RETRACTED ARTICLE: Two new polyoxometalate-based transition metal complexes inhibit bladder cancer cell growth <i>via</i> mitochondrial apoptotic pathway

Xiao, Huiyuan; Wu, Baojun; Chen, Xue; Wang, Fan

doi:10.1080/00958972.2019.1599871

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…In the last decade, there have been so many reports that show the high IC 50 values and long time of treatment for POM cytotoxicity evaluation. On the other hand, it seems that the anticancer activity of POMs is related to the type and content of the metal in the cell and available intracellular pathways . To understand if the high IC 50 values and late effects are related to intracellular pathways or problems in uptake by cells, we should measure the cellular content of POMs .…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, it seems that the anticancer activity of POMs is related to the type and content of the metal in the cell and available intracellular pathways. 82 To understand if the high IC 50 values and late effects are related to intracellular pathways or problems in uptake by cells, we should measure the cellular content of POMs. 83 In this study, the cellular uptake was measured using two different methods.…”

Section: Synthesis Of [Tba]mentioning

confidence: 99%

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Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and In Vitro Cytotoxicity Evaluations

et al. 2021

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This study is aimed at developing a micellar carrier for an Anderson-type manganese polyoxomolybdate (TRIS-MnPOMo) to improve the potency and reduce the general toxicity. The biotin-targeted stearic acid–polyethylene glycol (SPB) polymeric conjugate was selected for the first time as a micelle-forming basis for the delivery of TRIS-MnPOMo to breast cancer cells. The cytotoxicity of TRIS-MnPOMo and its nanomicellar form (TRIS-MnPOMo@SPB) was evaluated against MCF-7, MDA-MB-231 (breast cancer cell lines), and HUVEC (normal cell line) in vitro using the MTT assay. The quantity of cellular uptake and apoptosis level were studied properly using standard methods. The hydrodynamic size, zeta potential, and polydispersity index of the prepared micelles were 140 nm, −15.6 mV, and 0.16, respectively. The critical micelle concentration was about 30 μg/mL, which supports the colloidal stability of the micellar dispersion. The entrapment efficiency was interestingly high (about 82%), and a pH-responsive release of TRIS-MnPOMo was successfully achieved. The micellar form showed better cytotoxicity than the free TRIS-MnPOMo on cancer cells without any significant heme and normal cell toxicity. Biotin-targeted nanomicelles internalized into the MDA-MB-231 cells interestingly better than nontargeted micelles and TRIS-MnPOMo, most probably via the endocytosis pathway. Furthermore, at the same concentration, micelles remarkably increased the level of induced apoptosis in MDA-MB-231 cells. In conclusion, TRIS-MnPOMo@SPB could profoundly improve potency, safety, and cellular uptake; these results are promising for further evaluations in vivo.

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Section: Resultsmentioning

confidence: 99%

Section: Synthesis Of [Tba]mentioning

confidence: 99%

Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and In Vitro Cytotoxicity Evaluations

et al. 2021

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“…Nanoparticulate delivery systems should be up taken by target cells before any biological activity onset. In the case of POMs, it always has been questioned if the high IC50s is related to cellular uptake or any intracellular mechanism (69,70).…”

Section: Analysis Of Cellular Uptakementioning

confidence: 99%

Hybrid Nanocomposite of Imidazolium Based Chitosan and Anderson-type Manganese Polyoxomolybdate for Boosting Drug Delivery Against Breast Cancer

Mahvash

Zavareh²,

Taymouri

et al. 2021

Preprint

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Polyoxometalates (POMs) are a class of inorganic cytotoxic agents with potential anticancer effects. As the nano-formulation is one of the best approaches to adjust the therapeutic effects along with selective delivery, in this study, a novel biocompatible nano-composite (NC) of Anderson-type manganese polyoxomolybdate (MnMo6) was prepared using chitosan conjugate to achieve better selective cytotoxicity profile.Imidazolium modified chitosan (CSIm) was utilizedto getthe MnMo6 hybridNCs (MnMo6@CSIm NCs).The best resulting NCs were evaluated for their anticancer activity against breast cancer cell lines (MCF-7 & MDA-MB-231) as well as HUVEC normal cells using MTT assay. Furthermore, cellular uptake, apoptosis ratio and cell migration inhibition were evaluated on the MDA-MB-231 cell line as the triple-negative aggressive cell line.The optimized NPs had a zeta potential above +27 mV with a uniform distribution of sizes around 145 nm. The loading content and release efficiency were both satisfying (about 44% and 98%). In the release study, a pH-responsive release was detectedcomparing the neutral conditions.The NCs had a better anticancer activity than free MnMo6 in both cancer cell lines, without detectable cytotoxicity against HUVEC normal cells. The cellular uptake was about 100 %, and apoptosis value was enough high (81%) compared to free MnMo6. Interestingly, the MnMo6 hybrid NCs inhibitedthe cell migration of MDA-MB-231 cell line1.5 times better than the free MnMo6. All of these results are fascinating to follow more pre-clinical studies on this hybrid NC.

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Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects against Triple-negative Breast Cancer Cells

Mohajer,

Varshosaz,

Jahanian-Najafabadi

et al. 2024

J Inorg Organomet Polym

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RETRACTED ARTICLE: Two new polyoxometalate-based transition metal complexes inhibit bladder cancer cell growth via mitochondrial apoptotic pathway

Cited by 5 publications

References 4 publications

Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and In Vitro Cytotoxicity Evaluations

Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and In Vitro Cytotoxicity Evaluations

Hybrid Nanocomposite of Imidazolium Based Chitosan and Anderson-type Manganese Polyoxomolybdate for Boosting Drug Delivery Against Breast Cancer

Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects against Triple-negative Breast Cancer Cells

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