RETRACTED ARTICLE: Radiofrequency ablation versus hepatic resection for breast cancer liver metastasis: a systematic review and meta-analysis

Abstract

Objective: To evaluate the comparative therapeutic efficacy of radiofrequency ablation (RFA) and hepatic resection (HR) for breast cancer liver metastases (BCLMs). Methods: Studies that had examined the outcomes for both RFA and HR for BCLM were identified by searching the electronic databases PubMed, EMBASE, and the Cochrane Library. Pooled analyzes of the overall survival (OS), disease-free survival (DFS), and short-term outcomes of BCLM were performed. Results: Patients with BCLM gained many more survival benefits from HR than from RFA with regard to the 3-year OS rate (combined odds ratio (OR) 0.41, 95% confidence interval (CI) 0.29-0.59, P<0.001), 5-year OS rate (combined OR 0.38, 95% CI 0.32-0.46, P<0.001), 3-year DFS (combined OR 0.36, 95% CI 0.27-0.49, P<0.001), and 5-year DFS (combined OR 0.51, 95% CI 0.40-0.66, P<0.001). RFA had fewer postoperative complications (combined OR 0.30, 95% CI 0.20-0.44, P<0.001) and shorter hospital stays (combined OR −9.01, 95% CI −13.49-4.54, P<0.001) than HR. Conclusions: HR takes precedence over RFA in the treatment of patients with BCLM, considering the better survival rate. RFA gives rise to fewer complications and can be carried out with a shorter hospital stay, compared to HR. RFA should be reserved for patients who are not optimum candidates for resection.

Clinical practice guidelines for the management of liver metastases from extrahepatic primary cancers 2021

“…For non‐CRLMs, there was a comparative cohort study of patients with liver metastases from gastric cancer and a meta‐analysis of retrospective cohort studies of patients with liver metastases from breast cancer 101,102 . In the gastric cancer study, OS and DFS after HR were statistically significantly better than after ABT 101 .…”

“…101 In the breast cancer study, HR was better than ABT for the 3-year DFS and OS. 102 Currently, there are no comparison studies that show ABT is better than HR for patients with non-CRLM.…”

Oligometastatic Breast Cancer: Is This a Curable Entity? A Contemporary Review of the Literature

“…Head to head trials are lacking, though there is some evidence that the combination appears to be safe and superior to RFA alone [59]. A meta-analysis of 14 studies evaluated the efficacy of RFA compared to hepatic resection and found the latter group to be more efficacious (combined OR for 5 year OS 0.38, p<0.001) [60].…”

Association between social health status and depressive symptoms among community-dwelling elderly adults in Zhejiang Province, China

“…Continuous variables with normal distribution were presented as mean±standard deviation (SD), while non-normally distributed variables were presented as median±interquartile range (IQR) (Xiao et al, 2018). Categorical variables were presented as frequency and proportions.…”