2017
DOI: 10.1186/s12943-017-0615-x
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RETRACTED ARTICLE: MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer

Abstract: BackgroundEven though aberrant expression of microRNA (miR)-30d has been reported in prostate cancer (PCa), its associations with cancer progression remain contradictory. The aim of this study was to investigate clinical significance, biological functions and underlying mechanisms of miR-30d deregulation in PCa.MethodsInvolvement of miR-30d deregulation in malignant phenotypes of PCa was demonstrated by clinical sample evaluation, and in vitro and in vivo experiments. The mechanisms underlying its regulatory e… Show more

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Cited by 80 publications
(88 citation statements)
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“…S3A). VEGFA has been ever reported to be upregulated in many tumor tissues and plays an important role in tumor cell proliferation, migration, invasion and tumor angiogenesis . Therefore, these data suggest that the contribution of LINC01116 knockdown to the inhibition of tumorigenesis, metastasis and angiogenesis in glioma might be through downregulating the expression of VEGFA.…”
Section: Resultsmentioning
confidence: 73%
See 1 more Smart Citation
“…S3A). VEGFA has been ever reported to be upregulated in many tumor tissues and plays an important role in tumor cell proliferation, migration, invasion and tumor angiogenesis . Therefore, these data suggest that the contribution of LINC01116 knockdown to the inhibition of tumorigenesis, metastasis and angiogenesis in glioma might be through downregulating the expression of VEGFA.…”
Section: Resultsmentioning
confidence: 73%
“…VEGFA has been ever reported to be upregulated in many tumor tissues and plays an important role in tumor cell proliferation, migration, invasion and tumor angiogenesis. [35][36][37][38] Therefore, these data suggest that the contribution of LINC01116 knockdown to the inhibition of tumorigenesis, metastasis and angiogenesis in glioma might be through downregulating the expression of VEGFA. Thus, VEGFA may represent an important downstream effector of LINC01116 and potentially mediate this lncRNA effect on tumorigenesis, metastasis and angiogenesis in glioma.…”
Section: Identification Of Linc01116 Target Genesmentioning
confidence: 84%
“…Meanwhile, VEGFA was also found to be markedly upregulated in other tumours. The overexpression of VEGFA is a powerful predictor of overall survival and progression for some cancers, including breast cancer, prostate cancer, lung cancer and glioma [20][21][22][23][24]. Additionally, VEGFA was also demonstrated to increase the motility of PDAC cells [25].…”
Section: Introductionmentioning
confidence: 99%
“…4). The over-expression of miR-30d is thus associated with advanced cancer progression and an unfavorable prognosis [114]. After IR, miR-30d became decreased in PC-3 cells [41] and it was therefore suggested that miR-30d may increase the efficacy of radiotherapy.…”
Section: Mirnas In Tumor Microenvironmentmentioning
confidence: 99%