins expressed throughout the gastrointestinal tract, with a key role in mucosal protection and function. In gastric cancer expression of MUC5AC and MUC1 is reduced and denovo expression of MUC2 occurs. With progressive loss of tumor differentiation and increased tumor stage, expression of MUC5AC and MUC1 is further reduced, and MUC2 decreases. Isolated MUC2 expression (the intestinal phenotype) correlates with metastatic spread and poor survival. There is emerging evidence that MUC1 acts as an oncoprotein when overexpressed. The cytoplasmic tail of MUC1 interacts with the H. pylori virulence factor cagA and is a major effector of the wnt-β catenin intracellular signalling cascade. Polymorphism in the MUC1 gene has been identified in gastric cancer patients and may have a prospective role in the stratification of high-risk subjects. The MUC1 gene also mediates resistance to the recombinant HER2/neu antibody trastuzumab. Future research efforts will examine targeting MUC1 for therapeutic purposes.

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Section: Introductionmentioning

confidence: 99%