RETRACTED ARTICLE: Systematic pan-cancer analysis identifies transmembrane protein 158 as a potential therapeutic, prognostic and immunological biomarker

Li, Jiayi; Hou, Haiguang; Sun, Jing; Ding, Zhaoxi; Xu, Yingkun; Li, Guibao

doi:10.1007/s10142-023-01032-0

Cited by 5 publications

(4 citation statements)

References 64 publications

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“…The TMEM158 protein, encoded by the gene located on chromosome 3, is also known as RIS1, 40BBP, BBP, and HBBP tumor suppressor ( 71 ). The first reports on TMEM158 showed its function as a receptor for the neurotrophic peptide related to brain injury, which is crucial for the survival of neurons.…”

Section: Tmem Proteins With a Dual Function In Different Types Of Cancermentioning

confidence: 99%

“…Furthermore, there is evidence that TMEM158 may be involved in chemotherapeutic sensitivity and cancer progression by activating signaling pathways such as TGF1 and PI3K/AKT. Therefore, TMEM158 becomes a promising therapeutic target or prognostic biomarker that should continue to be studied until its role is fully understood in the different types of cancer where it has been differentially expressed ( 71 ).…”

Section: Tmem Proteins With a Dual Function In Different Types Of Cancermentioning

confidence: 99%

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The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer

Herrera-Quiterio,

Encarnación-Guevara

2023

Front. Oncol.

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Transmembrane proteins (TMEM) are located in the different biological membranes of the cell and have at least one passage through these cellular compartments. TMEM proteins carry out a wide variety of functions necessary to maintain cell homeostasis TMEM165 participates in glycosylation protein, TMEM88 in the development of cardiomyocytes, TMEM45A in epidermal keratinization, and TMEM74 regulating autophagy. However, for many TMEM proteins, their physiological function remains unknown. The role of these proteins is being recently investigated in cancer since transcriptomic and proteomic studies have revealed that exits differential expression of TMEM proteins in different neoplasms concerning cancer-free tissues. Among the cellular processes in which TMEM proteins have been involved in cancer are the promotion or suppression of cell proliferation, epithelial-mesenchymal transition, invasion, migration, intravasation/extravasation, metastasis, modulation of the immune response, and response to antineoplastic drugs. Inclusive data suggests that the participation of TMEM proteins in these cellular events could be carried out through involvement in different cell signaling pathways. However, the exact mechanisms not clear. This review shows a description of the involvement of TMEM proteins that promote or decrease cell proliferation, migration, and invasion in cancer cells, describes those TMEM proteins for which both a tumor suppressor and a tumor promoter role have been identified, depending on the type of cancer in which the protein is expressed. As well as some TMEM proteins involved in chemoresistance. A better characterization of these proteins is required to improve the understanding of the tumors in which their expression and function are altered; in addition to improving the understanding of the role of these proteins in cancer will show those TMEM proteins be potential candidates as biomarkers of response to chemotherapy or prognostic biomarkers or as potential therapeutic targets in cancer.

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Section: Tmem Proteins With a Dual Function In Different Types Of Cancermentioning

confidence: 99%

Section: Tmem Proteins With a Dual Function In Different Types Of Cancermentioning

confidence: 99%

The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer

Herrera-Quiterio,

Encarnación-Guevara

2023

Front. Oncol.

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“…No significant associations were found between the expression of this cluster of genes and patients' survival (p>0.05). Although all these genes have been previously described in cancer [356][357][358][359][360][361], not all of them have been studied for their presence in NSCLC tumor cells, so their true role in this disease is still unknown. In addition, only XAGE1 and TTF-1 have been related to a specific histologic subtype.…”

Section: In-silico Validation Of Exosomal Biomarkers In Nsclcmentioning

confidence: 99%

“…Additionally, plasma exosomal RIOK3 expression was significantly associated with EGFR, KRAS, ALK or PD-L1 positive tumours, as opposed to those with undetectable mutations. Previous evidence has shown that higher RIOK3 expression in tumours, compared to healthy tissue, may be associated with the level of mismatch repair (MMR) gene mutations and DNA methyltransferase expression [360]. However, further analysis in a larger group of patients would be needed to determine whether there is a reliable association between RIOK3 expression and the presence of molecular alterations.…”

Section: Analysis Of Plasma Exo-mrna For Biomarkers Detectionmentioning

confidence: 99%

Liquid Biopsy in non-small cell lung cancer: exosomes as a tool for the study of biomarkers.

Duréndez Sáez

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Despite recent advancements in lung cancer treatment, its incidence and mortality rates remain high worldwide. Specifically, non-small cell lung cancer (NSCLC) accounts for nearly 85% of all lung cancers, with a 5-year survival rate of 20%. Given this scenario, the primary objective of this study is to comprehensively characterize the exosomes secreted by NSCLC cells. These microvesicles are known to be involved in numerous tumoral processes, potentially containing a wealth of information about the molecular characteristics of the disease.To achieve this, primary cultures and cell lines, along with peripheral blood samples obtained from NSCLC patients were used. An initial screening in exosomes secreted in vitro allowed the identification of a significant number of mRNAs and miRNAs, related to various biological processes and signaling pathways. Moreover, some genes such as FDFT1 and SNAI1 stood out due to their overexpression in exosomes derived from cells grown in tumorspheres formation (3D models), which are enriched in cancer stem cell population. Additionally, markers found within these microvesicles were associated with two of the most common histological subtypes: adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC).Subsequently, to validate the findings seen in exosomes, the most significant markers were analyzed in silico in an NSCLC tissue cohort from the TCGA database. These results revealed an association between the expression of SNAI1 and patient survival (OS and RFS, p<0.05). Furthermore, XAGE1B, SEPP1, and TTF-1 expression (previously identified in exosomes) maintained a significant relationship with the LUAD group, while CABYR, RIOK3, and CAPRIN1 remained overexpressed in LUSC patients (Mann-Whitney test, p<0.05). These markers were also analyzed in a cohort of 186 NSCLC patients from the University General Hospital of Valencia. The association of SNAI1 expression and the survival of early-stage patients (RFS in LUAD patients, p<0.05) was confirmed, as well as the overexpression of CABYR and RIOK3 in LUSC patients, and of XAGE1B and TTF-1 in LUAD.

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Pan-cancer evidence of prognosis, immune infiltration, and immunotherapy efficacy for annexin family using multi-omics data

Zhang

2023

Funct Integr Genomics

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RETRACTED ARTICLE: Systematic pan-cancer analysis identifies transmembrane protein 158 as a potential therapeutic, prognostic and immunological biomarker

Cited by 5 publications

References 64 publications

The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer

The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer

Liquid Biopsy in non-small cell lung cancer: exosomes as a tool for the study of biomarkers.

Pan-cancer evidence of prognosis, immune infiltration, and immunotherapy efficacy for annexin family using multi-omics data

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