RETRACTED ARTICLE: Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma

Li, Toshio; Xie, Junjie; Shen, Chuan; Cheng, Dongfeng; Shi, Yuan; Wu, Zhichong; Deng, Xiaxing; Chen, H; Shen, Baiyong; Peng, Chenghong; Li, H; Zhan, Qimin; Zhu, Zhenggang

doi:10.1038/onc.2015.223

Cited by 257 publications

(246 citation statements)

References 43 publications

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“…However, an increased level of ZEB2 in the cytosol was revealed to downregulate E-cadherin, and enable cells to undergo EMT (31). Similarly, ZEB1-AS1 upregulation has been reported to increase the promoter activity of the ZEB1 gene resulting in the repression of E-cadherin, and induction of EMT in hepatocellular carcinoma (22). The results of the present study identified a co-expression pattern in ZEB2 and ZEB2-AS1 in oral tumor samples.…”

Section: Discussionsupporting

confidence: 48%

“…The ZEB transcription factors may downregulate the expression of miR-200 family miRNAs. In addition, natural anti-sense transcript ZEB1-AS1 was demonstrated to enhance the transcription of ZEB1 and increase mRNA stability within the cytosol (30,22). Similarly, ZEB2 stability may also be enhanced by ZEB2-AS1 expression.…”

Section: Discussionmentioning

confidence: 99%

“…ZEB1-AS1, a natural antisense transcript has previously been reported to upregulate the expression of ZEB1 in tumor cells (22). The present study investigated the association between the expression of ZEB1 and its antisense transcript ZEB1-AS1 in head and neck datasets obtained from TCGA and identified that majority of the tumor samples co-expressed ZEB1 and ZEB1-AS1 (data not shown).…”

Section: Expression Of Emt Activators Their Antisense Transcripts Anmentioning

confidence: 97%

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Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma

et al. 2017

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were significantly upregulated in the oral tumors. Furthermore, ZEB2 antisense RNA1 was overexpressed in 50% of OSCC samples (P= 0.0075). EMT-regulatory genes did not exhibit any association with clinical outcome. The present study also analyzed the expression of EMT-regulatory genes in 523 head and neck squamous cell carcinoma (HNSCC) samples from The Cancer Genome Atlas (TCGA) database, and the association with treatment outcome. Analysis of TCGA datasets also demonstrated no significant association in the expression of EMT markers with disease recurrence and treatment outcome. The results of the present study revealed dysregulation of miR-200 family miRNAs and EMT-regulatory genes in OSCC without any significant effect on treatment outcome.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Expression Of Emt Activators Their Antisense Transcripts Anmentioning

confidence: 97%

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Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma

et al. 2017

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“…ZEB2-AS1 is a recently identified lncRNA that has been demonstrated to perform significant functions in HCC (14,15). It is a non-coding antisense transcript from the promoters of ZEB2, which is reported to function as a transcription factor and is associated with a number of distinct types of cancer (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

“…Zinc finger E-box-binding homeobox 2 antisense RNA 1 (ZEB2-AS1) is a non-coding oncogene identified in human hepatocellular carcinoma (HCC) (14). Li et al (15) demonstrated that the relative transcript level of ZEB2-AS1 was upregulated in HCC in vivo and in vitro and functioned as a prognostic factor for HCC pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA ZEB2-AS1 promotes proliferation and inhibits apoptosis in human lung cancer cells

Guo

et al. 2018

Oncol Lett

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Abstract. Lung cancer is among the leading causes of cancer-associated mortality worldwide, with a low 5-year survival rate of 16.1%. However, the underlying molecular mechanisms behind lung cancer tumorigenesis remain largely unknown. Long non-coding RNAs (lncRNAs) have been demonstrated to serve a function in the tumorigenesis of multiple types of cancer. The objective of the present study was to identify the function of a newly identified lncRNA zinc finger E-box-binding homeobox 2 antisense RNA 1 (ZEB2-AS1) in human lung cancer. Results demonstrated that the transcript level of ZEB2-AS1 in human lung cancer was markedly upregulated in vivo and in vitro. The knockdown of ZEB2-AS1 in A549 and NCI-H292 cells, and the overexpression of ZEB2-AS1 in H-125 and H1975 cells, altered colony formation and cell proliferative rate, as examined using colony formation and cell proliferation assays. Western blot analysis revealed that the knockdown of ZEB2-AS1 in A549 and NCI-H292 cells increased the protein levels of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), caspase-3 and -9, upregulated the relative activities of caspase-3 and -9, and had no observable effect on caspase-8 activity. Similarly, the overexpression of ZEB2-AS1 in H-125 and H1975 cells resulted in decreased expression of caspase-3, caspase-9, Bcl-2 and Bax. The results identified the effects of lncRNA ZEB2-AS1 on lung cancer progression through promoting its proliferation and inhibiting cell apoptosis, indicating that ZEB2-AS1 may serve as a novel prognostic factor for the diagnosis and treatment of human lung cancer in the clinic.

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Single‐cell RNA‐seq reveals the invasive trajectory and molecular cascades underlying glioblastoma progression

Pang

et al. 2019

Molecular Oncology

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Glioblastoma (GBM) is the most common and aggressive primary brain tumor, in which GBM stem cells (GSCs) were identified to contribute to aggressive phenotypes and poor prognosis. Yet, how GSCs progress to invasive cells remains largely unexplored. Here, we revealed the cell subpopulations with distinct functional status and the existence of cells with high invasive potential within heterogeneous primary GBM tumors. We reconstructed a branched trajectory by pseudotemporal ordering of single tumor cells, in which the root showed GSC‐like phenotype while the end displayed high invasive activity. Thus, we further determined a path along which GSCs gradually transformed to invasive cells, called the ‘stem‐to‐invasion path’. Along this path, cells showed incremental expression of GBM invasion‐associated signatures and diminishing expression of GBM stem cell markers. These findings were validated in an independent single‐cell data set of GBM. Through analyzing the molecular cascades underlying the path, we identify crucial factors controlling the attainment of invasive potential of tumor cells, including transcription factors and long noncoding RNAs. Our work provides novel insights into GBM progression, especially the attainment of invasive potential in primary tumor cells, and supports the cancer stem cell model, with valuable implications for GBM therapy.

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RETRACTED ARTICLE: Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma

Cited by 257 publications

References 43 publications

Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma

Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma

Long non-coding RNA ZEB2-AS1 promotes proliferation and inhibits apoptosis in human lung cancer cells

Single‐cell RNA‐seq reveals the invasive trajectory and molecular cascades underlying glioblastoma progression

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